PMID- 33233343
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201201
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 9
IP  - 11
DP  - 2020 Nov 21
TI  - Determining the Minimal Clinical Important Difference for Medication 
      Quantification Scale III and Morphine Milligram Equivalents in Patients with 
      Failed Back Surgery Syndrome.
LID - 10.3390/jcm9113747 [doi]
LID - 3747
AB  - The Medication Quantification Scale III (MQS) is a tool to represent the negative 
      impact of medication. A reduction in medication can serve as an indicator to 
      evaluate treatment success. However, no cut-off value has yet been determined to 
      evaluate whether a decrease in medication is clinically relevant. Therefore, the 
      objective is to estimate the thresholds for the MQS and morphine milligram 
      equivalents (MMEs) that best identify a clinically relevant important improvement 
      for patients. Data from the Discover registry, in which patients with failed back 
      surgery syndrome were treated with high-dose spinal cord stimulation, were used. 
      Patient satisfaction was utilized to evaluate a clinically important outcome 12 
      months after stimulation. Anchor-based and distribution-based methods were 
      applied to determine the minimal clinical important difference (MCID). 
      Distribution-based methods revealed a value of 4.28 for the MQS and 33.61 for the 
      MME as MCID. Anchor-based methods indicated a percentage change score of 41.2% 
      for the MQS and 28.2% for the MME or an absolute change score of 4.72 for the MQS 
      and 22.65 for the MME. For assessing a treatment outcome, we recommend using the 
      percentage change score, which better reflects a clinically important outcome and 
      is not severely influenced by high medication intake at baseline.
FAU - Goudman, Lisa
AU  - Goudman L
AUID- ORCID: 0000-0002-2271-9855
AD  - Department of Neurosurgery, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 
      1090 Jette, Belgium.
AD  - Center for Neurosciences (C4N), Vrije Universiteit Brussel, Laarbeeklaan 103, 
      1090 Jette, Belgium.
AD  - STIMULUS Consortium (reSearch and TeachIng neuroModULation Uz bruSsel), 
      Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium.
AD  - Pain in Motion International Research Group (PAIN), Vrije Universiteit Brussel, 
      Laarbeeklaan 103, 1090 Jette, Belgium.
FAU - Smedt, Ann De
AU  - Smedt A
AD  - Center for Neurosciences (C4N), Vrije Universiteit Brussel, Laarbeeklaan 103, 
      1090 Jette, Belgium.
AD  - STIMULUS Consortium (reSearch and TeachIng neuroModULation Uz bruSsel), 
      Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium.
AD  - Department of Physical Medicine and Rehabilitation, Universitair Ziekenhuis 
      Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium.
FAU - Forget, Patrice
AU  - Forget P
AUID- ORCID: 0000-0001-5772-8439
AD  - Institute of Applied Health Sciences, NHS Grampian, University of Aberdeen, 
      Aberdeen AB25 2ZD, UK.
FAU - Moens, Maarten
AU  - Moens M
AUID- ORCID: 0000-0003-0577-5449
AD  - Department of Neurosurgery, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 
      1090 Jette, Belgium.
AD  - Center for Neurosciences (C4N), Vrije Universiteit Brussel, Laarbeeklaan 103, 
      1090 Jette, Belgium.
AD  - STIMULUS Consortium (reSearch and TeachIng neuroModULation Uz bruSsel), 
      Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium.
AD  - Department of Radiology, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 1090 
      Jette, Belgium.
LA  - eng
GR  - independent research grant/Medtronic Europe Sarl/
PT  - Journal Article
DEP - 20201121
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC7700681
OTO - NOTNLM
OT  - clinical importance
OT  - minimal clinically important difference
OT  - responsiveness
COIS- Patrice Forget has been an advisory board member for Grunenthal. Maarten Moens 
      has received speaker fees from Medtronic and Nevro. There are no other conflicts 
      of interests to declare.
EDAT- 2020/11/26 06:00
MHDA- 2020/11/26 06:01
PMCR- 2020/11/21
CRDT- 2020/11/25 01:03
PHST- 2020/10/06 00:00 [received]
PHST- 2020/11/14 00:00 [revised]
PHST- 2020/11/20 00:00 [accepted]
PHST- 2020/11/25 01:03 [entrez]
PHST- 2020/11/26 06:00 [pubmed]
PHST- 2020/11/26 06:01 [medline]
PHST- 2020/11/21 00:00 [pmc-release]
AID - jcm9113747 [pii]
AID - jcm-09-03747 [pii]
AID - 10.3390/jcm9113747 [doi]
PST - epublish
SO  - J Clin Med. 2020 Nov 21;9(11):3747. doi: 10.3390/jcm9113747.