PMID- 33227081
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201125
IS  - 0034-6233 (Print)
IS  - 2084-9834 (Electronic)
IS  - 0034-6233 (Linking)
VI  - 58
IP  - 5
DP  - 2020
TI  - The importance of homocysteine in the development of cardiovascular complications 
      in patients with rheumatoid arthritis.
PG  - 282-288
LID - 10.5114/reum.2020.99732 [doi]
AB  - Rheumatoid arthritis (RA) not only leads to disability due to joint changes, but 
      also significantly shortens the life expectancy of patients, mainly due to more 
      frequent occurrence of heart attacks and strokes. Accelerated atherosclerosis in 
      these patients is caused, among other factors, by high homocysteine (HCY) 
      concentration in blood. Numerous studies have shown that treatment with vitamin B 
      significantly reduces the concentration of HCY in blood, but does not reduce the 
      risk of heart diseases. Recent studies have shown, however, that folic acid (FA) 
      administration reduces the risk of stroke by 10-20%. Due to the fact that in 
      patients with RA strokes are more frequent than in the general population and 
      hyperhomocysteinemia (HHCY) is often found, determination of HCY concentration in 
      blood is advisable, and in persons with HHCY it is recommended to use FA in 
      primary and secondary stroke prevention.
CI  - Copyright: (c) 2020 Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w 
      Warszawie.
FAU - Gluszek, Jerzy
AU  - Gluszek J
AD  - The State Higher Vocational School in Kalisz, Poland.
FAU - Wierzowiecka, Malgorzata
AU  - Wierzowiecka M
AD  - Department of Hypertension, Angiology and Internal Medicine, Poznan University of 
      Medical Sciences, Poland.
FAU - Niklas, Karolina
AU  - Niklas K
AD  - Department of Rheumatology, Rehabilitation and Internal Medicine, Poznan 
      University of Medical Sciences, Poland.
FAU - Niklas, Arkadiusz
AU  - Niklas A
AD  - Department of Hypertension, Angiology and Internal Medicine, Poznan University of 
      Medical Sciences, Poland.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20201012
PL  - Poland
TA  - Reumatologia
JT  - Reumatologia
JID - 20130190R
PMC - PMC7667944
OTO - NOTNLM
OT  - folic acid
OT  - homocysteine
OT  - rheumatoid arthritis
OT  - stroke
COIS- The authors declare no conflict of interest.
EDAT- 2020/11/24 06:00
MHDA- 2020/11/24 06:01
PMCR- 2020/01/01
CRDT- 2020/11/23 17:10
PHST- 2020/07/20 00:00 [received]
PHST- 2020/09/16 00:00 [accepted]
PHST- 2020/11/23 17:10 [entrez]
PHST- 2020/11/24 06:00 [pubmed]
PHST- 2020/11/24 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 42008 [pii]
AID - 10.5114/reum.2020.99732 [doi]
PST - ppublish
SO  - Reumatologia. 2020;58(5):282-288. doi: 10.5114/reum.2020.99732. Epub 2020 Oct 12.