PMID- 33221611
OWN - NLM
STAT- MEDLINE
DCOM- 20210104
LR  - 20210104
IS  - 1532-8511 (Electronic)
IS  - 1052-3057 (Linking)
VI  - 30
IP  - 1
DP  - 2021 Jan
TI  - The Association Between Apolipoprotein E Gene Polymorphism and In-Stent 
      Restenosis After Extracranial and Intracranial Artery Stenting.
PG  - 105424
LID - S1052-3057(20)30842-9 [pii]
LID - 10.1016/j.jstrokecerebrovasdis.2020.105424 [doi]
AB  - BACKGROUND AND PURPOSE: Neo-atherosclerosis plays a vital role in the incidence 
      of in-stent restenosis (ISR) after extracranial and intracranial artery stenting, 
      and Apolipoprotein (ApoE) gene polymorphism has been reported to be closely 
      related to the occurrence and development of atherosclerosis. The present study 
      aims to investigate the association between ApoE gene polymorphism and ISR after 
      extracranial and intracranial artery stenting. METHODS: A total of 169 patients 
      with successful stent implantation were included in this study. ApoE genotypes 
      were obtained during the postoperative follow-up. Color Doppler ultrasonography 
      of cervical artery or head and neck CT angiography (CTA) was performed on the 
      1,3,6 and 12 months and then yearly in the clinical follow-up. Multivariate Cox 
      regression analysis of independent risk factors was performed to evaluate the 
      ISR. Kaplan-Meier curves were generated to compare the restenosis -free rate 
      among the patients with different ApoE genotypes. RESULTS: Of the 169 patients, 
      43 (43/169, 25.4%) developed ISR after a mean follow-up period of 10.4 months 
      (1-35 months). Multivariate analysis showed that genotype E4/E4 (hazard ratio 
      3.305, P = 0.031, 95% confidence interval 1.118-9.773) and degree of stenosis 
      >90% (hazard ratio 5.083, P = 0.001, 95% confidence interval 1.938-13.327) were 
      significant determinants of ISR. CONCLUSION: ApoE gene polymorphism is closely 
      related to the incidence of ISR after extracranial and intracranial artery 
      stenting, and the genotype E4/E4 is an independent risk factor for ISR.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Kang, Zhoucheng
AU  - Kang Z
AD  - Department of Neurology, Xijing Hospital, The Fourth Military Medical University, 
      15 Changle West Road, Xi'an, Shanxi 710032, P.R. China.
FAU - Cao, Yuhong
AU  - Cao Y
AD  - Department of Neurology, Air Force Medical Center, 30 Fucheng Road, Haidian 
      District, Beijing 100142, P.R. China. Electronic address: caoyh70@126.com.
FAU - Li, Li
AU  - Li L
AD  - Department of Neurology, Air Force Medical Center, 30 Fucheng Road, Haidian 
      District, Beijing 100142, P.R. China. Electronic address: lilee@263.net.
FAU - Zhang, Guangyun
AU  - Zhang G
AD  - Department of Neurology, Air Force Medical Center, 30 Fucheng Road, Haidian 
      District, Beijing 100142, P.R. China. Electronic address: zhgyunfmmu@163.com.
LA  - eng
PT  - Journal Article
DEP - 20201119
PL  - United States
TA  - J Stroke Cerebrovasc Dis
JT  - Journal of stroke and cerebrovascular diseases : the official journal of National 
      Stroke Association
JID - 9111633
RN  - 0 (ApoE protein, human)
RN  - 0 (Apolipoproteins E)
SB  - IM
MH  - Aged
MH  - Apolipoproteins E/*genetics
MH  - Carotid Stenosis/diagnostic imaging/genetics/*therapy
MH  - Databases, Factual
MH  - Endovascular Procedures/*adverse effects/*instrumentation
MH  - Female
MH  - Humans
MH  - Ischemic Stroke/diagnostic imaging/genetics/*therapy
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Progression-Free Survival
MH  - Recurrence
MH  - Registries
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - *Stents
OTO - NOTNLM
OT  - Apolipoprotein E
OT  - Gene polymorphism
OT  - In-stent restenosis
OT  - Stroke
COIS- Declaration of Competing Interest None.
EDAT- 2020/11/23 06:00
MHDA- 2021/01/05 06:00
CRDT- 2020/11/22 20:37
PHST- 2020/07/14 00:00 [received]
PHST- 2020/10/14 00:00 [revised]
PHST- 2020/10/20 00:00 [accepted]
PHST- 2020/11/23 06:00 [pubmed]
PHST- 2021/01/05 06:00 [medline]
PHST- 2020/11/22 20:37 [entrez]
AID - S1052-3057(20)30842-9 [pii]
AID - 10.1016/j.jstrokecerebrovasdis.2020.105424 [doi]
PST - ppublish
SO  - J Stroke Cerebrovasc Dis. 2021 Jan;30(1):105424. doi: 
      10.1016/j.jstrokecerebrovasdis.2020.105424. Epub 2020 Nov 19.