PMID- 33225189
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201124
IS  - 2470-1343 (Electronic)
IS  - 2470-1343 (Linking)
VI  - 5
IP  - 45
DP  - 2020 Nov 17
TI  - Highly Stable and Fine-Textured Hybrid Microspheres for Entrapment of Cosmetic 
      Active Ingredients.
PG  - 29577-29584
LID - 10.1021/acsomega.0c04609 [doi]
AB  - This study details the preparation and application of supramolecular host-guest 
      inclusion complexes entrapping biomineralized microspheres for long-term storage 
      and their pH-responsive behavior. The microspheres were assembled using a CaCO(3) 
      synthesis process coupled with cyclodextrin-tetrahydrocurcumin (CD-THC) inclusion 
      complexes, forming fine-textured and mechanically stable hybrid materials. The 
      products were successfully characterized using field-emission scanning electron 
      microscopy (FE-SEM), energy-dispersive X-ray spectroscopy (EDS), Fourier 
      transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), and particle 
      size analysis (PSA). Various parameters such as the Brunauer-Emmett-Teller (BET) 
      surface area, single point total pore volume, and pore size via 
      adsorption/desorption analysis were also determined. The obtained THC-entrapped 
      hybrid microspheres contained as high as 20 wt % THC loading and were very 
      stable, preserving 90% of the initial concentration over four weeks of storage at 
      different temperatures, largely limiting THC leaching and indicating high 
      stability in a physiological environment. In addition, the pH-responsive release 
      of THC from the hybrid microspheres was observed, showing potential use for 
      application to weakly acidic skin surfaces. To our knowledge, this is the first 
      demonstration of antiaging cosmetic formulation technology using 
      biomineralization based on the co-synthesis of CaCO(3) and CD-THC complexes.
CI  - (c) 2020 American Chemical Society.
FAU - Hwang, Ee Taek
AU  - Hwang ET
AD  - Department of Food Biotechnology, Dong-A University, Busan 49315, Republic of 
      Korea.
FAU - Lee, Seonbyul
AU  - Lee S
AD  - Center for Convergence Bioceramic Materials, Korea Institute of Ceramic 
      Engineering & Technology, Cheongju-si, Chungcheongbuk-do 28160, Republic of 
      Korea.
FAU - Kim, Jung Soo
AU  - Kim JS
AD  - R&D Center, ACT Co., Ltd., Suwon, Gyeonggi-do 16506, Republic of Korea.
FAU - Jeong, Jinhee
AU  - Jeong J
AD  - Symbiose Cosmetics, Seongnam-si, Gyeonggi-do 13555, Republic of Korea.
FAU - Jeon, Byoung Seung
AU  - Jeon BS
AD  - Environmental Biotechnology Group, Center for Applied Geosciences, University of 
      Tubingen, Tubingen 72076, Germany.
FAU - Lee, Jae Won
AU  - Lee JW
AD  - Korea Conformity Laboratories, Incheon 21999, Republic of Korea.
FAU - Kim, Joong Hyun
AU  - Kim JH
AD  - Clinical Drug Manufacturing Center, Daegu-Gyeongbuk Medical Innovation 
      Foundation, Daegu 41061, Republic of Korea.
FAU - Kim, Jangyong
AU  - Kim J
AD  - School of Information Science and Technology, ShanghaiTech University, Shanghai 
      201210, China.
LA  - eng
PT  - Journal Article
DEP - 20201103
PL  - United States
TA  - ACS Omega
JT  - ACS omega
JID - 101691658
PMC - PMC7676303
COIS- The authors declare no competing financial interest.
EDAT- 2020/11/24 06:00
MHDA- 2020/11/24 06:01
PMCR- 2020/11/03
CRDT- 2020/11/23 05:42
PHST- 2020/09/19 00:00 [received]
PHST- 2020/10/23 00:00 [accepted]
PHST- 2020/11/23 05:42 [entrez]
PHST- 2020/11/24 06:00 [pubmed]
PHST- 2020/11/24 06:01 [medline]
PHST- 2020/11/03 00:00 [pmc-release]
AID - 10.1021/acsomega.0c04609 [doi]
PST - epublish
SO  - ACS Omega. 2020 Nov 3;5(45):29577-29584. doi: 10.1021/acsomega.0c04609. 
      eCollection 2020 Nov 17.