PMID- 33225757
OWN - NLM
STAT- MEDLINE
DCOM- 20211115
LR  - 20211115
IS  - 1477-0903 (Electronic)
IS  - 0960-3271 (Linking)
VI  - 40
IP  - 5
DP  - 2021 May
TI  - Alpha-lipoic acid ameliorates cytarabine-induced developmental anomalies in rat 
      fetus.
PG  - 851-868
LID - 10.1177/0960327120975114 [doi]
AB  - Cytarabine (Ara-C) is a nucleoside analogue used in the treatment of cancers and 
      viral infections. It has teratogenic potential and causes a variety of birth 
      defects in fetuses. Alpha-lipoic acid (ALA) is a natural antioxidant offers 
      protection against the developmental toxicity induced by drug- or 
      toxicant-exposure or pathological conditions. This study was aimed at evaluating 
      the protective effect of ALA against Ara-C induced developmental toxicity in rat 
      fetus. Pregnant rats divided into five groups and received normal saline, ALA200 
      mg/kg, Ara-C12.5 mg/kg, Ara-C25 mg/kg and, Ara-C25 mg/kg plus ALA200 mg/kg 
      respectively from gestational day (GD) 8 to GD14 and sacrificed on GD21. Ara-C 
      treatment led to a significant and dose-dependent decrease in food intake, weight 
      gain, placental weight, and an increase in oxidative stress in pregnant rats. 
      Further, the in-utero exposure to Ara-C led to an increase in fetal mortality, 
      resorptions, oxidative stress, external morphological anomalies and limb 
      abnormalities, and impaired ossification. Co-administration of ALA resulted in 
      amelioration of the footprints of Ara-C induced toxicity in pregnant rats as well 
      as the fetus. These findings indicate that the ALA supplementation offers 
      protection against developmental toxicity caused by Ara-C prenatal exposure in 
      rats.
FAU - Namoju, Ramanachary
AU  - Namoju R
AUID- ORCID: 0000-0002-1414-3278
AD  - Department of Pharmacology, 78997GITAM Institute of Pharmacy, GITAM Deemed to be 
      University, Vishakhapatnam, Andhra Pradesh, India.
AD  - Department of Pharmacology, Bhaskar Pharmacy College, Jawaharlal Nehru Technical 
      University, Hyderabad, Telangana, India.
FAU - Chilaka, Naga Kavitha
AU  - Chilaka NK
AD  - Department of Pharmacology, 78997GITAM Institute of Pharmacy, GITAM Deemed to be 
      University, Vishakhapatnam, Andhra Pradesh, India.
LA  - eng
PT  - Journal Article
DEP - 20201123
PL  - England
TA  - Hum Exp Toxicol
JT  - Human & experimental toxicology
JID - 9004560
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Protective Agents)
RN  - 04079A1RDZ (Cytarabine)
RN  - 73Y7P0K73Y (Thioctic Acid)
SB  - IM
MH  - Abnormalities, Drug-Induced/*drug therapy
MH  - Animals
MH  - Antineoplastic Agents/*toxicity
MH  - Cytarabine/*metabolism/*toxicity
MH  - Female
MH  - Fetal Development/*drug effects
MH  - Humans
MH  - Models, Animal
MH  - Neoplasms/drug therapy
MH  - Protective Agents/pharmacology/therapeutic use
MH  - Rats
MH  - Thioctic Acid/*pharmacology/*therapeutic use
OTO - NOTNLM
OT  - Cytarabine
OT  - alpha-lipoic acid
OT  - and growth retardation
OT  - developmental toxicity
OT  - skeletal anomalies
OT  - transplacental
EDAT- 2020/11/24 06:00
MHDA- 2021/11/16 06:00
CRDT- 2020/11/23 08:41
PHST- 2020/11/24 06:00 [pubmed]
PHST- 2021/11/16 06:00 [medline]
PHST- 2020/11/23 08:41 [entrez]
AID - 10.1177/0960327120975114 [doi]
PST - ppublish
SO  - Hum Exp Toxicol. 2021 May;40(5):851-868. doi: 10.1177/0960327120975114. Epub 2020 
      Nov 23.