PMID- 33228010
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201226
IS  - 2309-608X (Electronic)
IS  - 2309-608X (Linking)
VI  - 6
IP  - 4
DP  - 2020 Nov 19
TI  - Overview of Antifungal Drugs against Paracoccidioidomycosis: How Do We Start, 
      Where Are We, and Where Are We Going?
LID - 10.3390/jof6040300 [doi]
LID - 300
AB  - Paracoccidioidomycosis is a neglected disease that causes economic and social 
      impacts, mainly affecting people of certain social segments, such as rural 
      workers. The limitations of antifungals, such as toxicity, drug interactions, 
      restricted routes of administration, and the reduced bioavailability in target 
      tissues, have become evident in clinical settings. These factors, added to the 
      fact that Paracoccidioidomycosis (PCM) therapy is a long process, lasting from 
      months to years, emphasize the need for the research and development of new 
      molecules. Researchers have concentrated efforts on the identification of new 
      compounds using numerous tools and targeting important proteins from 
      Paracoccidioides, with the emphasis on enzymatic pathways absent in humans. This 
      review aims to discuss the aspects related to the identification of compounds, 
      methodologies, and perspectives when proposing new antifungal agents against PCM.
FAU - do Carmo Silva, Livia
AU  - do Carmo Silva L
AD  - Laboratory of Molecular Biology, Institute of Biological Sciences, Federal 
      University of Goias, Goiania 74690-900, GO, Brazil.
AD  - Institute of Tropical Pathology and Public Health, Federal University of Goias, 
      Goiania 74605-050, GO, Brazil.
FAU - de Oliveira, Amanda Alves
AU  - de Oliveira AA
AD  - Laboratory of Molecular Biology, Institute of Biological Sciences, Federal 
      University of Goias, Goiania 74690-900, GO, Brazil.
AD  - Institute of Tropical Pathology and Public Health, Federal University of Goias, 
      Goiania 74605-050, GO, Brazil.
FAU - de Souza, Dienny Rodrigues
AU  - de Souza DR
AUID- ORCID: 0000-0003-1683-1514
AD  - Laboratory of Molecular Biology, Institute of Biological Sciences, Federal 
      University of Goias, Goiania 74690-900, GO, Brazil.
AD  - Institute of Tropical Pathology and Public Health, Federal University of Goias, 
      Goiania 74605-050, GO, Brazil.
FAU - Barbosa, Katheryne Lohany Barros
AU  - Barbosa KLB
AD  - Laboratory of Molecular Biology, Institute of Biological Sciences, Federal 
      University of Goias, Goiania 74690-900, GO, Brazil.
AD  - Institute of Tropical Pathology and Public Health, Federal University of Goias, 
      Goiania 74605-050, GO, Brazil.
FAU - Freitas E Silva, Kleber Santiago
AU  - Freitas E Silva KS
AUID- ORCID: 0000-0001-5350-7313
AD  - Laboratory of Molecular Biology, Institute of Biological Sciences, Federal 
      University of Goias, Goiania 74690-900, GO, Brazil.
FAU - Carvalho Junior, Marcos Antonio Batista
AU  - Carvalho Junior MAB
AUID- ORCID: 0000-0003-1513-3247
AD  - Laboratory of Molecular Biology, Institute of Biological Sciences, Federal 
      University of Goias, Goiania 74690-900, GO, Brazil.
FAU - Rocha, Olivia Basso
AU  - Rocha OB
AUID- ORCID: 0000-0002-2094-6042
AD  - Laboratory of Molecular Biology, Institute of Biological Sciences, Federal 
      University of Goias, Goiania 74690-900, GO, Brazil.
FAU - Lima, Raisa Melo
AU  - Lima RM
AUID- ORCID: 0000-0003-1210-8302
AD  - Laboratory of Molecular Biology, Institute of Biological Sciences, Federal 
      University of Goias, Goiania 74690-900, GO, Brazil.
AD  - Institute of Tropical Pathology and Public Health, Federal University of Goias, 
      Goiania 74605-050, GO, Brazil.
FAU - Santos, Thaynara Gonzaga
AU  - Santos TG
AD  - Laboratory of Molecular Biology, Institute of Biological Sciences, Federal 
      University of Goias, Goiania 74690-900, GO, Brazil.
AD  - Institute of Tropical Pathology and Public Health, Federal University of Goias, 
      Goiania 74605-050, GO, Brazil.
FAU - Soares, Celia Maria de Almeida
AU  - Soares CMA
AUID- ORCID: 0000-0001-5378-9840
AD  - Laboratory of Molecular Biology, Institute of Biological Sciences, Federal 
      University of Goias, Goiania 74690-900, GO, Brazil.
FAU - Pereira, Maristela
AU  - Pereira M
AD  - Laboratory of Molecular Biology, Institute of Biological Sciences, Federal 
      University of Goias, Goiania 74690-900, GO, Brazil.
LA  - eng
GR  - 001/Conselho Nacional de Desenvolvimento Cientifico e Tecnologico/
GR  - 001/Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior/
PT  - Journal Article
PT  - Review
DEP - 20201119
PL  - Switzerland
TA  - J Fungi (Basel)
JT  - Journal of fungi (Basel, Switzerland)
JID - 101671827
PMC - PMC7712482
OTO - NOTNLM
OT  - Paracoccidioidomycosis
OT  - antifungal
OT  - nanotechnology
OT  - patent
COIS- The authors declare no conflict of interest.
EDAT- 2020/11/25 06:00
MHDA- 2020/11/25 06:01
PMCR- 2020/11/19
CRDT- 2020/11/24 01:06
PHST- 2020/09/23 00:00 [received]
PHST- 2020/11/13 00:00 [revised]
PHST- 2020/11/16 00:00 [accepted]
PHST- 2020/11/24 01:06 [entrez]
PHST- 2020/11/25 06:00 [pubmed]
PHST- 2020/11/25 06:01 [medline]
PHST- 2020/11/19 00:00 [pmc-release]
AID - jof6040300 [pii]
AID - jof-06-00300 [pii]
AID - 10.3390/jof6040300 [doi]
PST - epublish
SO  - J Fungi (Basel). 2020 Nov 19;6(4):300. doi: 10.3390/jof6040300.