PMID- 33244785
OWN - NLM
STAT- MEDLINE
DCOM- 20210621
LR  - 20210621
IS  - 1439-0272 (Electronic)
IS  - 0303-4569 (Linking)
VI  - 53
IP  - 2
DP  - 2021 Mar
TI  - Cratoxylum formosum dyer extract alleviates testicular damage in hypertensive 
      rats.
PG  - e13917
LID - 10.1111/and.13917 [doi]
AB  - The effects of a Cratoxylum formosum (Jack) Dyer ssp. (CF) extract on testicular 
      damage were assessed in hypertensive rats. N(omega) -nitro-L-arginine methyl ester 
      hydrochloride (L-NAME; 40 mg kg(-1)  day(-1) ) was administered for 5 weeks to 
      induce hypertension in male Sprague-Dawley rats, and treated with CF extract 
      (100, 300 or 500 mg kg(-1)  day(-1) ) or sildenafil (5 mg kg(-1)  day(-1) ) 
      during the final 2 weeks (n = 8/group). Biochemical components of the CF extract 
      were identified and mainly contained phenolic compounds. The CF extract 
      significantly reduced systolic blood pressure and alleviated impaired sperm 
      quality and seminiferous tubular morphology in hypertensive rats. CF extract 
      restored reduced serum testosterone and protein expression of steroidogenic acute 
      regulatory protein (StAR), nuclear factor erythroid-related factor 2 (Nrf2), and 
      haem oxygenase 1 (HO-1) in L-NAME rats. Hypertensive rats presented decreased 
      antioxidant enzyme activities, and increased testicular and plasma 
      malondialdehyde (MDA) levels and superoxide production, all of which were 
      normalised by CF extract. Furthermore, endothelial nitric oxide synthase (eNOS) 
      expression in testicular tissue and plasma nitrate/nitrite levels were restored 
      in hypertensive rats administered CF extract. Conclusion: CF extract alleviated 
      testicular damage in hypertensive rats. Potential molecular mechanisms may 
      involve suppression of oxidative stress and restoration of StAR, Nrf2, HO-1 and 
      eNOS expression in hypertensive rats.
CI  - (c) 2020 Wiley-VCH GmbH.
FAU - Poasakate, Anuson
AU  - Poasakate A
AD  - Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 
      Thailand.
FAU - Maneesai, Putcharawipa
AU  - Maneesai P
AD  - Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 
      Thailand.
FAU - Chiangsaen, Petcharat
AU  - Chiangsaen P
AD  - Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 
      Thailand.
FAU - Bunbupha, Sarawoot
AU  - Bunbupha S
AD  - Faculty of Medicine, Mahasarakham University, Maha Sarakham, Thailand.
FAU - Settheetham-Ishida, Wannapa
AU  - Settheetham-Ishida W
AD  - Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 
      Thailand.
FAU - Pakdeechote, Poungrat
AU  - Pakdeechote P
AUID- ORCID: 0000-0001-8114-5954
AD  - Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 
      Thailand.
AD  - Research Institute for Human High Performance and Health Promotion, Khon Kaen 
      University, Khon Kaen, Thailand.
LA  - eng
GR  - Development and Promotion of Science and Technology Talents project (DPST)/
GR  - IN63205/Invitation Research Fund/
PT  - Journal Article
DEP - 20201126
PL  - Germany
TA  - Andrologia
JT  - Andrologia
JID - 0423506
RN  - 0 (Plant Extracts)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type III)
RN  - V55S2QJN2X (NG-Nitroarginine Methyl Ester)
SB  - IM
MH  - Animals
MH  - Blood Pressure
MH  - *Clusiaceae/metabolism
MH  - *Hypertension/drug therapy
MH  - Male
MH  - NG-Nitroarginine Methyl Ester
MH  - Nitric Oxide
MH  - Nitric Oxide Synthase Type III/metabolism
MH  - Oxidative Stress
MH  - Plant Extracts/pharmacology/therapeutic use
MH  - Rats
MH  - Rats, Sprague-Dawley
OTO - NOTNLM
OT  - Cratoxylum formosum
OT  - oxidative stress
OT  - phenolic compounds
OT  - testicular dysfunction
OT  - the nuclear factor erythroid-related factor 2
EDAT- 2020/11/28 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/11/27 05:47
PHST- 2020/08/03 00:00 [received]
PHST- 2020/11/02 00:00 [revised]
PHST- 2020/11/05 00:00 [accepted]
PHST- 2020/11/28 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/11/27 05:47 [entrez]
AID - 10.1111/and.13917 [doi]
PST - ppublish
SO  - Andrologia. 2021 Mar;53(2):e13917. doi: 10.1111/and.13917. Epub 2020 Nov 26.