PMID- 33227505
OWN - NLM
STAT- MEDLINE
DCOM- 20211021
LR  - 20211021
IS  - 1095-9564 (Electronic)
IS  - 1074-7427 (Linking)
VI  - 177
DP  - 2021 Jan
TI  - Age-related alterations of default mode network in autobiographical memory: 
      Recent versus remote events.
PG  - 107341
LID - S1074-7427(20)30185-4 [pii]
LID - 10.1016/j.nlm.2020.107341 [doi]
AB  - Previous studies have shown that the vividness of autobiographical memory 
      decreases over time, and older adults often retrieve fewer details than young 
      adults. However, the age-by-temporal distance (i.e., recent versus remote events) 
      effect on autobiographical memory and underlying neural mechanisms are less 
      understood. We recruited 25 young adults and 27 older adults to perform an 
      fMRI-adapted autobiographical memory task with different temporal distances. The 
      results showed that older adults' vividness ratings were generally higher than 
      that of young adults, but were less sensitive to temporal distances. For neural 
      imaging, an age-by-temporal distance effect was found in the left precuneus, 
      manifested as young adults had more activation for recent events than for remote 
      events, whereas no temporal distance effect was found in older adults. 
      Interestingly, for older adults, the temporal distance effect was reflected by 
      functional connectivity within the default mode network (DMN), with a stronger 
      anterior DMN-posterior DMN coupling for remote events than for recent events, 
      whereas no temporal distance difference on functional connectivity was found in 
      young adults. The results suggest that older adults exhibit age-related neural 
      differences in both activation and functional connectivity during the processing 
      of autobiographical memory with different temporal distances, shedding new light 
      for the understanding of the relationship between the DMN, autobiographical 
      memory, and aging.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Xu, Hong-Zhou
AU  - Xu HZ
AD  - Faculty of Psychology, Southwest University, Chongqing, China.
FAU - Xu, Xiao-Xiao
AU  - Xu XX
AD  - Faculty of Psychology, Southwest University, Chongqing, China.
FAU - Lei, Xu
AU  - Lei X
AD  - Faculty of Psychology, Southwest University, Chongqing, China.
FAU - Yu, Jing
AU  - Yu J
AD  - Faculty of Psychology, Southwest University, Chongqing, China; Key Laboratory of 
      Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, 
      China. Electronic address: helen12@swu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201121
PL  - United States
TA  - Neurobiol Learn Mem
JT  - Neurobiology of learning and memory
JID - 9508166
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Brain/diagnostic imaging/physiology
MH  - *Default Mode Network/physiology
MH  - Functional Neuroimaging
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - *Memory, Episodic
MH  - Middle Aged
MH  - Time Factors
MH  - Young Adult
OTO - NOTNLM
OT  - Aging
OT  - Autobiographical memory
OT  - Default mode network
OT  - Functional connectivity
OT  - Temporal distance
EDAT- 2020/11/24 06:00
MHDA- 2023/02/25 06:00
CRDT- 2020/11/23 20:10
PHST- 2020/07/10 00:00 [received]
PHST- 2020/10/10 00:00 [revised]
PHST- 2020/11/15 00:00 [accepted]
PHST- 2020/11/24 06:00 [pubmed]
PHST- 2023/02/25 06:00 [medline]
PHST- 2020/11/23 20:10 [entrez]
AID - S1074-7427(20)30185-4 [pii]
AID - 10.1016/j.nlm.2020.107341 [doi]
PST - ppublish
SO  - Neurobiol Learn Mem. 2021 Jan;177:107341. doi: 10.1016/j.nlm.2020.107341. Epub 
      2020 Nov 21.