PMID- 33225769 OWN - NLM STAT- MEDLINE DCOM- 20220901 LR - 20220906 IS - 1476-4954 (Electronic) IS - 1476-4954 (Linking) VI - 35 IP - 22 DP - 2022 Nov TI - Procedure-to-delivery interval after late amniocentesis and the need for routine antenatal corticosteroids. PG - 4338-4345 LID - 10.1080/14767058.2020.1849115 [doi] AB - OBJECTIVES: The aim of this study is to assess the procedure-to-delivery interval (PDI), the obstetric complications, and the early neonatal outcome in patients that did or did not receive glucocorticosteroids (GCSs) before third-trimester amniocentesis (TTA). METHODS: A retrospectively analysis of 445 TTA procedures divided into two groups based on the administration (study group = 220 patients) or not (control group = 225 patients) of GCSs before TTA. The PDI was calculated for all patients. Obstetric and neonatal outcomes were compared between the groups. RESULTS: The rate of procedure-associated complications was similar between the groups. The mean PDI was 47.2 +/- 16.8 days. The overall incidence of preterm birth was 11.7%; 9% delivered between 34 and 37 weeks and 2.7% between 28 and 34 weeks. Only nine patients (2%) delivered within seven days following TTA. The incidence of respiratory distress syndrome in the study and control groups was 1.8% and 1.3%, p = .71, respectively. There were no significant differences in other neonatal outcomes in term and preterm deliveries between the study and control groups. CONCLUSIONS: In the present study, the administration of glucocorticoids prior to TTA did not reduce the rates of neonatal complications, which was similar in both groups and not higher than the general population. FAU - Leytes, Sophia AU - Leytes S AD - Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. AD - Department of Obstetrics and Gynecology, Edith Wolfson Medical Center, Holon, Israel. FAU - Haratz, Karina Krajden AU - Haratz KK AUID- ORCID: 0000-0001-9868-3548 AD - Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. AD - Department of Obstetrics and Gynecology, Division of Ultrasound in ObGyn, Lis Maternity Hospital, Tel Aviv Medical Center, Tel Aviv, Israel. FAU - Grin, Leonti AU - Grin L AUID- ORCID: 0000-0002-4552-4428 AD - Department of Obstetrics and Gynecology, Faculty of Health Sciences, Barzilai University Medical Center, Ben-Gurion University of the Negev, Beersheba, Israel. FAU - Shwartz, Tomer AU - Shwartz T AD - Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. FAU - Zohav, Efraim AU - Zohav E AD - Department of Obstetrics and Gynecology, Faculty of Health Sciences, Barzilai University Medical Center, Ben-Gurion University of the Negev, Beersheba, Israel. FAU - Weisz, Boaz AU - Weisz B AD - Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. AD - Ultrasound in Obstetrics and Gynecology Unit, Chaim Sheba Medical Center, Ramat Gan, Israel. FAU - Lipitz, Shlomo AU - Lipitz S AD - Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. AD - Ultrasound in Obstetrics and Gynecology Unit, Chaim Sheba Medical Center, Ramat Gan, Israel. FAU - Maymon, Ron AU - Maymon R AUID- ORCID: 0000-0003-4545-7234 AD - Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. AD - Department of Obstetrics and Gynecology, Shamir Medical Center (Assaf Harofeh), Be'er Ya'akov, Israel. FAU - Bardin, Ron AU - Bardin R AD - Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. AD - Helen Schneider Women's Hospital, Rabin Medical Center, Petah Tikva, Israel. FAU - Gilboa, Yinon AU - Gilboa Y AUID- ORCID: 0000-0002-5266-7769 AD - Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. AD - Helen Schneider Women's Hospital, Rabin Medical Center, Petah Tikva, Israel. FAU - Kleiner, Ilia AU - Kleiner I AD - Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. AD - Department of Obstetrics and Gynecology, Edith Wolfson Medical Center, Holon, Israel. FAU - Kashanian, Alon AU - Kashanian A AUID- ORCID: 0000-0001-8074-0567 AD - Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. FAU - Lev, Dorit AU - Lev D AD - Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. AD - Department of Obstetrics and Gynecology, Edith Wolfson Medical Center, Holon, Israel. FAU - Bar, Jacob AU - Bar J AD - Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. AD - Department of Obstetrics and Gynecology, Edith Wolfson Medical Center, Holon, Israel. FAU - Shalev, Josef AU - Shalev J AD - Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. AD - Department of Obstetrics and Gynecology, Edith Wolfson Medical Center, Holon, Israel. FAU - Gindes, Liat AU - Gindes L AUID- ORCID: 0000-0002-7827-1922 AD - Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. AD - Department of Obstetrics and Gynecology, Edith Wolfson Medical Center, Holon, Israel. LA - eng PT - Journal Article DEP - 20201122 PL - England TA - J Matern Fetal Neonatal Med JT - The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians JID - 101136916 RN - 0 (Adrenal Cortex Hormones) SB - IM MH - Adrenal Cortex Hormones/adverse effects MH - Amniocentesis/adverse effects MH - Female MH - Gestational Age MH - Humans MH - Infant, Newborn MH - Pregnancy MH - *Premature Birth/epidemiology MH - Prenatal Care/methods MH - *Respiratory Distress Syndrome, Newborn/epidemiology/prevention & control MH - Retrospective Studies OTO - NOTNLM OT - Late amniocentesis OT - antenatal corticosteroids OT - neonatal complications OT - preterm delivery OT - respiratory distress syndrome OT - third trimester amniocentesis EDAT- 2020/11/24 06:00 MHDA- 2022/09/02 06:00 CRDT- 2020/11/23 08:41 PHST- 2020/11/24 06:00 [pubmed] PHST- 2022/09/02 06:00 [medline] PHST- 2020/11/23 08:41 [entrez] AID - 10.1080/14767058.2020.1849115 [doi] PST - ppublish SO - J Matern Fetal Neonatal Med. 2022 Nov;35(22):4338-4345. doi: 10.1080/14767058.2020.1849115. Epub 2020 Nov 22.