PMID- 33241090
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220418
IS  - 2352-0477 (Print)
IS  - 2352-0477 (Electronic)
IS  - 2352-0477 (Linking)
VI  - 7
DP  - 2020
TI  - Novel multi-linear quantitative brain volume formula for manual radiological 
      evaluation of brain atrophy.
PG  - 100281
LID - 10.1016/j.ejro.2020.100281 [doi]
LID - 100281
AB  - OBJECTIVES: The brain atrophy commonly occurs in elderly and in some childhood 
      conditions making the techniques for quantifying brain volume needful. Since the 
      automated quantitative methods of brain volume assessment have limited 
      availability in developing countries, it was the purpose of this study to design 
      and test an alternative formula that is applicable to all healthcare levels. 
      METHODS: The multi-linear diagonal brain fraction formula (DBF) was designed from 
      dimensions of brain relative to skull and ventricles. To test a developed 
      formula, a total of 347 subjects aged between 0 and 18 years who had brain CT 
      scans performed recruited and subjected to a systematic measurement of their 
      brains in a diagonal brain fashion. RESULTS: Out of 347 patients evaluated, 62 
      subjects (17.8 %) were found to be cases of brain atrophy. The three radiological 
      measurements which included sulcal width (SW), ventricular width (VW) and Evans 
      Index (EI) were concurrently performed. SW and VW showed good age correlation. 
      Similar tests were extended to diagonal brain fraction (DBF) and skull vertical 
      horizontal ratio (VHR) in which DBF showed significant age correlation. 
      CONCLUSIONS: The DBF formula shows significant ability of differentiating changes 
      of brain volume suggesting that it can be utilized as an alternative brain 
      fraction quantification method bearing technical simplicity in assessing gross 
      brain volume. ADVANCES IN KNOWLEDGE: The designed formula is unique in that it 
      captures even the possible asymmetrical volume loss of brain through diagonal 
      lines. The proposed scores being in term of ratios give four grades of brain 
      atrophy.
CI  - (c) 2020 The Authors.
FAU - Sungura, R
AU  - Sungura R
AD  - Department of Health and Biomedical Sciences, School of Life Science and 
      Bioengineering, Nelson Mandela-African Institution of Science and Technology, 
      Arusha, Tanzania.
FAU - Mpolya, E
AU  - Mpolya E
AD  - Department of Health and Biomedical Sciences, School of Life Science and 
      Bioengineering, Nelson Mandela-African Institution of Science and Technology, 
      Arusha, Tanzania.
FAU - Spitsbergen, J M
AU  - Spitsbergen JM
AD  - Department of Biological Sciences, Western Michigan University, USA.
FAU - Onyambu, C
AU  - Onyambu C
AD  - Department of Diagnostic and Radiation Medicine, School of Health Sciences, 
      University of Nairobi, Kenya.
FAU - Sauli, E
AU  - Sauli E
AD  - Department of Health and Biomedical Sciences, School of Life Science and 
      Bioengineering, Nelson Mandela-African Institution of Science and Technology, 
      Arusha, Tanzania.
FAU - Vianney, J-M
AU  - Vianney JM
AD  - Department of Health and Biomedical Sciences, School of Life Science and 
      Bioengineering, Nelson Mandela-African Institution of Science and Technology, 
      Arusha, Tanzania.
LA  - eng
PT  - Journal Article
DEP - 20201113
PL  - England
TA  - Eur J Radiol Open
JT  - European journal of radiology open
JID - 101650225
PMC - PMC7674282
OTO - NOTNLM
OT  - BIANCA, Brain Intensity Abnormality Classification Algorithm
OT  - BPF, Brain parenchymal fraction
OT  - Brain atrophy
OT  - Brain volume
OT  - CD, Compact disc
OT  - CSF, Cerebral spina fluid
OT  - CT, Computerized tomography
OT  - DBF, Diagonal brain fraction
OT  - DVD, Digital versatile disc
OT  - EI, Evans index
OT  - KNCHREC, Kibong'oto, Nelson Mandela and Cedha Research and Ethical Committee
OT  - MRI, Magnetic resonance imaging
OT  - MTA, medial temporal atrophy
OT  - Neuroimaging
OT  - Quantification
OT  - SW, Sulcal width
OT  - VBM, Volume based morphometry
OT  - VHR, Vertical-horizontal ratio
OT  - VW, Ventricular width
COIS- The authors report no declarations of interest.
EDAT- 2020/11/27 06:00
MHDA- 2020/11/27 06:01
PMCR- 2020/11/13
CRDT- 2020/11/26 05:48
PHST- 2020/09/22 00:00 [received]
PHST- 2020/10/20 00:00 [accepted]
PHST- 2020/11/26 05:48 [entrez]
PHST- 2020/11/27 06:00 [pubmed]
PHST- 2020/11/27 06:01 [medline]
PHST- 2020/11/13 00:00 [pmc-release]
AID - S2352-0477(20)30070-8 [pii]
AID - 100281 [pii]
AID - 10.1016/j.ejro.2020.100281 [doi]
PST - epublish
SO  - Eur J Radiol Open. 2020 Nov 13;7:100281. doi: 10.1016/j.ejro.2020.100281. 
      eCollection 2020.