PMID- 33230624
OWN - NLM
STAT- MEDLINE
DCOM- 20210517
LR  - 20210517
IS  - 0942-0940 (Electronic)
IS  - 0001-6268 (Linking)
VI  - 163
IP  - 1
DP  - 2021 Jan
TI  - Morbidity and mortality following degenerative spine surgery in a prospective 
      cohort of 1687 consecutive surgical procedures.
PG  - 281-287
LID - 10.1007/s00701-020-04655-5 [doi]
AB  - STUDY DESIGN: Prospective, observational cohort study. OBJECTIVE: To determine 
      the true incidence of adverse events (AEs) in European adults undergoing surgery 
      for degenerative spine diseases. The majority of surgeries performed for 
      degenerative spinal diseases are elective, and the need for adequate estimation 
      of risk-benefit of the intended surgery is imperative. A cumbersome obstacle for 
      adequate estimation of surgery-related risks is that the true incidence of 
      complications or adverse events (AEs) remains unclear. METHODS: All adult 
      patients (>/= 18 years) undergoing spine surgery at a single center from February 
      1, 2016, to January 31, 2017, were prospectively and consecutively included. 
      Morbidity and mortality were determined using the Spine AdVerse Events Severity 
      (SAVES) system. Additionally, the correlation between the AEs and length of stay 
      (LOS) and mortality was assessed. RESULTS: A total of 1687 procedures were 
      performed in the study period, and all were included for analysis. Of these, 1399 
      (83%) were lumbar procedures and 288 (17%) were cervical. The overall incidence 
      of AEs was 47.4%, with a minor AE incidence of 43.2% and a major of 14.5%. Female 
      sex (OR 1.5 [95% CI 1.2-1.9), p < 0.001) and age > 65 years (OR 1.5 [95% CI 
      1.1-1.7], p = 0.012) were significantly associated with increased odds of having 
      an AE. CONCLUSION: Based on prospectively registered AEs in this single-center 
      study, we validated the use of the SAVES system in a European population 
      undergoing spine surgery due to degenerative spine disease. We found a higher 
      incidence of AEs than previously reported in retrospective studies. The major AEs 
      registered occurred significantly more often perioperatively and in patients > 65 
      years.
FAU - Solumsmoen, Stian
AU  - Solumsmoen S
AUID- ORCID: 0000-0002-0364-3437
AD  - Copenhagen Spine Research Unit (CSRU), Section of Spine Surgery, Center of 
      Rheumatology and Spine Diseases, Rigshospitalet-Glostrup, Valdemar Hansens vej 
      17, 2600, Glostrup, Denmark. stian.iversen.solumsmoen@regionh.dk.
AD  - Department of Epidemiology Research, Statens Serum Institut, 2300, Copenhagen, 
      Artillerivej 5, Denmark. stian.iversen.solumsmoen@regionh.dk.
FAU - Bari, Tanvir Johanning
AU  - Bari TJ
AD  - Spine Unit, Department of Orthopedic Surgery, Rigshospitalet, Copenhagen 
      University Hospital, Blegdamsvej 9, 2100, Copenhagen, Denmark.
FAU - Woldu, Sara
AU  - Woldu S
AD  - Copenhagen Spine Research Unit (CSRU), Section of Spine Surgery, Center of 
      Rheumatology and Spine Diseases, Rigshospitalet-Glostrup, Valdemar Hansens vej 
      17, 2600, Glostrup, Denmark.
FAU - Zielinski, Oliver Bremerskov
AU  - Zielinski OB
AD  - Copenhagen Spine Research Unit (CSRU), Section of Spine Surgery, Center of 
      Rheumatology and Spine Diseases, Rigshospitalet-Glostrup, Valdemar Hansens vej 
      17, 2600, Glostrup, Denmark.
FAU - Gehrchen, Martin
AU  - Gehrchen M
AD  - Spine Unit, Department of Orthopedic Surgery, Rigshospitalet, Copenhagen 
      University Hospital, Blegdamsvej 9, 2100, Copenhagen, Denmark.
AD  - Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
FAU - Dahl, Benny
AU  - Dahl B
AD  - Department of Orthopedics and Scoliosis Surgery, Texas Children's Hospital and 
      Baylor College of Medicine, 6621 Fannin St, Houston, TX, 77030, USA.
FAU - Bech-Azeddine, Rachid
AU  - Bech-Azeddine R
AD  - Copenhagen Spine Research Unit (CSRU), Section of Spine Surgery, Center of 
      Rheumatology and Spine Diseases, Rigshospitalet-Glostrup, Valdemar Hansens vej 
      17, 2600, Glostrup, Denmark.
AD  - Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20201123
PL  - Austria
TA  - Acta Neurochir (Wien)
JT  - Acta neurochirurgica
JID - 0151000
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cohort Studies
MH  - Elective Surgical Procedures/*adverse effects
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Length of Stay/statistics & numerical data
MH  - Male
MH  - Middle Aged
MH  - Postoperative Complications/*epidemiology
MH  - Spine/*surgery
OTO - NOTNLM
OT  - Adverse events
OT  - Complications
OT  - Degenerative spine surgery
OT  - Prospective
EDAT- 2020/11/25 06:00
MHDA- 2021/05/18 06:00
CRDT- 2020/11/24 06:06
PHST- 2020/09/14 00:00 [received]
PHST- 2020/11/16 00:00 [accepted]
PHST- 2020/11/25 06:00 [pubmed]
PHST- 2021/05/18 06:00 [medline]
PHST- 2020/11/24 06:06 [entrez]
AID - 10.1007/s00701-020-04655-5 [pii]
AID - 10.1007/s00701-020-04655-5 [doi]
PST - ppublish
SO  - Acta Neurochir (Wien). 2021 Jan;163(1):281-287. doi: 10.1007/s00701-020-04655-5. 
      Epub 2020 Nov 23.