PMID- 33212266
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 1873-1597 (Electronic)
IS  - 1572-1000 (Linking)
VI  - 33
DP  - 2021 Mar
TI  - Evaluation of antimicrobial photodynamic therapy on wounds infected by 
      Staphylococcus aureus in animal models.
PG  - 102092
LID - S1572-1000(20)30446-4 [pii]
LID - 10.1016/j.pdpdt.2020.102092 [doi]
AB  - BACKGROUND: Antibiotic-resistant Staphylococcus aureus bacteria are one of the 
      expanding challenges. The purpose of current study is to evaluate the 
      antimicrobial effect of photodynamic therapy (aPDT) on wounds infected to 
      Staphylococcus aureus. METHODS: In this study, 40 six-month-old rats were divided 
      into 4 groups: control, photosensitizer (PS), laser, and aPDT. A full-thickness 
      wound was created on their skin and it was infected by Staphylococcus aureus. For 
      aPDT, the Indocyanine Green (Germany, Nurnberg, A.R.C. Laser, EmunDo) 
      photosensitive agent and laser diod 810 nm (Germany, Nurnberg, A.R.C. Laser) was 
      utilized. The wound healing procedure was monitored every 24 h until the 12th day 
      with photography. The number of the bacteria was counted on the 12th day also. 
      All results were compared using ANOVA and Tukey post hoc tests. Significance 
      level was considered P-Value < 0.05. RESULTS: The average area of wound reduced 
      in days 5-11th in photosensitizer, laser, and aPDT, respectively. The absolute 
      colonization rate of bacteria in the wounds showed a significant decrease in two 
      groups laser and aPDT compared to the control group. However, the lowest value 
      was for the aPDT. CONCLUSION: In the conditions of this study, it emerged that 
      aPDT and laser have an antimicrobial effect against antibiotic-resistant bacteria 
      (particularly Staphylococcus aureus) and improve wound healing.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Torabi, Sepehr
AU  - Torabi S
AD  - Periodontology Department, Dental Faculty, AJA University of Medical Sciences, 
      Tehran, Iran. Electronic address: sphr.torabi@gmail.com.
FAU - Joharchi, Khojasteh
AU  - Joharchi K
AD  - Department of Pharmacology, School of Medicine, Shahid Beheshti University of 
      Medical Sciences, Tehran, Iran. Electronic address: Joharchi-kh@sbmu.ac.ir.
FAU - Kalhori, Katayoun A M
AU  - Kalhori KAM
AD  - Oral & Maxillofacial Pathologist. Iranian Medical Laser Association, Tehran, 
      Iran. Electronic address: kathykalhor@yahoo.com.
FAU - Sohrabi, Mona
AU  - Sohrabi M
AD  - Pediatric Dentistry Department, School of Dentistry, Arak University of Medical 
      Sciences, Arak, Iran. Electronic address: Monasohrabi@yahoo.com.
FAU - Fekrazad, Reza
AU  - Fekrazad R
AD  - Radiation Sciences Research Center, Laser Research Center in Medical Sciences, 
      AJA University of Medical Sciences, Tehran, Iran; International Network for Photo 
      Medicine and Photo Dynamic Therapy (INPMPDT), Universal Scientific Education and 
      Research(USERN), Tehran, Iran. Electronic address: rezafekraza@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20201116
PL  - Netherlands
TA  - Photodiagnosis Photodyn Ther
JT  - Photodiagnosis and photodynamic therapy
JID - 101226123
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Anti-Infective Agents)
RN  - 0 (Photosensitizing Agents)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents/pharmacology
MH  - *Anti-Infective Agents
MH  - *Methicillin-Resistant Staphylococcus aureus
MH  - Models, Animal
MH  - *Photochemotherapy/methods
MH  - Photosensitizing Agents/pharmacology
MH  - Rats
MH  - Staphylococcus aureus
OTO - NOTNLM
OT  - Antibiotics
OT  - Antimicrobial photodynamic therapy
OT  - Laser
OT  - Photosensitizer
OT  - Staphylococcus aureus
EDAT- 2020/11/20 06:00
MHDA- 2021/05/15 06:00
CRDT- 2020/11/19 20:09
PHST- 2020/05/12 00:00 [received]
PHST- 2020/10/29 00:00 [revised]
PHST- 2020/10/30 00:00 [accepted]
PHST- 2020/11/20 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2020/11/19 20:09 [entrez]
AID - S1572-1000(20)30446-4 [pii]
AID - 10.1016/j.pdpdt.2020.102092 [doi]
PST - ppublish
SO  - Photodiagnosis Photodyn Ther. 2021 Mar;33:102092. doi: 
      10.1016/j.pdpdt.2020.102092. Epub 2020 Nov 16.