PMID- 33238466
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221216
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 9
IP  - 11
DP  - 2020 Nov 23
TI  - Automated CT Analysis of Major Forms of Interstitial Lung Disease.
LID - 10.3390/jcm9113776 [doi]
LID - 3776
AB  - This study aimed to determine diagnostic and prognostic differences in major 
      forms of interstitial lung disease using quantitative CT imaging. A retrospective 
      study of 225 subjects with a multidisciplinary diagnosis of idiopathic pulmonary 
      fibrosis (IPF), interstitial pneumonia with autoimmune features (IPAF), 
      connective tissue disease (CTD), or chronic hypersensitivity pneumonitis (cHP) 
      was conducted. Non-contrast CT scans were analyzed using the Computer Aided Lung 
      Informatics for Pathology Evaluation and Rating (CALIPER) program. Resulting data 
      were analyzed statistically using ANOVA and Student's t-test. Univariate, 
      multivariable, and receiver operating characteristic analyses were conducted on 
      patient mortality data. CALIPER analysis of axial distribution on CT scans in 
      those with IPF demonstrated greater peripheral volumes of reticulation than 
      either CTD (p = 0.033) or cHP (p = 0.007). CTD showed lower peripheral 
      ground-glass opacity than IPF (p = 0.005) and IPAF (p = 0.004). Statistical 
      analysis of zonal distributions revealed reduced lower zone ground-glass opacity 
      in cHP than IPF (p = 0.044) or IPAF (p = 0.018). Analysis of pulmonary 
      vascular-related structure (VRS) volume by diagnosis indicated greater VRS volume 
      in IPF compared to CTD (p = 0.003) and cHP (p = 0.003) as well as in IPAF 
      compared to CTD (p = 0.007) and cHP (p = 0.007). Increased reticulation (p = 
      0.043) and ground glass opacity (p = 0.032) were predictive of mortality on 
      univariate analysis. Increased pulmonary VRS volume was predictive of mortality 
      (p < 0.001) even after multivariate analysis (p = 0.041). Quantitative CT imaging 
      revealed significant differences between ILD diagnoses in specific CT findings in 
      axial and, to a lesser degree, zonal distributions. Increased pulmonary VRS 
      volume seems to be associated with both diagnosis and survival.
FAU - Crews, Marlee S
AU  - Crews MS
AUID- ORCID: 0000-0002-2240-0983
AD  - Department of Radiology, The University of Chicago Medicine, Chicago, IL 60637, 
      USA.
FAU - Bartholmai, Brian J
AU  - Bartholmai BJ
AUID- ORCID: 0000-0001-7834-6579
AD  - Department of Radiology, Mayo Clinic, Rochester, MN 55902, USA.
FAU - Adegunsoye, Ayodeji
AU  - Adegunsoye A
AD  - Department of Medicine, The University of Chicago Medicine, Chicago, IL 60637, 
      USA.
FAU - Oldham, Justin M
AU  - Oldham JM
AD  - Department of Medicine, The University of California Davis, Sacramento, CA 95616, 
      USA.
FAU - Montner, Steven M
AU  - Montner SM
AD  - Department of Radiology, The University of Chicago Medicine, Chicago, IL 60637, 
      USA.
FAU - Karwoski, Ronald A
AU  - Karwoski RA
AD  - Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 
      55902, USA.
FAU - Husain, Aliya N
AU  - Husain AN
AD  - Department of Pathology, The University of Chicago Medicine, Chicago, IL 60637, 
      USA.
FAU - Vij, Rekha
AU  - Vij R
AD  - Department of Medicine, The University of Chicago Medicine, Chicago, IL 60637, 
      USA.
FAU - Noth, Imre
AU  - Noth I
AD  - Department of Medicine, University of Virginia, Charlottesville, VA 22903, USA.
FAU - Strek, Mary E
AU  - Strek ME
AD  - Department of Medicine, The University of Chicago Medicine, Chicago, IL 60637, 
      USA.
FAU - Chung, Jonathan H
AU  - Chung JH
AD  - Department of Radiology, The University of Chicago Medicine, Chicago, IL 60637, 
      USA.
LA  - eng
GR  - K23 HL138190/HL/NHLBI NIH HHS/United States
GR  - R01 HL130796/HL/NHLBI NIH HHS/United States
PT  - Journal Article
DEP - 20201123
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC7700631
OTO - NOTNLM
OT  - connective tissue disease
OT  - high-resolution computed tomography
OT  - hypersensitivity pneumonitis
OT  - idiopathic pulmonary fibrosis
OT  - interstitial pneumonia with autoimmune features
COIS- The authors declare no conflict of interest.
EDAT- 2020/11/27 06:00
MHDA- 2020/11/27 06:01
PMCR- 2020/11/23
CRDT- 2020/11/26 01:01
PHST- 2020/10/22 00:00 [received]
PHST- 2020/11/13 00:00 [revised]
PHST- 2020/11/19 00:00 [accepted]
PHST- 2020/11/26 01:01 [entrez]
PHST- 2020/11/27 06:00 [pubmed]
PHST- 2020/11/27 06:01 [medline]
PHST- 2020/11/23 00:00 [pmc-release]
AID - jcm9113776 [pii]
AID - jcm-09-03776 [pii]
AID - 10.3390/jcm9113776 [doi]
PST - epublish
SO  - J Clin Med. 2020 Nov 23;9(11):3776. doi: 10.3390/jcm9113776.