PMID- 33225207
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220418
IS  - 2515-5091 (Electronic)
IS  - 2515-5091 (Linking)
VI  - 4
IP  - 5
DP  - 2020 Oct
TI  - Racial and Ethnic Disparities Among Participants in US-Based Phase 3 Randomized 
      Cancer Clinical Trials.
PG  - pkaa060
LID - 10.1093/jncics/pkaa060 [doi]
LID - pkaa060
AB  - Although improving representation of racial and ethnic groups in United States 
      clinical trials has been a focus of federal initiatives for nearly 3 decades, the 
      status of racial and ethnic minority enrollment on cancer trials is largely 
      unknown. We used a broad collection of phase 3 cancer trials derived from 
      ClinicalTrials.gov to evaluate racial and ethnic enrollment among US cancer 
      trials. The difference in incidence by race and ethnicity was the median absolute 
      difference between trial and corresponding Surveillance, Epidemiology, and End 
      Results data. All statistical tests were 2-sided. Using a cohort of 168 eligible 
      trials, median difference in incidence by race and ethnicity was +6.8% for Whites 
      (interquartile range [IQR] = +1.8% to +10.1%; P < .001 by Wilcoxon signed-rank 
      test comparing median difference in incidence by race and ethnicity to a value of 
      0), -2.6% for Blacks (IQR = -5.1% to +1.2%; P = .004), -4.7% for Hispanics (IQR = 
      -7.5% to -0.3%; P < .001), and -4.7% for Asians (IQR = -5.7% to -3.3%; P < .001). 
      These data demonstrate overrepresentation of Whites, with continued 
      underrepresentation of racial and ethnic minority subgroups.
CI  - (c) The Author(s) 2020. Published by Oxford University Press.
FAU - Grant, Stephen R
AU  - Grant SR
AD  - The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
FAU - Lin, Timothy A
AU  - Lin TA
AD  - The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
FAU - Miller, Austin B
AU  - Miller AB
AD  - The University of Texas Health Science Center McGovern Medical School, Houston, 
      TX, USA.
FAU - Mainwaring, Walker
AU  - Mainwaring W
AD  - Baylor College of Medicine, Houston, TX, USA.
FAU - Espinoza, Andres F
AU  - Espinoza AF
AD  - Baylor College of Medicine, Houston, TX, USA.
FAU - Jethanandani, Amit
AU  - Jethanandani A
AD  - The University of Tennessee Health Science Center College of Medicine, Memphis, 
      TN, USA.
FAU - Walker, Gary V
AU  - Walker GV
AD  - Banner MD Anderson Cancer Center, Gilbert, AZ, USA.
FAU - Smith, Benjamin D
AU  - Smith BD
AD  - The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
FAU - Ashleigh Guadagnolo, B
AU  - Ashleigh Guadagnolo B
AD  - The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
FAU - Jagsi, Reshma
AU  - Jagsi R
AD  - The University of Michigan, Ann Arbor, MI, USA.
FAU - David Fuller, C
AU  - David Fuller C
AD  - The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
AD  - Oregon Health & Science University, Portland, OR, USA.
FAU - Thomas, Charles R Jr
AU  - Thomas CR Jr
AD  - Oregon Health & Science University, Portland, OR, USA.
FAU - Ludmir, Ethan B
AU  - Ludmir EB
AD  - The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
LA  - eng
PT  - Comment
PT  - Journal Article
DEP - 20200707
PL  - England
TA  - JNCI Cancer Spectr
JT  - JNCI cancer spectrum
JID - 101721827
CON - JNCI Cancer Spectr. 2020 Jul 07;4(5):pkaa059. PMID: 33134834
PMC - PMC7667997
EDAT- 2020/11/24 06:00
MHDA- 2020/11/24 06:01
PMCR- 2020/07/07
CRDT- 2020/11/23 05:42
PHST- 2020/03/27 00:00 [received]
PHST- 2020/06/18 00:00 [revised]
PHST- 2020/06/26 00:00 [accepted]
PHST- 2020/11/23 05:42 [entrez]
PHST- 2020/11/24 06:00 [pubmed]
PHST- 2020/11/24 06:01 [medline]
PHST- 2020/07/07 00:00 [pmc-release]
AID - pkaa060 [pii]
AID - 10.1093/jncics/pkaa060 [doi]
PST - epublish
SO  - JNCI Cancer Spectr. 2020 Jul 7;4(5):pkaa060. doi: 10.1093/jncics/pkaa060. 
      eCollection 2020 Oct.