PMID- 33229676
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20220418
IS  - 1998-3689 (Electronic)
IS  - 0301-4738 (Print)
IS  - 0301-4738 (Linking)
VI  - 68
IP  - 12
DP  - 2020 Dec
TI  - Photorefractive keratectomy (PRK) Prediction, Examination, tReatment, Follow-up, 
      Evaluation, Chronic Treatment (PERFECT) protocol - A new algorithmic approach for 
      managing post PRK haze.
PG  - 2950-2955
LID - 10.4103/ijo.IJO_2623_20 [doi]
AB  - PURPOSE: The aim of this study was to discuss the possible risk factors 
      predisposing to post photorefractive keratectomy (PRK) haze formation and develop 
      and validate a risk scoring system, so that this could be applied to our clinical 
      practice as an algorithmic approach. METHODS: Study was divided into 2 arms, in 
      the retrospective arm we looked at 238 eyes of patients undergoing PRK where 
      certain presumed risk factors from literature and clinical experience were 
      identified and statistical significance of association was studied in the 
      development of corneal haze. The risk scoring system was applied to the 450 eyes 
      in the prospective arm for validation. This was then used to formulate an 
      algorithmic approach to manage post-PRK haze. RESULTS: 22 out of 238 eyes in the 
      retrospective arm developed haze where risk factors such as contact lens 
      intolerance, altered tear film break up time, meibomian gland drop out and 
      vitamin d levels were significantly associated with post-PRK haze (p < 0.05) and 
      these factors were identified in the prospective arm. Treatment of these 
      modifiable factors led to a significant reduction in post-PRK haze. CONCLUSION: 
      Thus identifying and treating risk factors of haze in patients undergoing PRK 
      could improve surgical outcomes and patient satisfaction.
FAU - Kundu, Gairik
AU  - Kundu G
AD  - Department of Cornea and Refractive Surgery, Narayana Nethralaya Eye Hospital, 
      Bengaluru, Karnataka, India.
FAU - D'Souza, Sharon
AU  - D'Souza S
AD  - Department of Cornea and Refractive Surgery, Narayana Nethralaya Eye Hospital, 
      Bengaluru, Karnataka, India.
FAU - Lalgudi, Vaitheeswaran Ganesan
AU  - Lalgudi VG
AD  - Department of Cornea and Refractive Surgery, Narayana Nethralaya Eye Hospital, 
      Bengaluru, Karnataka, India.
FAU - Arora, Vishal
AU  - Arora V
AD  - Aro Health, Gurugram, Haryana, India.
FAU - Chhabra, Aishwarya
AU  - Chhabra A
AD  - Department of Cornea and Refractive Surgery, Narayana Nethralaya Eye Hospital, 
      Bengaluru, Karnataka, India.
FAU - Deshpande, Kalyani
AU  - Deshpande K
AD  - Mumbai Eye, Brain and Spine Clinic, Mumbai, Maharashtra, India.
FAU - Shetty, Rohit
AU  - Shetty R
AD  - Department of Cornea and Refractive Surgery, Narayana Nethralaya Eye Hospital, 
      Bengaluru, Karnataka, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Ophthalmol
JT  - Indian journal of ophthalmology
JID - 0405376
SB  - IM
MH  - Cornea/surgery
MH  - Follow-Up Studies
MH  - Humans
MH  - Lasers, Excimer/therapeutic use
MH  - *Photorefractive Keratectomy
MH  - Prospective Studies
MH  - Retrospective Studies
PMC - PMC7857001
OTO - NOTNLM
OT  - Haze
OT  - PRK
OT  - management
OT  - prediction
OT  - risk
COIS- None
EDAT- 2020/11/25 06:00
MHDA- 2021/05/15 06:00
PMCR- 2020/12/01
CRDT- 2020/11/24 05:57
PHST- 2020/11/24 05:57 [entrez]
PHST- 2020/11/25 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2020/12/01 00:00 [pmc-release]
AID - IndianJOphthalmol_2020_68_12_2950_301258 [pii]
AID - IJO-68-2950 [pii]
AID - 10.4103/ijo.IJO_2623_20 [doi]
PST - ppublish
SO  - Indian J Ophthalmol. 2020 Dec;68(12):2950-2955. doi: 10.4103/ijo.IJO_2623_20.