PMID- 33238656
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201201
IS  - 2075-4418 (Print)
IS  - 2075-4418 (Electronic)
IS  - 2075-4418 (Linking)
VI  - 10
IP  - 11
DP  - 2020 Nov 23
TI  - Usefulness of the IgA and IgG Responses to Macrophage Migration Inhibitory Factor 
      for the Diagnosis of Tuberculosis.
LID - 10.3390/diagnostics10110991 [doi]
LID - 991
AB  - Serological tests offer the potential in order to improve the diagnosis of 
      tuberculosis (TB). Macrophage migration inhibitory factor (MIF) plays a 
      protective role in infection control in TB; however, to date, no studies on 
      antibody responses to MIF have been reported. We measured immunoglobulin (Ig)A 
      and IgG responses to MIF in individuals with either active tuberculosis (ATB; n = 
      65), latent tuberculosis (LTBI; n = 53), or in non-infected individuals (NI; n = 
      62). The QuantiFERON-TB Gold In-Tube (QFT-GIT) assay was used in order to screen 
      for LTBI. The level of IgA against MIF was significantly lower in LTBI and ATB 
      patients than in NI individuals, was significantly related to LTBI and ATB 
      diagnosis, and it could discriminate between LTBI and ATB. In contrast, the level 
      of IgG against MIF was significantly lower in LTBI patients than in NI 
      individuals and was significantly related to LTBI diagnosis. Anti-MIF IgG levels 
      were significantly lower in AFB-negative TB, minimal TB, and new ATB patients, 
      than in the NI group. IgA and IgG levels against MIF both showed significant 
      negative correlations with IFN-gamma levels, as assessed using the QFT-GIT test. 
      Although none of the antibodies could achieve high diagnostic predictive power 
      individually, our results suggest the possibility of using IgA antibody responses 
      to MIF in the diagnosis of LTBI and ATB.
FAU - Lee, Ji Yeon
AU  - Lee JY
AUID- ORCID: 0000-0002-7026-8235
AD  - Division of Pulmonary and Critical Care Medicine, Department of Internal 
      Medicine, National Medical Center, Seoul 04564, Korea.
AD  - Department of Biomedical Sciences, Microbiology and Immunology and Liver Research 
      Institute, Seoul National University College of Medicine, Seoul 03080, Korea.
FAU - Kim, Byoung-Jun
AU  - Kim BJ
AD  - Department of Biomedical Sciences, Microbiology and Immunology and Liver Research 
      Institute, Seoul National University College of Medicine, Seoul 03080, Korea.
FAU - Kim, Jee-Min
AU  - Kim JM
AD  - Division of Pulmonary and Critical Care Medicine, Department of Internal 
      Medicine, National Medical Center, Seoul 04564, Korea.
FAU - Kim, Junghyun
AU  - Kim J
AD  - Division of Pulmonary and Critical Care Medicine, Department of Internal 
      Medicine, National Medical Center, Seoul 04564, Korea.
FAU - Joh, Joon-Sung
AU  - Joh JS
AD  - Division of Pulmonary and Critical Care Medicine, Department of Internal 
      Medicine, National Medical Center, Seoul 04564, Korea.
FAU - Jeong, Ina
AU  - Jeong I
AD  - Division of Pulmonary and Critical Care Medicine, Department of Internal 
      Medicine, National Medical Center, Seoul 04564, Korea.
FAU - Kook, Yoon-Hoh
AU  - Kook YH
AD  - Department of Biomedical Sciences, Microbiology and Immunology and Liver Research 
      Institute, Seoul National University College of Medicine, Seoul 03080, Korea.
FAU - Kim, Bum-Joon
AU  - Kim BJ
AUID- ORCID: 0000-0003-0085-6709
AD  - Department of Biomedical Sciences, Microbiology and Immunology and Liver Research 
      Institute, Seoul National University College of Medicine, Seoul 03080, Korea.
LA  - eng
GR  - 03-2017-0040/Seoul National University Hospital/
GR  - 03-2018-0050/Seoul National University Hospital/
GR  - NMC2017-MS-05/National Medical Center/
GR  - NMC2020-MS-03/National Medical Center/
PT  - Journal Article
DEP - 20201123
PL  - Switzerland
TA  - Diagnostics (Basel)
JT  - Diagnostics (Basel, Switzerland)
JID - 101658402
PMC - PMC7700399
OTO - NOTNLM
OT  - biomarkers
OT  - cytokines
OT  - diagnosis
OT  - macrophage migration inhibitory factor
OT  - serology
OT  - tuberculosis
COIS- The authors declare no conflict of interest.
EDAT- 2020/11/27 06:00
MHDA- 2020/11/27 06:01
PMCR- 2020/11/23
CRDT- 2020/11/26 01:01
PHST- 2020/09/22 00:00 [received]
PHST- 2020/10/21 00:00 [revised]
PHST- 2020/11/20 00:00 [accepted]
PHST- 2020/11/26 01:01 [entrez]
PHST- 2020/11/27 06:00 [pubmed]
PHST- 2020/11/27 06:01 [medline]
PHST- 2020/11/23 00:00 [pmc-release]
AID - diagnostics10110991 [pii]
AID - diagnostics-10-00991 [pii]
AID - 10.3390/diagnostics10110991 [doi]
PST - epublish
SO  - Diagnostics (Basel). 2020 Nov 23;10(11):991. doi: 10.3390/diagnostics10110991.