PMID- 33234769
OWN - NLM
STAT- MEDLINE
DCOM- 20211110
LR  - 20211110
IS  - 2233-6869 (Electronic)
IS  - 1598-9992 (Linking)
VI  - 76
IP  - 5
DP  - 2020 Nov 25
TI  - [Prevention of Non-steroidal Anti-inflammatory Drug-induced Peptic Ulcers].
PG  - 232-237
LID - 10.4166/kjg.2020.139 [doi]
AB  - Nonsteroidal anti-inflammatory drugs (NSAID) are some of the most commonly 
      prescribed medications in clinical practice. The long-term use of NSAIDs is one 
      of the main causes of peptic ulcers and the increased risk of upper 
      gastrointestinal tract complications, such as perforation and bleeding. Thus, the 
      prevention of NSAID-induced peptic ulcers is an important clinical issue. 
      Previous studies have evaluated various strategies for preventing ulcers in 
      patients requiring prolonged NSAID use. The Korean clinical practice guidelines 
      have been published recently based on the evidence of the currently available 
      data. This review describes the strategies for the prevention of peptic ulcers 
      due to NSAID. An assessment of the risk factors for peptic ulcers from NSAID is 
      recommended to identify patients who should be considered for primary 
      prophylaxis. The risk of NSAID-induced peptic ulcers can be reduced by the 
      concomitant use of proton pump inhibitors (PPI), misoprostol, and histamine-2 
      receptor antagonists. Selective cyclooxygenase-2 inhibitors can be used with 
      caution due to concerns regarding cardiovascular toxicity. Attempts should be 
      made to use the lowest dose and shortest duration of the NSAID.
FAU - Chu, Seong Jun
AU  - Chu SJ
AD  - Division of Gastroenterology, Department of Internal Medicine, Incheon St. Mary's 
      Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
FAU - Yoon, Kyu-Tae
AU  - Yoon KT
AD  - Division of Gastroenterology, Department of Internal Medicine, Incheon St. Mary's 
      Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
FAU - Kim, Joon Sung
AU  - Kim JS
AUID- ORCID: 0000-0001-9158-1012
AD  - Division of Gastroenterology, Department of Internal Medicine, Incheon St. Mary's 
      Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
LA  - kor
PT  - Journal Article
PT  - Review
PL  - Korea (South)
TA  - Korean J Gastroenterol
JT  - The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
JID - 101189416
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Anti-Ulcer Agents)
RN  - 0 (Histamine H2 Antagonists)
RN  - 0 (Pharmaceutical Preparations)
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Anti-Inflammatory Agents, Non-Steroidal/adverse effects
MH  - Anti-Ulcer Agents/therapeutic use
MH  - Histamine H2 Antagonists/therapeutic use
MH  - Humans
MH  - *Peptic Ulcer/chemically induced/drug therapy/prevention & control
MH  - Pharmaceutical Preparations
MH  - Proton Pump Inhibitors/therapeutic use
MH  - Risk Factors
OTO - NOTNLM
OT  - Anti-inflammatory agents
OT  - Peptic ulcer
OT  - Primary prevention
OT  - non-steroidal
EDAT- 2020/11/26 06:00
MHDA- 2021/11/11 06:00
CRDT- 2020/11/25 05:38
PHST- 2020/10/07 00:00 [received]
PHST- 2020/10/21 00:00 [revised]
PHST- 2020/10/24 00:00 [accepted]
PHST- 2020/11/25 05:38 [entrez]
PHST- 2020/11/26 06:00 [pubmed]
PHST- 2021/11/11 06:00 [medline]
AID - kjg.2020.139 [pii]
AID - 10.4166/kjg.2020.139 [doi]
PST - ppublish
SO  - Korean J Gastroenterol. 2020 Nov 25;76(5):232-237. doi: 10.4166/kjg.2020.139.