PMID- 33219649
OWN - NLM
STAT- MEDLINE
DCOM- 20210526
LR  - 20210526
IS  - 1080-6059 (Electronic)
IS  - 1080-6040 (Print)
IS  - 1080-6040 (Linking)
VI  - 26
IP  - 12
DP  - 2020 Dec
TI  - Human-Pathogenic Kasokero Virus in Field-Collected Ticks.
PG  - 2944-2950
LID - 10.3201/eid2612.202411 [doi]
AB  - Kasokero virus (KASV; genus Orthonairovirus) was first isolated in 1977 at Uganda 
      Virus Research Institute from serum collected from Rousettus aegyptiacus bats 
      captured at Kasokero Cave, Uganda. During virus characterization studies at the 
      institute, 4 laboratory-associated infections resulted in mild to severe disease. 
      Although orthonairoviruses are typically associated with vertebrate and tick 
      hosts, a tick vector of KASV never has been reported. We tested 786 Ornithodoros 
      (Reticulinasus) faini tick pools (3,930 ticks) for KASV. The ticks were collected 
      from a large R. aegyptiacus bat roosting site in western Uganda. We detected KASV 
      RNA in 43 tick pools and recovered 2 infectious isolates, 1 of which was derived 
      from host blood-depleted ticks. Our findings suggest that KASV is maintained in 
      an enzootic transmission cycle involving O. (R.) faini ticks and R. aegyptiacus 
      bats and has the potential for incidental virus spillover to humans.
FAU - Schuh, Amy J
AU  - Schuh AJ
FAU - Amman, Brian R
AU  - Amman BR
FAU - Patel, Ketan
AU  - Patel K
FAU - Sealy, Tara K
AU  - Sealy TK
FAU - Swanepoel, Robert
AU  - Swanepoel R
FAU - Towner, Jonathan S
AU  - Towner JS
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Emerg Infect Dis
JT  - Emerging infectious diseases
JID - 9508155
SB  - IM
MH  - Animals
MH  - *Bunyaviridae
MH  - *Chiroptera
MH  - Humans
MH  - *Ornithodoros
MH  - Phylogeny
MH  - Uganda/epidemiology
MH  - *Viruses
PMC - PMC7706932
OTO - NOTNLM
OT  - Argasidae
OT  - Chiroptera
OT  - Ornithodoros
OT  - Rousettus
OT  - Uganda
OT  - Viruses
OT  - arboviruses
OT  - bats
OT  - ecology
OT  - nairoviruses
OT  - ticks
OT  - vector-borne infections
EDAT- 2020/11/22 06:00
MHDA- 2021/05/27 06:00
PMCR- 2020/12/01
CRDT- 2020/11/21 08:33
PHST- 2020/11/21 08:33 [entrez]
PHST- 2020/11/22 06:00 [pubmed]
PHST- 2021/05/27 06:00 [medline]
PHST- 2020/12/01 00:00 [pmc-release]
AID - 20-2411 [pii]
AID - 10.3201/eid2612.202411 [doi]
PST - ppublish
SO  - Emerg Infect Dis. 2020 Dec;26(12):2944-2950. doi: 10.3201/eid2612.202411.