PMID- 33242776 OWN - NLM STAT- MEDLINE DCOM- 20210414 LR - 20210414 IS - 1525-5069 (Electronic) IS - 1525-5050 (Linking) VI - 113 DP - 2020 Dec TI - Clinical features and outcomes of nonconvulsive status epilepticus in a developing country: A 5-year retrospective study. PG - 107547 LID - S1525-5050(20)30727-7 [pii] LID - 10.1016/j.yebeh.2020.107547 [doi] AB - BACKGROUND: This study aimed to determine the frequency of electrographically confirmed nonconvulsive status epilepticus (NCSE) in a cohort suspected with this condition and to determine the demographic/clinical profile, treatment, and outcomes of these patients in the context of a developing country, the Philippines. METHODS: We conducted a retrospective study among patients with suspected with NCSE admitted in the Philippine General Hospital from 2014 to 2019. Using the Salzberg 2013 criteria to diagnose NCSE, three electroencephalographers independently reviewed the electroencephalogram (EEG) tracings of suspected patients and were blinded from the clinical information. Then, we obtained pertinent clinical data from the medical records of EEG-confirmed NCSE cases. RESULTS: Out of 89 patients suspected with NCSE and with available EEG tracings, information from a total of 14 patients (15.7%) with electrographically confirmed cases were included in the analysis. Median age was 52 ranging from 22 to 77 and female-to-male ratio was 1.3:1. The following conditions were associated with NCSE: intracranial tumor (n = 4), metabolic encephalopathy (n = 4), autoimmune encephalitis (n = 3), intracranial hemorrhage (n = 3), sepsis (n = 3), cardiac arrest (n = 2), hypoxic-ischemic injury (n = 2), antiepileptic withdrawal (n = 1), intracranial abscess (n = 1), head trauma (n = 1), and meningitis (n = 1). Three patients (21.4%) had relatively good clinical outcomes (mRS 0-2) while 6 patients (42.8%) had poor outcomes (mRS 3-5) at discharge. Five patients (35.7%) died due to medical/neurological complications. Our review of the literature showed that the profile of NCSE cases identified in our resource-limited institution strengthens the findings in other populations. CONCLUSION: Our data showed that approximately 1 in 6 patients who are suspected with NCSE may have electrographic evidence of NCSE in our setting. The most common etiologies associated with NCSE were intracranial tumors and metabolic conditions. Further studies may entail a prospective collection of data to validate the estimates of our study. CI - Copyright (c) 2020 Elsevier Inc. All rights reserved. FAU - Andal, Vida Margarette D AU - Andal VMD AD - Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines. Electronic address: vdandal@up.edu.ph. FAU - Espiritu, Adrian I AU - Espiritu AI AD - Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines; Department of Clinical Epidemiology, College of Medicine, University of the Philippines Manila, Manila, Philippines. Electronic address: aiespiritu@up.edu.ph. FAU - Geronimo, Maria Angelica G AU - Geronimo MAG AD - Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines; Electroencephalography Unit, Department of Neurosciences, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines. FAU - Salonga-Quimpo, Rhea Angela M AU - Salonga-Quimpo RAM AD - Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines; Electroencephalography Unit, Department of Neurosciences, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines; Department of Pediatrics, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines. FAU - Gosiengfiao, Katerina Tanya P AU - Gosiengfiao KTP AD - Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines; Electroencephalography Unit, Department of Neurosciences, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines. FAU - Fernandez, Marc Laurence L AU - Fernandez MLL AD - Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines; Electroencephalography Unit, Department of Neurosciences, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines. LA - eng PT - Journal Article DEP - 20201124 PL - United States TA - Epilepsy Behav JT - Epilepsy & behavior : E&B JID - 100892858 SB - IM MH - *Developing Countries MH - Electroencephalography MH - Female MH - Humans MH - Male MH - Middle Aged MH - Prospective Studies MH - Retrospective Studies MH - *Status Epilepticus/diagnosis/epidemiology OTO - NOTNLM OT - Clinical profile OT - Electroencephalography OT - Nonconvulsive status epilepticus OT - Outcomes OT - Philippines EDAT- 2020/11/27 06:00 MHDA- 2021/04/15 06:00 CRDT- 2020/11/26 20:12 PHST- 2020/08/21 00:00 [received] PHST- 2020/10/11 00:00 [revised] PHST- 2020/10/11 00:00 [accepted] PHST- 2020/11/27 06:00 [pubmed] PHST- 2021/04/15 06:00 [medline] PHST- 2020/11/26 20:12 [entrez] AID - S1525-5050(20)30727-7 [pii] AID - 10.1016/j.yebeh.2020.107547 [doi] PST - ppublish SO - Epilepsy Behav. 2020 Dec;113:107547. doi: 10.1016/j.yebeh.2020.107547. Epub 2020 Nov 24.