PMID- 33219160
OWN - NLM
STAT- MEDLINE
DCOM- 20211125
LR  - 20211125
IS  - 1535-5675 (Electronic)
IS  - 0091-4916 (Linking)
VI  - 49
IP  - 1
DP  - 2021 Mar
TI  - Use of Advanced CT Technology to Evaluate Left Atrial Indices in Patients with a 
      High Heart Rate or with Heart Rate Variability: The Converge Registry.
PG  - 65-69
LID - 10.2967/jnmt.120.253781 [doi]
AB  - We intended to assess the ability of current-generation 256-slice coronary CT 
      angiography (CCTA) to measure left atrial volume (LAV), comparing patients with a 
      high heart rate (HiHR) of at least 70 bpm and patients with heart rate 
      variability such as atrial fibrillation (AFib). Methods: Using the prospective 
      Converge Registry of patients undergoing 256-detector CCTA on a Revolution 
      scanner, we enrolled 121 HiHR patients (74 men; mean age, 62.7 +/- 12.5 y) and 102 
      AFib patients (72 men; mean age, 60.5 +/- 11.0 y) after obtaining informed consent. 
      Quantitative data analysis of LAV was performed using automated methods, and 
      end-systolic phases were chosen for measurements from CCTA. A Student t test, 
      Wilcoxon rank-sum test, or chi(2) test assessed baseline parameters. Univariate and 
      multivariate linear regression analysis was used to assess LAV and LAV index 
      (LAVI) while adjusting potentially confounding variables. Results: Mean LAV was 
      significantly higher in AFib subjects (148.6 +/- 57.2 mL) than in HiHR subjects 
      (102.1 +/- 36.5 mL) (P < 0.0001). Similarly, mean LAVI was significantly higher in 
      AFib subjects (72.4 +/- 28.1 mL/m(2)) than in HiHR subjects (51.5 +/- 19.0 mL/m(2)) 
      (P < 0.0001). After adjusting for age, body mass index, sex, diabetes, 
      hypertension, hyperlipidemia, and smoking, subjects with AFib had, on average, 
      LAV measures higher by 41.2 +/- 6.7 mL and LAVI values higher by 23.1 +/- 3.4 mL/m(2) 
      (P < 0.0001). Conclusion: Misalignment and motion artifacts in CCTA images affect 
      diagnostic CT performance, especially in patients with elevated heart rates or 
      profound arrhythmia. However, the new-generation Revolution CCTA provides 
      detailed information on left-atrium-complex morphology and function, in addition 
      to coronary anatomy, in HiHR and AFib patients without additional radiation, 
      scanning, or contrast requirements.
CI  - (c) 2021 by the Society of Nuclear Medicine and Molecular Imaging.
FAU - Cherukuri, Lavanya
AU  - Cherukuri L
AD  - Lundquist Institute for Biomedical Innovation, Harbor UCLA Medical Center, 
      Torrance, California.
FAU - Birudaraju, Divya
AU  - Birudaraju D
AD  - Lundquist Institute for Biomedical Innovation, Harbor UCLA Medical Center, 
      Torrance, California.
FAU - Kinninger, April
AU  - Kinninger A
AD  - Lundquist Institute for Biomedical Innovation, Harbor UCLA Medical Center, 
      Torrance, California.
FAU - Chaganti, Bhanu T
AU  - Chaganti BT
AD  - Texas Tech University Health Sciences Center, El Paso, Texas.
FAU - Pidikiti, Sivakrishna
AU  - Pidikiti S
AD  - Lundquist Institute for Biomedical Innovation, Harbor UCLA Medical Center, 
      Torrance, California.
FAU - Pozon, Ryan G
AU  - Pozon RG
AD  - Lundquist Institute for Biomedical Innovation, Harbor UCLA Medical Center, 
      Torrance, California.
FAU - Pozon, Anne Concepcion G
AU  - Pozon ACG
AD  - Lundquist Institute for Biomedical Innovation, Harbor UCLA Medical Center, 
      Torrance, California.
FAU - Lakshmanan, Suvasini
AU  - Lakshmanan S
AD  - Lundquist Institute for Biomedical Innovation, Harbor UCLA Medical Center, 
      Torrance, California.
FAU - Dahal, Suraj
AU  - Dahal S
AD  - Lundquist Institute for Biomedical Innovation, Harbor UCLA Medical Center, 
      Torrance, California.
FAU - Hamal, Sajad
AU  - Hamal S
AD  - Lundquist Institute for Biomedical Innovation, Harbor UCLA Medical Center, 
      Torrance, California.
FAU - Flores, Ferdinand
AU  - Flores F
AD  - Lundquist Institute for Biomedical Innovation, Harbor UCLA Medical Center, 
      Torrance, California.
FAU - Christopher, Dialing
AU  - Christopher D
AD  - Lundquist Institute for Biomedical Innovation, Harbor UCLA Medical Center, 
      Torrance, California.
FAU - Andreini, Daniele
AU  - Andreini D
AD  - Centro Cardiologico Monzino, IRCCS, Milan, Italy.
AD  - Department of Clinical Sciences and Community Health, Cardiovascular Section, 
      University of Milan, Milan, Italy.
FAU - Pontone, Gianluca
AU  - Pontone G
AD  - Centro Cardiologico Monzino, IRCCS, Milan, Italy.
FAU - Conte, Edoardo
AU  - Conte E
AD  - Centro Cardiologico Monzino, IRCCS, Milan, Italy.
FAU - Nakanishi, Rine
AU  - Nakanishi R
AD  - Department of Cardiovascular Medicine, Toho University Graduate School of 
      Medicine, Tokyo, Japan.
FAU - O'Rourke, Rachael
AU  - O'Rourke R
AD  - Department of Medical Imaging, Prince Charles Hospital, Brisbane, Queensland, 
      Australia; and.
FAU - Hamilton-Craig, Christian
AU  - Hamilton-Craig C
AD  - Department of Medical Imaging, Prince Charles Hospital, Brisbane, Queensland, 
      Australia; and.
FAU - Nasir, Khurram
AU  - Nasir K
AD  - Baptist Heart Medical Group, Miami, Florida.
FAU - Roy, Sion K
AU  - Roy SK
AD  - Lundquist Institute for Biomedical Innovation, Harbor UCLA Medical Center, 
      Torrance, California.
FAU - Mao, Song Shou
AU  - Mao SS
AD  - Lundquist Institute for Biomedical Innovation, Harbor UCLA Medical Center, 
      Torrance, California.
FAU - Budoff, Matthew J
AU  - Budoff MJ
AD  - Lundquist Institute for Biomedical Innovation, Harbor UCLA Medical Center, 
      Torrance, California mbudoff@labiomed.org.
LA  - eng
PT  - Journal Article
DEP - 20201120
PL  - United States
TA  - J Nucl Med Technol
JT  - Journal of nuclear medicine technology
JID - 0430303
SB  - IM
MH  - Aged
MH  - *Computed Tomography Angiography
MH  - *Heart Atria/diagnostic imaging
MH  - Heart Rate
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Registries
MH  - Technology
OTO - NOTNLM
OT  - arrhythmia
OT  - heart rate variability
OT  - high heart rate
OT  - left atrial volume
OT  - motion artifacts
EDAT- 2020/11/22 06:00
MHDA- 2021/11/26 06:00
CRDT- 2020/11/21 05:31
PHST- 2020/07/16 00:00 [received]
PHST- 2020/09/09 00:00 [accepted]
PHST- 2020/11/22 06:00 [pubmed]
PHST- 2021/11/26 06:00 [medline]
PHST- 2020/11/21 05:31 [entrez]
AID - jnmt.120.253781 [pii]
AID - 10.2967/jnmt.120.253781 [doi]
PST - ppublish
SO  - J Nucl Med Technol. 2021 Mar;49(1):65-69. doi: 10.2967/jnmt.120.253781. Epub 2020 
      Nov 20.