PMID- 33221959
OWN - NLM
STAT- MEDLINE
DCOM- 20210423
LR  - 20230510
IS  - 1438-8359 (Electronic)
IS  - 0913-8668 (Linking)
VI  - 35
IP  - 1
DP  - 2021 Feb
TI  - Oral carbohydrate solution cause an inflammatory response when aspirated into the 
      lungs in mice.
PG  - 86-92
LID - 10.1007/s00540-020-02873-w [doi]
AB  - PURPOSE: Many studies have been published on the beneficial effects of oral 
      carbohydrate solutions (OCS) administered prior to surgery. However, the risk of 
      pulmonary aspiration cannot be excluded in all patients undergoing anesthesia. 
      But, there are few studies on the safety of OCS at lung aspiration. METHODS: 
      Experiments were conducted with mice (Nine- to ten-week-old male BALB/c mice 
      weighted 23-26 g). Lung aspiration was performed by intratracheal administration 
      of OCS and its major constituents, fructose and maltodextrin. Bronchoalveolar 
      lavage fluid (BALF) was collected 3 and 24 h after lung aspiration. The level of 
      Tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and macrophage inflammatory 
      protein-2 (MIP-2) were measured in BALF. The total white blood cell, neutrophil 
      counts, wet to dry ratio and histological examination were performed in BALF and 
      lung tissue, respectively, at 24 h after aspiration. RESULTS: The OCS increased 
      the level of TNF-alpha, IL-6 and MIP-2 at 3 h and the neutrophil count at 24 h in 
      BALFs, compared to a phosphate-buffered saline (PBS) group. The increase in IL-6 
      level induced by OCS was maintained for 24 h. The OCS also increased the number 
      of white blood cells and the percentage of neutrophils in BALFs. Compared to 
      fructose, maltodextrin significantly increased the production of MIP-2 in BALFs. 
      OCS and maltodextrin also increased neutrophil recruitment in lung tissue. 
      CONCLUSION: Aspiration of OCS may cause inflammation of the lungs. The 
      preoperative use of OCS may require caution under specific clinical conditions, 
      such as patients at risk of lung aspiration.
FAU - Kim, Joungmin
AU  - Kim J
AD  - Department of Anesthesiology and Pain Medicine, Chonnam National University 
      Medical School, Chonnam National University Hospital, 160, Baekseo-ro, Dong-gu, 
      Gwangju, 501-746, Korea.
FAU - Kim, Hyung-Seok
AU  - Kim HS
AD  - Department of Forensic Medicine, Chonnam National University Medical School, 
      Hwasun, Korea.
FAU - Kim, Minji
AU  - Kim M
AD  - Department of Anesthesiology and Pain Medicine, Chonnam National University 
      Medical School, Chonnam National University Hospital, 160, Baekseo-ro, Dong-gu, 
      Gwangju, 501-746, Korea.
FAU - Bae, Hong-Beom
AU  - Bae HB
AUID- ORCID: 0000-0002-0358-6807
AD  - Department of Anesthesiology and Pain Medicine, Chonnam National University 
      Medical School, Chonnam National University Hospital, 160, Baekseo-ro, Dong-gu, 
      Gwangju, 501-746, Korea. nextphil2@jnu.ac.kr.
FAU - Choi, Jeong-Il
AU  - Choi JI
AD  - Department of Anesthesiology and Pain Medicine, Chonnam National University 
      Medical School, Chonnam National University Hospital, 160, Baekseo-ro, Dong-gu, 
      Gwangju, 501-746, Korea. jichoi@jnu.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201122
PL  - Japan
TA  - J Anesth
JT  - Journal of anesthesia
JID - 8905667
RN  - 0 (Carbohydrates)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Bronchoalveolar Lavage Fluid
MH  - Carbohydrates
MH  - Humans
MH  - *Lung
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Neutrophils
MH  - *Tumor Necrosis Factor-alpha
OTO - NOTNLM
OT  - Aspiration pneumonia
OT  - Fructose
OT  - Maltodextrin
OT  - Oral carbohydrate solution
OT  - Preoperative fasting
EDAT- 2020/11/23 06:00
MHDA- 2021/04/24 06:00
CRDT- 2020/11/22 20:43
PHST- 2020/04/01 00:00 [received]
PHST- 2020/11/02 00:00 [accepted]
PHST- 2020/11/23 06:00 [pubmed]
PHST- 2021/04/24 06:00 [medline]
PHST- 2020/11/22 20:43 [entrez]
AID - 10.1007/s00540-020-02873-w [pii]
AID - 10.1007/s00540-020-02873-w [doi]
PST - ppublish
SO  - J Anesth. 2021 Feb;35(1):86-92. doi: 10.1007/s00540-020-02873-w. Epub 2020 Nov 
      22.