PMID- 33227284
OWN - NLM
STAT- MEDLINE
DCOM- 20210624
LR  - 20220310
IS  - 1873-3514 (Electronic)
IS  - 0028-3932 (Print)
IS  - 0028-3932 (Linking)
VI  - 150
DP  - 2021 Jan 8
TI  - Oscillatory correlates of auditory working memory examined with human 
      electrocorticography.
PG  - 107691
LID - S0028-3932(20)30363-8 [pii]
LID - 10.1016/j.neuropsychologia.2020.107691 [doi]
LID - 107691
AB  - This work examines how sounds are held in auditory working memory (AWM) in humans 
      by examining oscillatory local field potentials (LFPs) in candidate brain 
      regions. Previous fMRI studies by our group demonstrated blood oxygenation 
      level-dependent (BOLD) response increases during maintenance in auditory cortex, 
      inferior frontal cortex and the hippocampus using a paradigm with a delay period 
      greater than 10s. The relationship between such BOLD changes and ensemble 
      activity in different frequency bands is complex, and the long delay period 
      raised the possibility that long-term memory mechanisms were engaged. Here we 
      assessed LFPs in different frequency bands in six subjects with recordings from 
      all candidate brain regions using a paradigm with a short delay period of 3 s. 
      Sustained delay activity was demonstrated in all areas, with different patterns 
      in the different areas. Enhancement in low frequency (delta) power and 
      suppression across higher frequencies (beta/gamma) were demonstrated in primary 
      auditory cortex in medial Heschl's gyrus (HG) whilst non-primary cortex showed 
      patterns of enhancement and suppression that altered at different levels of the 
      auditory hierarchy from lateral HG to superior- and middle-temporal gyrus. 
      Inferior frontal cortex showed increasing suppression with increasing frequency. 
      The hippocampus and parahippocampal gyrus showed low frequency increases and high 
      frequency decreases in oscillatory activity. This work demonstrates sustained 
      activity patterns during AWM maintenance, with prominent low-frequency increases 
      in medial temporal lobe regions.
CI  - Copyright (c) 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Kumar, Sukhbinder
AU  - Kumar S
AD  - Newcastle University Medical School, Newcastle Upon Tyne, Tyne and Wear NE2 4HH, 
      UK. Electronic address: sukhbinder.kumar@ncl.ac.uk.
FAU - Gander, Phillip E
AU  - Gander PE
AD  - Department of Neurosurgery, The University of Iowa, Iowa City, IA, 52242, USA.
FAU - Berger, Joel I
AU  - Berger JI
AD  - Department of Neurosurgery, The University of Iowa, Iowa City, IA, 52242, USA.
FAU - Billig, Alexander J
AU  - Billig AJ
AD  - UCL Ear Institute, University College London, London, WC1X 8EE, UK.
FAU - Nourski, Kirill V
AU  - Nourski KV
AD  - Department of Neurosurgery, The University of Iowa, Iowa City, IA, 52242, USA; 
      Iowa Neuroscience Institute, The University of Iowa, Iowa City, IA, 52242, USA.
FAU - Oya, Hiroyuki
AU  - Oya H
AD  - Department of Neurosurgery, The University of Iowa, Iowa City, IA, 52242, USA.
FAU - Kawasaki, Hiroto
AU  - Kawasaki H
AD  - Department of Neurosurgery, The University of Iowa, Iowa City, IA, 52242, USA.
FAU - Howard, Matthew A 3rd
AU  - Howard MA 3rd
AD  - Department of Neurosurgery, The University of Iowa, Iowa City, IA, 52242, USA; 
      Iowa Neuroscience Institute, The University of Iowa, Iowa City, IA, 52242, USA; 
      Pappajohn Biomedical Institute, The University of Iowa, Iowa City, IA, 52242, 
      USA.
FAU - Griffiths, Timothy D
AU  - Griffiths TD
AD  - Newcastle University Medical School, Newcastle Upon Tyne, Tyne and Wear NE2 4HH, 
      UK; Department of Neurosurgery, The University of Iowa, Iowa City, IA, 52242, 
      USA; Wellcome Centre for Human Neuroimaging, University College London, London, 
      WC1N 3BG, UK.
LA  - eng
GR  - S10 OD025025/OD/NIH HHS/United States
GR  - WT106964MA/WT_/Wellcome Trust/United Kingdom
GR  - MR/T032553/1/MRC_/Medical Research Council/United Kingdom
GR  - WT_/Wellcome Trust/United Kingdom
GR  - R01 DC004290/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20201121
PL  - England
TA  - Neuropsychologia
JT  - Neuropsychologia
JID - 0020713
SB  - IM
EIN - Neuropsychologia. 2021 Aug 20;159:107950. PMID: 34246979
MH  - Acoustic Stimulation
MH  - *Auditory Cortex
MH  - Brain Mapping
MH  - *Electrocorticography
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Memory, Short-Term
MH  - Temporal Lobe
PMC - PMC7884909
OTO - NOTNLM
OT  - Auditory working memory
OT  - Electrocorticography
OT  - Hippocampus
OT  - Neurophysiology
OT  - Oscillatory activity
COIS- None
EDAT- 2020/11/24 06:00
MHDA- 2021/06/25 06:00
PMCR- 2021/01/08
CRDT- 2020/11/23 20:09
PHST- 2020/06/19 00:00 [received]
PHST- 2020/10/23 00:00 [revised]
PHST- 2020/11/16 00:00 [accepted]
PHST- 2020/11/24 06:00 [pubmed]
PHST- 2021/06/25 06:00 [medline]
PHST- 2020/11/23 20:09 [entrez]
PHST- 2021/01/08 00:00 [pmc-release]
AID - S0028-3932(20)30363-8 [pii]
AID - 107691 [pii]
AID - 10.1016/j.neuropsychologia.2020.107691 [doi]
PST - ppublish
SO  - Neuropsychologia. 2021 Jan 8;150:107691. doi: 
      10.1016/j.neuropsychologia.2020.107691. Epub 2020 Nov 21.