PMID- 33233073
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 1873-7145 (Electronic)
IS  - 0963-9969 (Linking)
VI  - 137
DP  - 2020 Nov
TI  - Comprehensive bioactivity and chemical characterization of the endemic plant 
      Scorzonera hieraciifolia Hayek extracts: A promising source of bioactive 
      compounds.
PG  - 109371
LID - S0963-9969(20)30396-3 [pii]
LID - 10.1016/j.foodres.2020.109371 [doi]
AB  - Members of Scorzonera genus are known for their potential application in both 
      food and pharmaceutical industries. The present study reports the chemical 
      component and bioactivity of the dichloromethane, ethyl acetate, hexane, methanol 
      and infused extracts of Scorzonera hieraciifolia Hayek aerial parts and roots. 
      The methanolic extracts of both aerial parts and roots were good sources of total 
      phenolic and flavonoid content. For the aerial parts, the infused and methanolic 
      extracts showed highest (p < 0.05) free radical scavenging 
      (2,2-diphenyl-1-picrylhydrazyl (DPPH) and 
      2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS)), reducing (cupric 
      reducing antioxidant capacity (CUPRAC))and ferric reducing antioxidant power 
      (FRAP)) and metal chelating capacities. Whilst, for the root extracts, overall 
      most remarkable free scavenging and reducing activity was observed for the 
      methanolic extracts (p < 0.05) while the hexane extracts showed highest metal 
      chelating activity. The inhibitory activity of the extracts was evaluated against 
      key enzymes. Overall, the hexane extracts of both aerial parts 
      (acetylcholinesterase (AChE): 2.27 +/- 0.04 and butyrlcholinesterase (BChE): 
      5.75 +/- 0.48 mg galantamine equivalent (GALAE)/g) and roots (AChE: 2.44 +/- 0.35 and 
      BChE: 53.17 +/- 0.22 mg GALAE/g) were most potent against AChE and BChE, suggesting 
      a role for the more lipophilic compounds in this regard. The highest inhibitory 
      activity against tyrosinase was displayed by methanolic extracts of aerial parts 
      (64.70 +/- 0.26 mg kojic acid equivalent (KAE)/g) and roots (63.63 +/- 0.20 mg 
      KAE/g). Modest activity was observed against alpha-amylase and alpha-glucosidase, two 
      major enzymes implicated in the pathology of diabetes. Liquid chromatography-mass 
      spectrometry (LC-MS) and nuclear magnetic resonance (NMR) analysis showed the 
      presence of 40 compounds such as caffeic, ursolic, betulinic and oleanolic acid 
      and their derivatives in the studied extracts. Multivariate analysis showed that 
      the biological activities were dependent on the plant parts used as well as on 
      the type of solvent used. Overall, the results showed that S. hieraciifolia is a 
      valuable source of phytochemicals for both the nutraceutical and pharmaceutical 
      sectors.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Dall'Acqua, Stefano
AU  - Dall'Acqua S
AD  - Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 
      Via Marzolo 5, 35131 Padova, Italy.
FAU - Ak, Gunes
AU  - Ak G
AD  - Department of Biology, Science Faculty, Selcuk University, Campus, 42130 Konya, 
      Turkey.
FAU - Sut, Stefania
AU  - Sut S
AD  - DAFNAE, Department of Agronomy, Food, Natural Resources, Animals and Environment, 
      Agripolis Campus, University of Padova, 35020 Legnaro (PD), Italy.
FAU - Zengin, Gokhan
AU  - Zengin G
AD  - Department of Biology, Science Faculty, Selcuk University, Campus, 42130 Konya, 
      Turkey. Electronic address: gokhanzengin@selcuk.edu.tr.
FAU - Yildiztugay, Evren
AU  - Yildiztugay E
AD  - Department of Biotechnology, Science Faculty, Selcuk University, Campus, 42130 
      Konya, Turkey.
FAU - Fawzi Mahomoodally, Mohamad
AU  - Fawzi Mahomoodally M
AD  - Institute of Research and Development, Duy Tan University, Da Nang 550000, Viet 
      Nam; Department of Health Sciences, Faculty of Science, University of Mauritius, 
      230 Reduit, Mauritius.
FAU - Ibrahime Sinan, Kouadio
AU  - Ibrahime Sinan K
AD  - Department of Biology, Science Faculty, Selcuk University, Campus, 42130 Konya, 
      Turkey.
FAU - Lobine, Devina
AU  - Lobine D
AD  - Department of Health Sciences, Faculty of Science, University of Mauritius, 230 
      Reduit, Mauritius.
LA  - eng
PT  - Journal Article
DEP - 20200603
PL  - Canada
TA  - Food Res Int
JT  - Food research international (Ottawa, Ont.)
JID - 9210143
RN  - 0 (Antioxidants)
RN  - 0 (Flavonoids)
RN  - 0 (Phytochemicals)
RN  - 0 (Plant Extracts)
SB  - IM
MH  - Antioxidants/pharmacology
MH  - Flavonoids
MH  - Phytochemicals
MH  - *Plant Extracts/pharmacology
MH  - *Scorzonera
OTO - NOTNLM
OT  - Antioxidant
OT  - Biopharmaceutical
OT  - Diabetes
OT  - Medicinal plants
OT  - Multivariate
EDAT- 2020/11/26 06:00
MHDA- 2021/05/15 06:00
CRDT- 2020/11/25 01:01
PHST- 2020/03/15 00:00 [received]
PHST- 2020/05/24 00:00 [revised]
PHST- 2020/05/30 00:00 [accepted]
PHST- 2020/11/25 01:01 [entrez]
PHST- 2020/11/26 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
AID - S0963-9969(20)30396-3 [pii]
AID - 10.1016/j.foodres.2020.109371 [doi]
PST - ppublish
SO  - Food Res Int. 2020 Nov;137:109371. doi: 10.1016/j.foodres.2020.109371. Epub 2020 
      Jun 3.