PMID- 33239762
OWN - NLM
STAT- MEDLINE
DCOM- 20211025
LR  - 20230202
IS  - 1476-5454 (Electronic)
IS  - 0950-222X (Print)
IS  - 0950-222X (Linking)
VI  - 35
IP  - 10
DP  - 2021 Oct
TI  - Retinal and circumpapillary nerve fiber layer thickness and associated factors in 
      children.
PG  - 2802-2811
LID - 10.1038/s41433-020-01313-z [doi]
AB  - OBJECTIVE: To evaluate the distribution of macula and circumpapillary retina 
      nerve fiber layer (cpRNFL) thickness and other associated factors among grade-1 
      primary school children in Lhasa using spectral-domain optical coherence 
      tomography (SD-OCT). METHODOLOGY: OCT assessment was conducted on 1856 grade-1 
      students from 7 primary schools in Lhasa, Tibet following a successful random 
      stratified sampling of the students. Each child underwent comprehensive general 
      and ocular examinations as well as an SD-OCT detection (12 x 9 mm, 3D wide scan 
      mode, Topcon 3D OCT-1) to assess the thickness of the macula, ganglion cell-inner 
      plexiform layer (GCIPL), ganglion cell complex (GCC), and cpRNFL. Multivariate 
      and correlation analyses were performed to evaluate the association of the 
      demographic and ocular variables. RESULTS: The average age of the 1762 (94.43%) 
      students who underwent OCT assessment was 6.83 +/- 0.46 years. Among them, 984 
      (53.02%) were boys. The number of students who had macular, cpRNFL, and optic 
      disc scans completed and with adequate image quality were 1412 (82.2%), 1277 
      (74.4%), and 1243 (72.4%), respectively. The average macula full retinal 
      thickness (FRT), GCIPL, GCC, and cpRNFL thickness of the students was 
      279.19 +/- 10.61 mum, 76.41 +/- 4.70 mum, 108.15 +/- 6.15  mum, and 112.33 +/- 13.5 mum, 
      respectively. Multivariate regression and correlation analysis further revealed 
      that boys and girls had significant differences in their average cpRNFL 
      thickness. Moreover, GCC and GCIPL thickness was negatively correlated with IOP 
      but positively correlated with the body mass index. The thickness of all the 
      layers of the macula and cpRNFL were positively correlated with spherical 
      equivalent. Further to this, the average macular FRT, GCIPL, and GCC thicknesses 
      were positively correlated with cpRNFL global thickness. CONCLUSION: This study 
      describes the normal distribution of macular retina, cpRNFL, and optic disc 
      parameters in grade-1 Tibetan children in Lhasa. It contributes to the 
      establishment of a normative ophthalmology database of Tibetan children, and 
      advances the ability of OCT in ophthalmic disorder diagnosis during long-term 
      monitoring in plateau.
CI  - (c) 2020. The Author(s), under exclusive licence to The Royal College of 
      Ophthalmologists.
FAU - Yao, Yao
AU  - Yao Y
AUID- ORCID: 0000-0001-7947-2833
AD  - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 
      Beijing Key Laboratory of Ophthalmology & Visual Sciences, Beijing, China.
FAU - Fu, Jing
AU  - Fu J
AUID- ORCID: 0000-0002-2939-9479
AD  - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 
      Beijing Key Laboratory of Ophthalmology & Visual Sciences, Beijing, China. 
      fu_jing@126.com.
FAU - Li, Lei
AU  - Li L
AD  - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 
      Beijing Key Laboratory of Ophthalmology & Visual Sciences, Beijing, China.
FAU - Chen, Weiwei
AU  - Chen W
AD  - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 
      Beijing Key Laboratory of Ophthalmology & Visual Sciences, Beijing, China.
AD  - Beijing Institute of Ophthalmology, Beijing, China.
FAU - Meng, Zhaojun
AU  - Meng Z
AD  - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 
      Beijing Key Laboratory of Ophthalmology & Visual Sciences, Beijing, China.
FAU - Su, Han
AU  - Su H
AUID- ORCID: 0000-0003-3981-4143
AD  - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 
      Beijing Key Laboratory of Ophthalmology & Visual Sciences, Beijing, China.
FAU - Dai, Wei
AU  - Dai W
AD  - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 
      Beijing Key Laboratory of Ophthalmology & Visual Sciences, Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20201125
PL  - England
TA  - Eye (Lond)
JT  - Eye (London, England)
JID - 8703986
SB  - IM
MH  - Child
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - *Macula Lutea/diagnostic imaging
MH  - Male
MH  - Nerve Fibers
MH  - *Optic Disk/diagnostic imaging
MH  - Retina/diagnostic imaging
MH  - Retinal Ganglion Cells
MH  - Tomography, Optical Coherence
PMC - PMC8452704
COIS- The authors declare that they have no conflict of interest.
EDAT- 2020/11/27 06:00
MHDA- 2021/10/26 06:00
PMCR- 2022/10/01
CRDT- 2020/11/26 05:42
PHST- 2020/04/27 00:00 [received]
PHST- 2020/11/09 00:00 [accepted]
PHST- 2020/11/03 00:00 [revised]
PHST- 2020/11/27 06:00 [pubmed]
PHST- 2021/10/26 06:00 [medline]
PHST- 2020/11/26 05:42 [entrez]
PHST- 2022/10/01 00:00 [pmc-release]
AID - 10.1038/s41433-020-01313-z [pii]
AID - 1313 [pii]
AID - 10.1038/s41433-020-01313-z [doi]
PST - ppublish
SO  - Eye (Lond). 2021 Oct;35(10):2802-2811. doi: 10.1038/s41433-020-01313-z. Epub 2020 
      Nov 25.