PMID- 33243245 OWN - NLM STAT- MEDLINE DCOM- 20210217 LR - 20210217 IS - 1476-069X (Electronic) IS - 1476-069X (Linking) VI - 19 IP - 1 DP - 2020 Nov 26 TI - Prenatal exposure to perfluoroalkyl substances and thyroid hormone concentrations in cord plasma in a Chinese birth cohort. PG - 127 LID - 10.1186/s12940-020-00679-7 [doi] LID - 127 AB - BACKGROUND: Evidence of associations between prenatal exposure to perfluoroalkyl substances (PFASs) and fetal thyroid hormones (THs) is controversial, and few studies have estimated the associations, while addressing the high correlations among multiple PFASs. We aimed to examine the associations between prenatal PFAS exposure and thyroid hormone concentrations in cord blood. METHODS: A total of 300 mother-infant pairs from the Shanghai-Minhang Birth Cohort Study were included. We measured the concentrations of eight PFASs in maternal plasma samples collected at 12-16 gestational weeks, as well as those of total thyroxine (T4), free T4 (FT4), total triiodothyronine (T3), free T3 (FT3), and thyroid stimulating hormone (TSH) in cord plasma. We estimated the associations between maternal PFAS concentrations and TH concentrations using linear regression and Bayesian kernel machine regression (BKMR) models. RESULTS: In BKMR models, higher PFAS mixture concentrations were associated with increased T3 concentrations, and there were suggestive associations with increased FT3 concentrations. For single-exposure effects in BKMR models, a change in PFDA, PFUdA, and PFOA concentrations from the 25th to 75th percentile was associated with a 0.04 (95%CrI: - 0.01, 0.09), 0.02 (95%CrI: - 0.03, 0.07), and 0.03 (95%CrI: - 0.001, 0.06) nmol/L increase in T3 concentrations, respectively. PFOA, PFNA, and PFDA were the predominant compounds in PFASs-FT3 associations, and the corresponding estimates were 0.11 (95% CrI: 0.02, 0.19), - 0.17 (95% CrI: - 0.28, - 0.07), and 0.12 (95% CrI: - 0.004, 0.24) pmol/L, respectively. A change in PFNA and PFOA concentrations from the 25th to 75th percentile was associated with a - 1.69 (95% CrI: - 2.98, - 0.41) muIU/mL decrease and a 1.51 (95% CrI: 0.48, 2.55) muIU/mL increase in TSH concentrations. The associations of PFOA and PFNA with T3/FT3 were more pronounced in boys, while those with TSH were more pronounced in girls. CONCLUSION: Our results suggest that prenatal exposure to multiple PFASs was associated with thyroid hormones in cord blood. However, individual PFAS had varied effects-differing in magnitude and direction-on fetal thyroid hormones. FAU - Liang, Hong AU - Liang H AD - Department of Social Medicine and Reproductive Epidemiology, National Health Commission Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, #779 Lao Hu Min Road, Shanghai, 200032, China. FAU - Wang, Ziliang AU - Wang Z AD - Department of Social Medicine and Reproductive Epidemiology, National Health Commission Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, #779 Lao Hu Min Road, Shanghai, 200032, China. FAU - Miao, Maohua AU - Miao M AD - Department of Social Medicine and Reproductive Epidemiology, National Health Commission Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, #779 Lao Hu Min Road, Shanghai, 200032, China. FAU - Tian, Youping AU - Tian Y AD - National Management Office of Neonatal Screening Project for CHD, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102, China. FAU - Zhou, Yan AU - Zhou Y AD - National Reference Laboratory of Dioxin, Institute of Health Inspection and Detection, Hubei Provincial Academy of Preventive Medicine, Hubei Provincial Center for Disease Control and Prevention, #6 Zhuo Daoquan North Road, Wuhan, 430079, China. FAU - Wen, Sheng AU - Wen S AD - National Reference Laboratory of Dioxin, Institute of Health Inspection and Detection, Hubei Provincial Academy of Preventive Medicine, Hubei Provincial Center for Disease Control and Prevention, #6 Zhuo Daoquan North Road, Wuhan, 430079, China. FAU - Chen, Yao AU - Chen Y AD - Department of Social Medicine and Reproductive Epidemiology, National Health Commission Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, #779 Lao Hu Min Road, Shanghai, 200032, China. FAU - Sun, Xiaowei AU - Sun X AD - Department of Social Medicine and Reproductive Epidemiology, National Health Commission Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, #779 Lao Hu Min Road, Shanghai, 200032, China. FAU - Yuan, Wei AU - Yuan W AUID- ORCID: 0000-0002-1122-6481 AD - Department of Social Medicine and Reproductive Epidemiology, National Health Commission Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, #779 Lao Hu Min Road, Shanghai, 200032, China. yuanwei11@yahoo.com. LA - eng GR - 2018YFC1002801/National Key Research and Development Program of China/International GR - 2016YFC1000505/National Key Research and Development Program of China/International GR - 16ZR1430100/Science and Technology Commission of Shanghai Municipality/International GR - 20ZR1448000/Science and Technology Commission of Shanghai Municipality/International GR - CX2017-06/Innovation-oriented Science and Technology Grant from NHC Key Laboratory of Reproduction Regulation/International PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20201126 PL - England TA - Environ Health JT - Environmental health : a global access science source JID - 101147645 RN - 0 (Alkanesulfonic Acids) RN - 0 (Carboxylic Acids) RN - 0 (Decanoic Acids) RN - 0 (Environmental Pollutants) RN - 0 (Fluorocarbons) RN - 06LU7C9H1V (Triiodothyronine) RN - 9002-71-5 (Thyrotropin) RN - Q51BO43MG4 (Thyroxine) SB - IM MH - Adolescent MH - Adult MH - Alkanesulfonic Acids/blood MH - Carboxylic Acids/blood MH - China MH - Cohort Studies MH - Decanoic Acids/blood MH - Environmental Pollutants/*blood MH - Female MH - Fetal Blood/*chemistry MH - Fluorocarbons/*blood MH - Humans MH - Infant, Newborn MH - Male MH - *Maternal Exposure MH - *Maternal-Fetal Exchange MH - Pregnancy MH - Thyrotropin/*blood MH - Thyroxine/blood MH - Triiodothyronine/*blood MH - Young Adult PMC - PMC7690128 OTO - NOTNLM OT - Bayesian kernel machine regression OT - Cord blood OT - Perfluoroalkyl substances OT - Prenatal exposure OT - Prospective cohort study OT - Thyroid hormones COIS- The authors declare that they have no competing financial interests. EDAT- 2020/11/28 06:00 MHDA- 2021/02/18 06:00 PMCR- 2020/11/26 CRDT- 2020/11/27 05:30 PHST- 2020/08/07 00:00 [received] PHST- 2020/11/13 00:00 [accepted] PHST- 2020/11/27 05:30 [entrez] PHST- 2020/11/28 06:00 [pubmed] PHST- 2021/02/18 06:00 [medline] PHST- 2020/11/26 00:00 [pmc-release] AID - 10.1186/s12940-020-00679-7 [pii] AID - 679 [pii] AID - 10.1186/s12940-020-00679-7 [doi] PST - epublish SO - Environ Health. 2020 Nov 26;19(1):127. doi: 10.1186/s12940-020-00679-7.