PMID- 33240925
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201127
IS  - 2296-875X (Print)
IS  - 2296-875X (Electronic)
IS  - 2296-875X (Linking)
VI  - 7
DP  - 2020
TI  - Lymphoma of the Sublingual Gland: Clinical, Morphological, Histopathological, and 
      Genetic Characterization.
PG  - 581105
LID - 10.3389/fsurg.2020.581105 [doi]
LID - 581105
AB  - Background: Lymphoma of the sublingual gland is rare, representing 1% of all 
      salivary gland lymphomas. In this case report, we present three new cases and 
      compare them to previously published cases, with the aim of characterizing the 
      clinical, morphological, histopathological, and genetic features of this type of 
      malignancy. Materials and Methods: We provide a clinical description of three 
      cases along with a characterization of the microscopic features, including 
      morphology, and immunohistochemistry. In addition, we analysed possible 
      cytogenetic rearrangements with the use of fluorescence in situ hybridization 
      (FISH). Results: Case 1: A 61-year-old male presenting with a painless swelling 
      of the floor of the mouth diagnosed as extranodal marginal zone lymphoma (EMZL) 
      of the left sublingual gland. The patient is alive with no evidence of disease 
      after his fourth treatment regimen following several relapses. Case 2: A 
      68-year-old female with a prior history of mantle cell lymphoma (MCL) presenting 
      with a tender swelling of the left sublingual gland as well as the right 
      submandibular gland. The lesions were diagnosed as relapsing MCL. The patient 
      died of unrelated causes after 18 months of treatment. Case 3: A 75-year-old 
      female presenting with a swelling of the floor of the mouth diagnosed as 
      follicular lymphoma (FL) of the left sublingual gland. The patient received 
      chemotherapy along with radiotherapy and was still alive 10 years after the 
      diagnosis. Conclusion: The three cases of sublingual gland lymphomas presented in 
      this case report resemble lymphomas of other major salivary glands. The clinician 
      should be aware of this type of malignancy and that the clinical presentation may 
      not differ from benign lesions or other more common malignancies in this 
      location.
CI  - Copyright (c) 2020 Iversen, Eriksen, Andreasen, Clasen-Linde, Homoe, Wessel, von 
      Buchwald and Heegaard.
FAU - Iversen, Lars
AU  - Iversen L
AD  - Department of Ophthalmology, Rigshospitalet-Glostrup, Glostrup, Denmark.
AD  - Department of Pathology, Rigshospitalet, Copenhagen, Denmark.
FAU - Eriksen, Patrick Rene Gerhard
AU  - Eriksen PRG
AD  - Department of Otorhinolaryngology and Maxillofacial Surgery, Zealand University 
      Hospital, Koge, Denmark.
FAU - Andreasen, Simon
AU  - Andreasen S
AD  - Department of Pathology, Rigshospitalet, Copenhagen, Denmark.
AD  - Department of Otorhinolaryngology Head & Neck Surgery and Audiology, 
      Rigshospitalet, Copenhagen, Denmark.
FAU - Clasen-Linde, Erik
AU  - Clasen-Linde E
AD  - Department of Pathology, Rigshospitalet, Copenhagen, Denmark.
FAU - Homoe, Preben
AU  - Homoe P
AD  - Department of Otorhinolaryngology Head & Neck Surgery and Audiology, 
      Rigshospitalet, Copenhagen, Denmark.
FAU - Wessel, Irene
AU  - Wessel I
AD  - Department of Otorhinolaryngology and Maxillofacial Surgery, Zealand University 
      Hospital, Koge, Denmark.
FAU - von Buchwald, Christian
AU  - von Buchwald C
AD  - Department of Otorhinolaryngology and Maxillofacial Surgery, Zealand University 
      Hospital, Koge, Denmark.
FAU - Heegaard, Steffen
AU  - Heegaard S
AD  - Department of Ophthalmology, Rigshospitalet-Glostrup, Glostrup, Denmark.
AD  - Department of Pathology, Rigshospitalet, Copenhagen, Denmark.
LA  - eng
PT  - Case Reports
DEP - 20201106
PL  - Switzerland
TA  - Front Surg
JT  - Frontiers in surgery
JID - 101645127
PMC - PMC7677352
OTO - NOTNLM
OT  - extranodal marginal zone lymphoma
OT  - follicular lymphoma
OT  - head and neck
OT  - lymphoma
OT  - mantle cell lymphoma
OT  - salivary glands
OT  - sublingual glands
EDAT- 2020/11/27 06:00
MHDA- 2020/11/27 06:01
PMCR- 2020/11/06
CRDT- 2020/11/26 05:48
PHST- 2020/07/07 00:00 [received]
PHST- 2020/09/25 00:00 [accepted]
PHST- 2020/11/26 05:48 [entrez]
PHST- 2020/11/27 06:00 [pubmed]
PHST- 2020/11/27 06:01 [medline]
PHST- 2020/11/06 00:00 [pmc-release]
AID - 10.3389/fsurg.2020.581105 [doi]
PST - epublish
SO  - Front Surg. 2020 Nov 6;7:581105. doi: 10.3389/fsurg.2020.581105. eCollection 
      2020.