PMID- 33224757
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201124
IS  - 2223-3652 (Print)
IS  - 2223-3660 (Electronic)
IS  - 2223-3652 (Linking)
VI  - 10
IP  - 5
DP  - 2020 Oct
TI  - A case of acute myelogenous leukemia characterized by arterial and venous 
      thrombosis.
PG  - 1332-1340
LID - 10.21037/cdt-20-486 [doi]
AB  - Acute myelogenous leukemia (AML) is a malignant disease of the hematopoietic 
      system, characterized by features of bone marrow insufficiency and organ 
      infiltration by leukemic cells. Venous thrombosis in AML patients is uncommon, 
      compared to bleeding; therefore in patients with AML, simultaneous occurrence of 
      venous and arterial thrombosis is a rather rare presentation. We reported an 
      unusual case of anti-phospholipid antibody syndrome secondary to AML 
      characterized by venous and arterial thrombosis. A 70-year-old man with deep 
      venous thrombosis (DVT) of the left leg confirmed by Doppler was seen in our 
      clinic. During treatment with a Vitamin K antagonist (3 mg daily of Warfarin) and 
      a low molecular weight heparin (LMWH), he developed an acute pulmonary embolism 
      and an acute inferior wall ST elevation myocardial infarction (STEMI), a result 
      of right coronary artery embolism. His full blood count showed leukocytosis and 
      thrombocytopenia. Lupus anticoagulant and anti-cardiolipin antibodies were 
      positive. A bone marrow aspirate test showed results consistent with AML (FAB 
      class M1). A diagnosis of antiphospholipid antibody syndrome secondary to AML 
      characterized by coronary artery embolism, pulmonary embolism and left leg DVT 
      was eventually established. He received anticoagulation with a low dose of 
      warfarin after refusing chemotherapy. He however died of cerebral hemorrhage 
      despite the fact that the INR was in the normal therapeutic range. It is 
      challenging to anticoagulated AML patients complicated by multiple vascular 
      thromboses and thrombocytopenia.
CI  - 2020 Cardiovascular Diagnosis and Therapy. All rights reserved.
FAU - Liang, Huasheng
AU  - Liang H
AD  - Department of Cardiology, Guangdong Provincial People's Hospital's Nanhai 
      Hospital, Foshan, China.
FAU - Ba, Mingchuan
AU  - Ba M
AD  - Department of Cardiology, Guangdong Provincial People's Hospital's Nanhai 
      Hospital, Foshan, China.
FAU - Li, Chen
AU  - Li C
AD  - Department of Cardiology, Guangdong Provincial People's Hospital's Nanhai 
      Hospital, Foshan, China.
FAU - Li, Haoping
AU  - Li H
AD  - Department of Cardiology, Guangdong Provincial People's Hospital's Nanhai 
      Hospital, Foshan, China.
FAU - Guo, Zhiqiang
AU  - Guo Z
AD  - Department of Cardiology, Guangdong Provincial People's Hospital's Nanhai 
      Hospital, Foshan, China.
FAU - He, Pengcheng
AU  - He P
AD  - Department of Cardiology, Guangdong Provincial People's Hospital's Nanhai 
      Hospital, Foshan, China.
AD  - Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong 
      Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 
      China.
FAU - Lin, Chunying
AU  - Lin C
AD  - Department of Cardiology, Guangdong Provincial People's Hospital's Nanhai 
      Hospital, Foshan, China.
LA  - eng
PT  - Case Reports
PL  - China
TA  - Cardiovasc Diagn Ther
JT  - Cardiovascular diagnosis and therapy
JID - 101601613
PMC - PMC7666938
OTO - NOTNLM
OT  - Acute myelogenous leukemia (AML)
OT  - acute myocardial infarction
OT  - antiphospholipid antibody syndrome
OT  - deep venous thrombosis (DVT)
OT  - pulmonary embolism
COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure 
      form (available at http://dx.doi.org/10.21037/cdt-20-486). The authors have no 
      conflicts of interest to declare.
EDAT- 2020/11/24 06:00
MHDA- 2020/11/24 06:01
PMCR- 2020/10/01
CRDT- 2020/11/23 05:40
PHST- 2020/11/23 05:40 [entrez]
PHST- 2020/11/24 06:00 [pubmed]
PHST- 2020/11/24 06:01 [medline]
PHST- 2020/10/01 00:00 [pmc-release]
AID - cdt-10-05-1332 [pii]
AID - 10.21037/cdt-20-486 [doi]
PST - ppublish
SO  - Cardiovasc Diagn Ther. 2020 Oct;10(5):1332-1340. doi: 10.21037/cdt-20-486.