PMID- 33236731
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 2047-4849 (Electronic)
IS  - 2047-4830 (Linking)
VI  - 9
IP  - 3
DP  - 2021 Feb 9
TI  - Polarization behavior of bone marrow-derived macrophages on charged P(VDF-TrFE) 
      coatings.
PG  - 874-881
LID - 10.1039/d0bm01604g [doi]
AB  - The immune response of bone implants is closely related to the interaction 
      between macrophages and biomaterial surfaces. In this work, the polarization 
      behavior of mouse bone marrow-derived macrophages (BMDMs), including their 
      morphology and expression of phenotypic markers, genes and cytokines, on charged 
      surfaces with different potential intensities was systematically explored. We 
      found that the charged surface could effectively promote BMDM polarization, and a 
      higher potential intensity was conducive to the upregulation of the polarization 
      of BMDMs into the M2 phenotype. Based on the analysis of the signaling pathways 
      involved in integrins (alphaMbeta2 and alpha5beta1) and the potassium ion channel (Kv1.3), a 
      possible underlying mechanism revealed that the integrin originated signaling 
      pathways could more dominantly regulate macrophage polarization to the M2 
      phenotype. The present work therefore demonstrates that the surface charge, as a 
      physicochemical property of material surfaces, could effectively regulate 
      macrophage polarizations, which may provide an immunoregulation view for the 
      surface design of biomaterials.
FAU - Wang, Zhiying
AU  - Wang Z
AD  - School of Materials Science and Engineering, State Key Laboratory of Silicon 
      Materials, Zhejiang University, Hangzhou 310027, China. wengwj@zju.edu.cn.
FAU - He, Xuzhao
AU  - He X
AD  - School of Materials Science and Engineering, State Key Laboratory of Silicon 
      Materials, Zhejiang University, Hangzhou 310027, China. wengwj@zju.edu.cn.
FAU - Tang, Bolin
AU  - Tang B
AUID- ORCID: 0000-0003-2920-160X
AD  - College of Materials and Textile Engineering, Jiaxing University, Jiaxing 314001, 
      China. bltang@zjxu.edu.cn.
FAU - Chen, Xiaoyi
AU  - Chen X
AD  - The Stomatologic Hospital, School of Medicine, Zhejiang University, Hangzhou 
      310003, China. blankie@zju.edu.cn.
FAU - Dong, Lingqing
AU  - Dong L
AUID- ORCID: 0000-0002-2203-3212
AD  - The Stomatologic Hospital, School of Medicine, Zhejiang University, Hangzhou 
      310003, China. blankie@zju.edu.cn.
FAU - Cheng, Kui
AU  - Cheng K
AUID- ORCID: 0000-0003-4828-6450
AD  - School of Materials Science and Engineering, State Key Laboratory of Silicon 
      Materials, Zhejiang University, Hangzhou 310027, China. wengwj@zju.edu.cn.
FAU - Weng, Wenjian
AU  - Weng W
AUID- ORCID: 0000-0002-9373-7284
AD  - School of Materials Science and Engineering, State Key Laboratory of Silicon 
      Materials, Zhejiang University, Hangzhou 310027, China. wengwj@zju.edu.cn.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Biomater Sci
JT  - Biomaterials science
JID - 101593571
RN  - 0 (Cytokines)
SB  - IM
MH  - Animals
MH  - Cytokines/genetics
MH  - *Macrophage Activation
MH  - *Macrophages
MH  - Mice
MH  - Phenotype
MH  - Signal Transduction
EDAT- 2020/11/26 06:00
MHDA- 2021/05/15 06:00
CRDT- 2020/11/25 08:37
PHST- 2020/11/26 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2020/11/25 08:37 [entrez]
AID - 10.1039/d0bm01604g [doi]
PST - ppublish
SO  - Biomater Sci. 2021 Feb 9;9(3):874-881. doi: 10.1039/d0bm01604g.