PMID- 33212306
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210110
IS  - 2210-2612 (Print)
IS  - 2210-2612 (Electronic)
IS  - 2210-2612 (Linking)
VI  - 77
DP  - 2020
TI  - Less than subtotal parathyroidectomy in multiple endocrine neoplasia type 1: A 
      case report and review of the literature.
PG  - 337-340
LID - S2210-2612(20)31030-0 [pii]
LID - 10.1016/j.ijscr.2020.10.140 [doi]
AB  - INTRODUCTION: Multiple endocrine neoplasia type 1 (MEN1) is a rare syndrome with 
      common presenting signs and symptoms secondary to primary hyperparathyroidism 
      (PHPT), which is managed surgically. Traditionally, either subtotal 
      parathyroidectomy (SPTX) or total parathyroidectomy with autologous 
      transplantation (TPTX) is the approach of choice. However, recent studies showed 
      comparable persistence and recurrence rate in a subset of MEN1 patients (two or 
      more concordant preoperative imaging results) who underwent less than subtotal 
      parathyroidectomy (LSPTX). PRESENTATION OF CASE: We report a case of patient with 
      PHPT and delayed diagnosis of MEN1, who underwent LSPTX without intraoperative 
      parathyroid hormone (IOPTH) measurement. The approach was chosen based on the 
      preoperative imaging studies. Unfortunately, the PHPT persisted and the patient 
      was reoperated. To further elucidate the issue, a systematic search of the 
      literature was conducted on Cochrane library, PubMed, and Scopus; articles 
      relevant to the case were reviewed. Results are conflicting results with most of 
      the studies showed LSPTX is inferior compared to the other two approaches. 
      DISCUSSION: Therefore, given the current body of evidence, we consider that 
      subtotal or total parathyroidectomy is still the preferred surgical approach for 
      the treatment of PHPT in MEN1. CONCLUSION: Further studies are still needed to 
      see whether LSPTX is comparable to SPTX or TPTX in regards to persistent and 
      recurrent hyperparathyroidism if the conditions are met.
CI  - Copyright (c) 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Kartini, Diani
AU  - Kartini D
AD  - Department of Surgery, Surgical Oncology Subdivision, Dr. Cipto Mangunkusumo 
      General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, 
      Indonesia. Electronic address: d.kartini@gmail.com.
FAU - Dasawala, Filipus
AU  - Dasawala F
AD  - Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, 
      10430, Indonesia. Electronic address: fdasawala@gmail.com.
FAU - Ham, Maria Francisca
AU  - Ham MF
AD  - Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, 
      Jakarta, 10430, Indonesia. Electronic address: mariafranciscaham@gmail.com.
LA  - eng
PT  - Case Reports
DEP - 20201110
PL  - Netherlands
TA  - Int J Surg Case Rep
JT  - International journal of surgery case reports
JID - 101529872
PMC - PMC7683229
OTO - NOTNLM
OT  - Case report
OT  - Multiple endocrine neoplasia type 1 (MEN1)
OT  - Parathyroidectomy
OT  - Primary hyperparathyroidism (PHPT)
EDAT- 2020/11/20 06:00
MHDA- 2020/11/20 06:01
PMCR- 2020/11/10
CRDT- 2020/11/19 20:09
PHST- 2020/10/29 00:00 [received]
PHST- 2020/10/31 00:00 [accepted]
PHST- 2020/11/20 06:00 [pubmed]
PHST- 2020/11/20 06:01 [medline]
PHST- 2020/11/19 20:09 [entrez]
PHST- 2020/11/10 00:00 [pmc-release]
AID - S2210-2612(20)31030-0 [pii]
AID - 10.1016/j.ijscr.2020.10.140 [doi]
PST - ppublish
SO  - Int J Surg Case Rep. 2020;77:337-340. doi: 10.1016/j.ijscr.2020.10.140. Epub 2020 
      Nov 10.