PMID- 33226962
OWN - NLM
STAT- MEDLINE
DCOM- 20210427
LR  - 20210427
IS  - 1945-4589 (Electronic)
IS  - 1945-4589 (Linking)
VI  - 12
IP  - 23
DP  - 2020 Nov 21
TI  - Caloric restriction: implications for sarcopenia and potential mechanisms.
PG  - 24441-24452
LID - 10.18632/aging.103987 [doi]
AB  - Sarcopenia is a potential risk factor for weakness, disability and death in 
      elderly individuals. Therefore, seeking effective methods to delay and treat 
      sarcopenia and to improve the quality of life of elderly individuals is a 
      trending topic in geriatrics. Caloric restriction (CR) is currently recognized as 
      an effective means to extend the lifespan and delay the decline in organ function 
      caused by aging. In this review, we describe the effects of CR on improving 
      muscle protein synthesis, delaying muscle atrophy, regulating muscle 
      mitochondrial function, maintaining muscle strength, promoting muscle stem cell 
      (MuSC) regeneration and differentiation, and thus protecting against sarcopenia. 
      We also summarize the possible cellular mechanisms by which CR delays sarcopenia. 
      CR can delay sarcopenia by reducing the generation of oxygen free radicals, 
      reducing oxidative stress damage, enhancing mitochondrial function, improving 
      protein homeostasis, reducing iron overload, increasing autophagy and apoptosis, 
      and reducing inflammation. However, the relationships between CR and genetics, 
      sex, animal strain, regimen duration and energy intake level are complex. 
      Therefore, further study of the proper timing and application method of CR to 
      prevent sarcopenia is highly important for the aging population.
FAU - Xie, Wen-Qing
AU  - Xie WQ
AD  - Deparment of Orthopedics, Xiangya Hospital, Central South University, Changsha 
      410008, Hunan, China.
AD  - National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, 
      Central South University, Changsha 410008, Hunan, China.
FAU - Xiao, Wen-Feng
AU  - Xiao WF
AD  - Deparment of Orthopedics, Xiangya Hospital, Central South University, Changsha 
      410008, Hunan, China.
AD  - National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, 
      Central South University, Changsha 410008, Hunan, China.
FAU - Tang, Kun
AU  - Tang K
AD  - Discipline Construction Office, Xiangya Hospital, Central South University, 
      Changsha 410008, Hunan, China.
FAU - Wu, Yu-Xiang
AU  - Wu YX
AD  - School of Kinesiology, Jianghan University, Wuhan 430056, China.
FAU - Hu, Pei-Wu
AU  - Hu PW
AD  - Department of Scientific Research, Xiangya Hospital, Central South University, 
      Changsha 410008, Hunan, China.
FAU - Li, Yu-Sheng
AU  - Li YS
AD  - Deparment of Orthopedics, Xiangya Hospital, Central South University, Changsha 
      410008, Hunan, China.
AD  - National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, 
      Central South University, Changsha 410008, Hunan, China.
FAU - Duan, Yu
AU  - Duan Y
AD  - Department of Geriatric Endocrinology, The First Affiliated Hospital of Nanjing 
      Medical University, Nanjing 210029, Jiangsu, China.
FAU - Lv, Shan
AU  - Lv S
AD  - Department of Geriatric Endocrinology, The First Affiliated Hospital of Nanjing 
      Medical University, Nanjing 210029, Jiangsu, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20201121
PL  - United States
TA  - Aging (Albany NY)
JT  - Aging
JID - 101508617
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - Age Factors
MH  - Aging/metabolism/pathology
MH  - Animals
MH  - Body Composition
MH  - *Caloric Restriction
MH  - Humans
MH  - Mitochondria, Muscle/*metabolism/pathology
MH  - Muscle Strength
MH  - Muscle, Skeletal/*metabolism/pathology/physiopathology
MH  - Oxidative Stress
MH  - Reactive Oxygen Species/metabolism
MH  - Risk Factors
MH  - Sarcopenia/diagnosis/*diet therapy/metabolism/physiopathology
MH  - Sex Factors
MH  - Treatment Outcome
PMC - PMC7762489
OTO - NOTNLM
OT  - aging
OT  - calorie restriction
OT  - cellular mechanism
OT  - sarcopenia
COIS- CONFLICTS OF INTEREST: The authors declare that they have no conflicts of 
      interest.
EDAT- 2020/11/24 06:00
MHDA- 2021/04/28 06:00
PMCR- 2020/12/15
CRDT- 2020/11/23 17:09
PHST- 2020/05/22 00:00 [received]
PHST- 2020/08/14 00:00 [accepted]
PHST- 2020/11/24 06:00 [pubmed]
PHST- 2021/04/28 06:00 [medline]
PHST- 2020/11/23 17:09 [entrez]
PHST- 2020/12/15 00:00 [pmc-release]
AID - 103987 [pii]
AID - 10.18632/aging.103987 [doi]
PST - ppublish
SO  - Aging (Albany NY). 2020 Nov 21;12(23):24441-24452. doi: 10.18632/aging.103987. 
      Epub 2020 Nov 21.