PMID- 33232678
OWN - NLM
STAT- MEDLINE
DCOM- 20211115
LR  - 20211115
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 399
DP  - 2021 Feb 5
TI  - Effects of water restriction on social behavior and 5-HT neurons density in the 
      dorsal and median raphe nuclei in mice.
PG  - 113022
LID - S0166-4328(20)30721-X [pii]
LID - 10.1016/j.bbr.2020.113022 [doi]
AB  - We explored here the hypothesis that temporary chronic water restriction in mice 
      affects social behavior, via its action on the density of 5-HT neurons in dorsal 
      and median raphe nuclei (DRN and MRN). For that, we submitted adult C57BL/6 J 
      mice to mild and controlled temporary dehydration, i.e., 6 h of water access 
      every 48 h for 15 days. We investigated their social behavior in a social 
      interaction task known to allow free and reciprocal social contact. Results 
      showed that temporary dehydration increases significantly time spent in social 
      contact and social dominance. It also expands 5-HT neuron density within both DRN 
      and MRN and the behavioral and neuronal plasticity were positively correlated. 
      Our findings suggest that disturbance in 5-HT neurotransmission caused by 
      temporary dehydration stress unbalances choice processes of animals in social 
      context.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Boukersi, Houari
AU  - Boukersi H
AD  - Department of Biology, Faculty of Natural Science and Life, Hassiba Benbouali 
      University, Chlef, Algeria; Animal Ecophysiology Laboratory, Higher Normal School 
      Elbachir El-Ibrahimi, Kouba, Algers, Algeria; Paris-Saclay Institute of 
      Neuroscience (NeuroPSI), Paris-Saclay University, CNRS 9197, Orsay, France. 
      Electronic address: h.boukersi@univ-chlef.dz.
FAU - Lebaili, Nemcha
AU  - Lebaili N
AD  - Animal Ecophysiology Laboratory, Higher Normal School Elbachir El-Ibrahimi, 
      Kouba, Algers, Algeria.
FAU - Nosjean, Anne
AU  - Nosjean A
AD  - Paris-Saclay Institute of Neuroscience (NeuroPSI), Paris-Saclay University, CNRS 
      9197, Orsay, France.
FAU - Samson, Nathalie
AU  - Samson N
AD  - Paris-Saclay Institute of Neuroscience (NeuroPSI), Paris-Saclay University, CNRS 
      9197, Orsay, France.
FAU - Faure, Alexis
AU  - Faure A
AD  - Paris-Saclay Institute of Neuroscience (NeuroPSI), Paris-Saclay University, CNRS 
      9197, Orsay, France.
FAU - Granon, Sylvie
AU  - Granon S
AD  - Paris-Saclay Institute of Neuroscience (NeuroPSI), Paris-Saclay University, CNRS 
      9197, Orsay, France.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201121
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 333DO1RDJY (Serotonin)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*physiology
MH  - Cell Count
MH  - *Dehydration/complications/metabolism
MH  - Disease Models, Animal
MH  - Dorsal Raphe Nucleus/cytology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Raphe Nuclei/*cytology
MH  - Serotonergic Neurons/*cytology
MH  - Serotonin/*metabolism
MH  - *Social Behavior
MH  - Social Dominance
OTO - NOTNLM
OT  - Dehydration
OT  - Immunohistochemistry
OT  - Raphe nucleus
OT  - Serotonin
OT  - Social behavior
EDAT- 2020/11/25 06:00
MHDA- 2021/11/16 06:00
CRDT- 2020/11/24 20:07
PHST- 2020/06/16 00:00 [received]
PHST- 2020/11/12 00:00 [revised]
PHST- 2020/11/13 00:00 [accepted]
PHST- 2020/11/25 06:00 [pubmed]
PHST- 2021/11/16 06:00 [medline]
PHST- 2020/11/24 20:07 [entrez]
AID - S0166-4328(20)30721-X [pii]
AID - 10.1016/j.bbr.2020.113022 [doi]
PST - ppublish
SO  - Behav Brain Res. 2021 Feb 5;399:113022. doi: 10.1016/j.bbr.2020.113022. Epub 2020 
      Nov 21.