PMID- 33222971
OWN - NLM
STAT- MEDLINE
DCOM- 20210208
LR  - 20210208
IS  - 1532-2653 (Electronic)
IS  - 0967-5868 (Linking)
VI  - 81
DP  - 2020 Nov
TI  - The effect of folate and VitB(12) in the treatment of MCI patients with 
      hyperhomocysteinemia.
PG  - 65-69
LID - S0967-5868(20)31522-8 [pii]
LID - 10.1016/j.jocn.2020.09.043 [doi]
AB  - OBJECTIVE: This study aims to investigate the effect of folate combined with 
      VitB(12) on serum total homocysteine (tHcy) levels and cognitive function in 
      patients with mild cognitive impairment (MCI) complicated by hyperhomocysteinemia 
      (HHcy). METHODS: (1) A total of 92 MCI patients with HHcy were enrolled in this 
      study and randomly divided into two groups: the intervention group (46 cases) and 
      the control group (46 cases). (2) The patients in both groups received the 
      routine treatment for their condition, but patients in the intervention group 
      were also given 5 mg/day of folate and 500 mug x 3/day of VitB(12). (3) The 
      changes in levels of folate, VitB(12), and tHcy, the Montreal Cognitive 
      Assessment (MoCA) score and the event-related potential (P300) were observed 
      before and after treatment. RESULTS: (1) There were no statistically significant 
      differences in folate, VitB(12), and tHcy levels, the MoCA score and the P300 
      between the two groups before treatment. (2) At the 4th, 12th and 24th week, 
      folate and VitB(12) levels in the intervention group were higher than those in 
      the same group before treatment and those in the control group at the same time 
      points, while tHcy levels were lower than those in the same group before 
      treatment and those in the control group at the same time points. (3) At the 24th 
      week, the MoCA score in the control group was lower than before treatment, and 
      the MoCA score in the intervention group was higher than in the same group before 
      treatment and in the control group at the same time point. The P300 latency was 
      shorter than it was in the same group before treatment and in the control group 
      at the same time point. CONCLUSION: Folate and VitB(12) can effectively reduce 
      levels of tHcy in patients with MCI and improve cognitive function.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Jiang, Bo
AU  - Jiang B
AD  - Department of Neurology, Fourth Medical Center, Chinese PLA General Hospital. 
      Beijing 100048, China. Electronic address: bojiangcn@126.com.
FAU - Yao, Guoen
AU  - Yao G
AD  - Department of Neurology, Fourth Medical Center, Chinese PLA General Hospital. 
      Beijing 100048, China.
FAU - Yao, Cunshan
AU  - Yao C
AD  - Department of Neurology, Fourth Medical Center, Chinese PLA General Hospital. 
      Beijing 100048, China.
FAU - Zheng, Na
AU  - Zheng N
AD  - Department of Neurology, Fourth Medical Center, Chinese PLA General Hospital. 
      Beijing 100048, China.
LA  - eng
PT  - Journal Article
DEP - 20200929
PL  - Scotland
TA  - J Clin Neurosci
JT  - Journal of clinical neuroscience : official journal of the Neurosurgical Society 
      of Australasia
JID - 9433352
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 935E97BOY8 (Folic Acid)
RN  - P6YC3EG204 (Vitamin B 12)
SB  - IM
MH  - Aged
MH  - Cognition/*drug effects/physiology
MH  - Cognitive Dysfunction/blood/*drug therapy/epidemiology
MH  - Drug Therapy, Combination
MH  - Female
MH  - Folic Acid/*administration & dosage/blood
MH  - Homocysteine/blood
MH  - Humans
MH  - Hyperhomocysteinemia/blood/*drug therapy/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Treatment Outcome
MH  - Vitamin B 12/*administration & dosage/blood
OTO - NOTNLM
OT  - Folic acid
OT  - Homocysteine
OT  - Mild cognitive impairment
OT  - VitB(12)
EDAT- 2020/11/24 06:00
MHDA- 2021/02/09 06:00
CRDT- 2020/11/23 05:27
PHST- 2020/06/23 00:00 [received]
PHST- 2020/09/10 00:00 [revised]
PHST- 2020/09/14 00:00 [accepted]
PHST- 2020/11/23 05:27 [entrez]
PHST- 2020/11/24 06:00 [pubmed]
PHST- 2021/02/09 06:00 [medline]
AID - S0967-5868(20)31522-8 [pii]
AID - 10.1016/j.jocn.2020.09.043 [doi]
PST - ppublish
SO  - J Clin Neurosci. 2020 Nov;81:65-69. doi: 10.1016/j.jocn.2020.09.043. Epub 2020 
      Sep 29.