PMID- 33236643
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240216
IS  - 1535-7597 (Print)
IS  - 1535-7511 (Electronic)
IS  - 1535-7511 (Linking)
VI  - 21
IP  - 1
DP  - 2021 Jan-Feb
TI  - The Role of the Persistent Sodium Current in Epilepsy.
PG  - 40-47
LID - 10.1177/1535759720973978 [doi]
AB  - Voltage-gated sodium channels (VGSCs) are foundational to excitable cell 
      function: Their coordinated passage of sodium ions into the cell is critical for 
      the generation and propagation of action potentials throughout the nervous 
      system. The classical paradigm of action potential physiology states that sodium 
      passes through the membrane only transiently (1-2 milliseconds), before the 
      channels inactivate and cease to conduct sodium ions. However, in reality, a 
      small fraction of the total sodium current (1%-2%) remains at steady state 
      despite prolonged depolarization. While this persistent sodium current (I(NaP)) 
      contributes to normal physiological functioning of neurons, accumulating evidence 
      indicates a particularly pathogenic role for an elevated I(NaP) in epilepsy 
      (reviewed previously(1)). Due to significant advances over the past decade of 
      epilepsy research concerning the importance of I(NaP) in sodium channelopathies, 
      this review seeks to summarize recent evidence and highlight promising novel 
      anti-seizure medication strategies through preferentially targeting I(NaP).
FAU - Wengert, Eric R
AU  - Wengert ER
AD  - Department of Anesthesiology, 12350University of Virginia Health System, 
      Charlottesville, VA, USA.
AD  - Neuroscience Graduate Program, 12350University of Virginia, Charlottesville, VA, 
      USA.
FAU - Patel, Manoj K
AU  - Patel MK
AUID- ORCID: 0000-0003-3591-6716
AD  - Department of Anesthesiology, 12350University of Virginia Health System, 
      Charlottesville, VA, USA.
AD  - Neuroscience Graduate Program, 12350University of Virginia, Charlottesville, VA, 
      USA.
LA  - eng
GR  - F31 NS115451/NS/NINDS NIH HHS/United States
GR  - R01 NS103090/NS/NINDS NIH HHS/United States
PT  - Journal Article
DEP - 20201125
PL  - United States
TA  - Epilepsy Curr
JT  - Epilepsy currents
JID - 101135954
PMC - PMC7863310
OTO - NOTNLM
OT  - anti-seizure medication
OT  - channelopathy
OT  - epilepsy
OT  - epileptic encephalopathy
OT  - persistent sodium current
OT  - voltage-gated sodium channels
COIS- Declaration of Conflicting Interests: The author(s) declared the following 
      potential conflicts of interest with respect to the research, authorship, and/or 
      publication of this article: The authors declare the following potential conflict 
      of interest with respect to the research, authorship, and/or publication of this 
      article. M.K.P. has received prior research funding from Praxis Precision 
      Medicines
EDAT- 2020/11/26 06:00
MHDA- 2020/11/26 06:01
PMCR- 2020/11/25
CRDT- 2020/11/25 08:36
PHST- 2020/11/26 06:00 [pubmed]
PHST- 2020/11/26 06:01 [medline]
PHST- 2020/11/25 08:36 [entrez]
PHST- 2020/11/25 00:00 [pmc-release]
AID - 10.1177_1535759720973978 [pii]
AID - 10.1177/1535759720973978 [doi]
PST - ppublish
SO  - Epilepsy Curr. 2021 Jan-Feb;21(1):40-47. doi: 10.1177/1535759720973978. Epub 2020 
      Nov 25.