PMID- 33238897
OWN - NLM
STAT- MEDLINE
DCOM- 20211029
LR  - 20211029
IS  - 1471-2369 (Electronic)
IS  - 1471-2369 (Linking)
VI  - 21
IP  - 1
DP  - 2020 Nov 25
TI  - Association of higher arterial ketone body ratio (acetoacetate/beta-hydroxybutyrate) 
      with relevant nutritional marker in hemodialysis patients.
PG  - 510
LID - 10.1186/s12882-020-02173-1 [doi]
LID - 510
AB  - BACKGROUND: An association of higher levels of beta-hydroxybutyrate (beta-HB) in serum 
      with greater mortality in hemodialysis (HD) patients has been reported. This 
      study examined the significance of arterial ketone body ratio (AcAc/beta-HB), a 
      relevant marker of energy state, in HD patients. METHODS: The levels of arterial 
      AcAc and beta-HB, and AcAc/beta-HB ratio were determined in 49 HD patients just before 
      undergoing an HD session. Additionally, changes in those levels during the 
      session were examined to investigate their associations with clinical nutritional 
      markers. RESULTS: Arterial beta-HB, but not AcAc, was significantly higher at the 
      baseline in 25 patients with type 2 diabetes mellitus (T2DM) as compared to 24 
      non-DM patients, with a significant reduction in arterial AcAc/beta-HB ratio seen in 
      those with DM. Although the arterial AcAc/beta-HB ratio before the HD session was 
      significantly higher in the non-DM group, it did not differ significantly after 
      the session between the groups, indicating a faster rate of beta-HB disappearance 
      from circulation in non-DM HD patients during the interdialytic period. Multiple 
      regression analysis, which included age, gender, presence/absence of DM, log HD 
      duration, log beta-HB, and log AcAc/beta-HB ratio as independent variables, revealed an 
      independent and significant association of log AcAc/ beta-HB ratio, but not log 
      beta-HB, with serum albumin and uric acid. CONCLUSION: We found that a decreased 
      AcAc/beta-HB ratio resulting from increased beta-HB, but not increased beta-HB itself, was 
      a significant factor independently associated with decreased levels of serum 
      albumin and uric acid, known to be related to higher mortality in HD patients. 
      Furthermore, it is possible that higher mortality in DM HD patients can be 
      explained by reduced arterial AcAc/beta-HB ratio.
FAU - Inaba, Masaaki
AU  - Inaba M
AD  - Kidney Center, Ohno Memorial Hospital, 1-26-10, Minami-Horie, Nishi-ku, Osaka, 
      550-0015, Japan. m-inaba@ohno.or.jp.
FAU - Kumeda, Yasuro
AU  - Kumeda Y
AD  - Dialysis Center, Minami-Osaka Hospital, 1-18-18, Higashi-kagaya, Suminoe-ku, 
      Osaka, 559-0012, Japan.
FAU - Yamada, Shinsuke
AU  - Yamada S
AD  - Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City 
      University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, 
      545-8585, Japan.
FAU - Toi, Norikazu
AU  - Toi N
AD  - Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City 
      University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, 
      545-8585, Japan.
FAU - Hamai, Chie
AU  - Hamai C
AD  - Dialysis Center, Minami-Osaka Hospital, 1-18-18, Higashi-kagaya, Suminoe-ku, 
      Osaka, 559-0012, Japan.
FAU - Noguchi, Koichi
AU  - Noguchi K
AD  - Dialysis Center, Minami-Osaka Hospital, 1-18-18, Higashi-kagaya, Suminoe-ku, 
      Osaka, 559-0012, Japan.
FAU - Yasuda, Eikichi
AU  - Yasuda E
AD  - Dialysis Center, Minami-Osaka Hospital, 1-18-18, Higashi-kagaya, Suminoe-ku, 
      Osaka, 559-0012, Japan.
FAU - Furumitsu, Yutaka
AU  - Furumitsu Y
AD  - Kidney Center, Ohno Memorial Hospital, 1-26-10, Minami-Horie, Nishi-ku, Osaka, 
      550-0015, Japan.
FAU - Emoto, Masanori
AU  - Emoto M
AD  - Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City 
      University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, 
      545-8585, Japan.
FAU - Ohno, Yoshiteru
AU  - Ohno Y
AD  - Kidney Center, Ohno Memorial Hospital, 1-26-10, Minami-Horie, Nishi-ku, Osaka, 
      550-0015, Japan.
LA  - eng
PT  - Journal Article
DEP - 20201125
PL  - England
TA  - BMC Nephrol
JT  - BMC nephrology
JID - 100967793
RN  - 0 (Acetoacetates)
RN  - 0 (Biomarkers)
RN  - 0 (Serum Albumin)
RN  - 268B43MJ25 (Uric Acid)
RN  - TZP1275679 (3-Hydroxybutyric Acid)
SB  - IM
MH  - 3-Hydroxybutyric Acid/*blood
MH  - Acetoacetates/*blood
MH  - Aged
MH  - Biomarkers/blood
MH  - Diabetes Mellitus, Type 2/*blood/complications
MH  - Female
MH  - Humans
MH  - Kidney Failure, Chronic/*blood/complications/therapy
MH  - Male
MH  - Middle Aged
MH  - Regression Analysis
MH  - *Renal Dialysis
MH  - Serum Albumin/analysis
MH  - Uric Acid/blood
PMC - PMC7690103
OTO - NOTNLM
OT  - Albumin
OT  - Hemodialysis
OT  - Ketone
OT  - Ketone body ratio
OT  - Uric acid
COIS- The authors have no relevant financial interests to declare.
EDAT- 2020/11/27 06:00
MHDA- 2021/10/30 06:00
PMCR- 2020/11/25
CRDT- 2020/11/26 05:29
PHST- 2020/08/05 00:00 [received]
PHST- 2020/11/17 00:00 [accepted]
PHST- 2020/11/26 05:29 [entrez]
PHST- 2020/11/27 06:00 [pubmed]
PHST- 2021/10/30 06:00 [medline]
PHST- 2020/11/25 00:00 [pmc-release]
AID - 10.1186/s12882-020-02173-1 [pii]
AID - 2173 [pii]
AID - 10.1186/s12882-020-02173-1 [doi]
PST - epublish
SO  - BMC Nephrol. 2020 Nov 25;21(1):510. doi: 10.1186/s12882-020-02173-1.