PMID- 33221157
OWN - NLM
STAT- MEDLINE
DCOM- 20220118
LR  - 20220421
IS  - 1096-0023 (Electronic)
IS  - 1043-4666 (Print)
IS  - 1043-4666 (Linking)
VI  - 138
DP  - 2021 Feb
TI  - Short-term effect of non-surgical periodontal treatment on local and systemic 
      cytokine levels: Role of hyperglycemia.
PG  - 155360
LID - S1043-4666(20)30376-8 [pii]
LID - 10.1016/j.cyto.2020.155360 [doi]
AB  - BACKGROUND: The effect of non-surgical periodontal treatment on oral and systemic 
      inflammatory mediators in subjects with periodontitis and hyperglycemia remains 
      largely unknown. Therefore, the aim of this clinical study was to compare the 
      short-term effect of non-surgical periodontal treatment on serum, saliva and GCF 
      inflammatory markers levels in GP subjects with or without hyperglycemia. 
      METHODS: Sixty subjects divided into four groups of equal size were selected to 
      participate: type 2 diabetics with generalized periodontitis (T2DM + GP), 
      pre-diabetics with GP (PD + GP), normoglycemic subjects with GP (NG + GP), and 
      healthy controls. GCF, serum, and saliva samples were obtained at baseline and 
      30 days after scaling and root planning (SRP) and the levels of interleukin-1beta 
      (IL-1 beta), IL-8, IL-6, IL-2, IL-5, IL-4, IL-10, Interferon gamma (IFN-gamma), 
      Granulocyte macrophage colony-stimulating factor (GM-CSF) and Tumor necrosis 
      factor-alpha (TNF-alpha) were determined by ultrasensitive multiplex assay. Clinical 
      periodontal measurements were recorded. RESULTS: SRP yielded significant 
      improvement of all periodontal parameters for all GP groups (p < 0.01). A 
      significant reduction in GCF levels of several cytokines were observed; however, 
      only IL-1B and IFN-gamma were consistently reduced post-treatment across all GP 
      groups. Salivary levels of IL-1beta were significantly reduced in all GP groups 
      following treatment. No significant differences were observed for serum levels 
      after SRP. CONCLUSIONS: Periodontal treatment reduced local inflammatory markers, 
      specifically IL-1B and IFN-gamma, irrespective of the diabetes status. Periodontal 
      treatment had no significant effect on serum levels of the inflammatory markers 
      evaluated in this study.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Rabelo, Mariana de Sousa
AU  - Rabelo MS
AD  - Department of Stomatology, Division of Periodontics, School of Dentistry, 
      University of Sao Paulo, Sao Paulo, Brazil; Department of Periodontics, The 
      Dental College of Georgia, Augusta University, Augusta, USA.
FAU - Gomes, Giovane Hisse
AU  - Gomes GH
AD  - Department of Stomatology, Division of Periodontics, School of Dentistry, 
      University of Sao Paulo, Sao Paulo, Brazil.
FAU - Foz, Adriana Moura
AU  - Foz AM
AD  - Department of Stomatology, Division of Periodontics, School of Dentistry, 
      University of Sao Paulo, Sao Paulo, Brazil.
FAU - Stadler, Amanda Finger
AU  - Stadler AF
AD  - Division of Comprehensive Oral Health, Periodontology, Adams School of Dentistry, 
      University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
FAU - Cutler, Christopher W
AU  - Cutler CW
AD  - Department of Periodontics, The Dental College of Georgia, Augusta University, 
      Augusta, USA.
FAU - Susin, Cristiano
AU  - Susin C
AD  - Division of Comprehensive Oral Health, Periodontology, Adams School of Dentistry, 
      University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
FAU - Romito, Giuseppe Alexandre
AU  - Romito GA
AD  - Department of Stomatology, Division of Periodontics, School of Dentistry, 
      University of Sao Paulo, Sao Paulo, Brazil. Electronic address: garomito@usp.br.
LA  - eng
GR  - R01 DE014328/DE/NIDCR NIH HHS/United States
GR  - R21 DE020916/DE/NIDCR NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20201119
PL  - England
TA  - Cytokine
JT  - Cytokine
JID - 9005353
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Cytokines)
RN  - 0 (Inflammation Mediators)
SB  - IM
MH  - Administration, Oral
MH  - Adult
MH  - Aged
MH  - Biomarkers/metabolism
MH  - Blood Glucose/analysis
MH  - Cytokines/*metabolism
MH  - Diabetes Mellitus, Type 2/*metabolism
MH  - Female
MH  - Gingival Crevicular Fluid/chemistry/*metabolism
MH  - Humans
MH  - Hyperglycemia/*metabolism
MH  - Inflammation
MH  - Inflammation Mediators
MH  - Male
MH  - Middle Aged
MH  - Periodontitis/*metabolism
MH  - Saliva/chemistry
MH  - Time Factors
PMC - PMC7855216
MID - NIHMS1647620
OTO - NOTNLM
OT  - Cytokines
OT  - Gingival crevicular fluid
OT  - Inflammation
OT  - Periodontal disease
OT  - Pre-diabetes
OT  - Saliva
OT  - Serum
OT  - Type 2 diabetes mellitus
COIS- Declaration of interests The authors declare that they have no known competing 
      financial interests or personal relationships that could have appeared to 
      influence the work reported in this paper.
EDAT- 2020/11/23 06:00
MHDA- 2022/01/19 06:00
PMCR- 2022/02/01
CRDT- 2020/11/22 20:32
PHST- 2020/06/07 00:00 [received]
PHST- 2020/10/14 00:00 [revised]
PHST- 2020/10/31 00:00 [accepted]
PHST- 2020/11/23 06:00 [pubmed]
PHST- 2022/01/19 06:00 [medline]
PHST- 2020/11/22 20:32 [entrez]
PHST- 2022/02/01 00:00 [pmc-release]
AID - S1043-4666(20)30376-8 [pii]
AID - 10.1016/j.cyto.2020.155360 [doi]
PST - ppublish
SO  - Cytokine. 2021 Feb;138:155360. doi: 10.1016/j.cyto.2020.155360. Epub 2020 Nov 19.