PMID- 33219243
OWN - NLM
STAT- MEDLINE
DCOM- 20210330
LR  - 20210330
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 10
IP  - 1
DP  - 2020 Nov 20
TI  - Preclinical studies of non-stick thin film metallic glass-coated syringe needles.
PG  - 20313
LID - 10.1038/s41598-020-77008-y [doi]
LID - 20313
AB  - Our objective in this study was to determine the biocompatibility and 
      hemocompatibility of thin film metallic glass (TFMG) and its potential use in 
      hypodermic needles for intramuscular or intravenous injection. Mouse and rabbit 
      models were employed under approval from the Institutional Animal Care and Use 
      Committee (n = 5/group, two groups in total for both animal models). 
      Platelet-rich plasma (PRP) was collected from the whole blood of rabbits (ear 
      vein) without anti-coagulant for use in in vitro coagulation tests. Histological 
      analysis and optical microscopy were used to assess the endothelial structure of 
      the inner lining of veins after being punctured with needles and detained for 
      3 days. Histological analysis of ear vein sections revealed that the extent of 
      endothelial damage after puncturing with a TFMG-coated needle was 33% less than 
      that produced by bare needles. Our results confirm that the deposition of a thin 
      TFMG layer (e.g., Zr(53)Cu(33)Al(9)Ta(5)) on the surface of hypodermic needle can 
      have remarkably clinical benefits, including anti-adhesion, reduced invasion, and 
      minimal endothelial damage. Our results also confirm the good biocompatibility 
      and hemocompatibility of the TFMG coatings.
FAU - Bai, Meng-Yi
AU  - Bai MY
AD  - Graduate Institute of Biomedical Engineering, National Taiwan University of 
      Science and Technology, No. 43, Keelung Rd., Sec.4, Da'an Dist., Taipei City, 
      10607, Taiwan. mybai@mail.ntust.edu.tw.
AD  - Adjunct Appointment to the National Defense Medical Center, Taipei City, 11490, 
      Taiwan. mybai@mail.ntust.edu.tw.
FAU - Chang, Ya-Chu
AU  - Chang YC
AD  - Department of Materials Science and Engineering, National Taiwan University of 
      Science and Technology, No. 43, Keelung Rd., Sec.4, Da'an Dist., Taipei City, 
      10607, Taiwan.
FAU - Chu, Jinn P
AU  - Chu JP
AD  - Department of Materials Science and Engineering, National Taiwan University of 
      Science and Technology, No. 43, Keelung Rd., Sec.4, Da'an Dist., Taipei City, 
      10607, Taiwan. jpchu@mail.ntust.edu.tw.
AD  - Applied Research Center for Thin-Film Metallic Glass, National Taiwan University 
      of Science and Technology, Taipei City, 10607, Taiwan. jpchu@mail.ntust.edu.tw.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201120
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Coated Materials, Biocompatible)
SB  - IM
MH  - 3T3 Cells
MH  - Animals
MH  - Blood Coagulation/drug effects
MH  - Cell Adhesion/drug effects
MH  - Coated Materials, Biocompatible/*adverse effects/chemistry
MH  - Endothelium, Vascular/drug effects
MH  - Equipment Design
MH  - Glass/chemistry
MH  - Injections, Intramuscular/instrumentation
MH  - Injections, Intravenous/instrumentation
MH  - Male
MH  - *Materials Testing
MH  - Metal Nanoparticles/*adverse effects/chemistry
MH  - Mice
MH  - Models, Animal
MH  - Needles/*adverse effects
MH  - Platelet-Rich Plasma/drug effects
MH  - Rabbits
MH  - Surface Properties
PMC - PMC7679377
COIS- The authors declare no competing interests.
EDAT- 2020/11/22 06:00
MHDA- 2021/03/31 06:00
PMCR- 2020/11/20
CRDT- 2020/11/21 05:33
PHST- 2020/04/24 00:00 [received]
PHST- 2020/10/16 00:00 [accepted]
PHST- 2020/11/21 05:33 [entrez]
PHST- 2020/11/22 06:00 [pubmed]
PHST- 2021/03/31 06:00 [medline]
PHST- 2020/11/20 00:00 [pmc-release]
AID - 10.1038/s41598-020-77008-y [pii]
AID - 77008 [pii]
AID - 10.1038/s41598-020-77008-y [doi]
PST - epublish
SO  - Sci Rep. 2020 Nov 20;10(1):20313. doi: 10.1038/s41598-020-77008-y.