PMID- 33225648
OWN - NLM
STAT- MEDLINE
DCOM- 20210105
LR  - 20231213
IS  - 1819-2718 (Electronic)
IS  - 1025-9589 (Linking)
VI  - 32
IP  - 4
DP  - 2020 Oct-Dec
TI  - Secretory Carcinoma Of Salivary Gland: A Clincopathological Analysis.
PG  - 481-486
AB  - BACKGROUND: Secretory carcinoma of the salivary gland (SC) is a new entity that 
      harbours a specific ETV6 gene rearrangement. The clinical behaviour of this 
      tumour is not well-known as it is a relatively new entity but it is generally 
      considered as a tumour of low malignant potential. The objective of the study was 
      to find out the frequency of ETV6 translocation in cases diagnosed based on 
      histology and immunohistochemistry, to study morphological features and 
      immunohistochemical findings of our cases and to determine the survival and 
      disease-free status of our patients. METHODS: Twenty-five diagnosed cases of SC 
      were retrieved from the archives of SKMCH and RC. Diagnosis was made primarily 
      based on morphology and immunohistochemistry. Immunohistochemistry includes S100, 
      p63, mammaglobin, DOG 1, GCDFP-15, TTF-1, GATA3, SMA, AMA, and AR. The diagnosis 
      was further confirmed by molecular testing, i.e., Fluorescence in situ 
      hybridization (FISH) studies to observe specific ETV6 gene break. Follow up of 
      the patients was done by developing a questionnaire. Statistical analysis of the 
      data was done using SPSS-23.0. RESULTS: The mean age of diagnosis was 41+/-17.4 and 
      the male to female ratio was 1.5:15. The mean size of the tumour was 45.48+/-27.35. 
      The most common site of the tumour was parotid gland (60%). On morphology, SC 
      showed a wide range of morphological patterns, most common being the tubular, 
      microcystic, intraductal, and papillary. Immunohistochemical stains mammaglobin 
      (22/22), GCDFP-15(15/15) and GATA3 (10/10) showed 100% positive result. However, 
      all cases were negative for p63 (0/18) and DOG 1(0/11). ETV6 break was seen in 
      17/17 cases (100%). The mean disease-free survival was 75 months and the overall 
      survival was 51.90+/-2.80 months. CONCLUSIONS: This study highlights the presence 
      of specific molecular alteration in all cases, which were diagnosed based on 
      morphology and immunohistochemistry.
FAU - Akhtar, Noreen
AU  - Akhtar N
AD  - Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan.
FAU - Atiq, Aribah
AU  - Atiq A
AD  - Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan.
FAU - Loya, Asif
AU  - Loya A
AD  - Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan.
FAU - Hassan, Usman
AU  - Hassan U
AD  - Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan.
FAU - Hussain, Mudassir
AU  - Hussain M
AD  - Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan.
FAU - Abu-Bakar, Muhammad
AU  - Abu-Bakar M
AD  - Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan.
FAU - Mushtaq, Sajid
AU  - Mushtaq S
AD  - Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan.
LA  - eng
PT  - Journal Article
PL  - Pakistan
TA  - J Ayub Med Coll Abbottabad
JT  - Journal of Ayub Medical College, Abbottabad : JAMC
JID - 8910750
RN  - 0 (Proto-Oncogene Proteins c-ets)
RN  - 0 (Repressor Proteins)
SB  - IM
MH  - Adult
MH  - *Carcinoma/genetics/mortality/pathology
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Middle Aged
MH  - Proto-Oncogene Proteins c-ets/genetics
MH  - Repressor Proteins/genetics
MH  - *Salivary Gland Neoplasms/genetics/mortality/pathology
MH  - Translocation, Genetic/genetics
MH  - Young Adult
MH  - ETS Translocation Variant 6 Protein
OTO - NOTNLM
OT  - ETV6
OT  - Secretory carcinoma of Salivary gland
EDAT- 2020/11/24 06:00
MHDA- 2021/01/06 06:00
CRDT- 2020/11/23 05:47
PHST- 2020/11/23 05:47 [entrez]
PHST- 2020/11/24 06:00 [pubmed]
PHST- 2021/01/06 06:00 [medline]
AID - 7076/2965 [pii]
PST - ppublish
SO  - J Ayub Med Coll Abbottabad. 2020 Oct-Dec;32(4):481-486.