PMID- 33246361
OWN - NLM
STAT- MEDLINE
DCOM- 20220329
LR  - 20220716
IS  - 1947-6043 (Electronic)
IS  - 1947-6035 (Print)
IS  - 1947-6035 (Linking)
VI  - 13
IP  - 1_suppl
DP  - 2021 Dec
TI  - Do Self-Reported Drug Allergies Influence Clinically Significant Outcome 
      Improvement Following Osteochondral Allograft Transplantation? A Nested Cohort 
      Study.
PG  - 868S-872S
LID - 10.1177/1947603520976770 [doi]
AB  - OBJECTIVE: To compare clinical outcomes for patients who underwent osteochondral 
      allograft transplantation (OCA) based on the presence or absence of one or more 
      self-reported drug allergies. DESIGN: Prospective data were collected from 245 
      consecutive patients after OCA of the knee from one large academic institution. 
      Patient-reported allergies were obtained via chart review. Patient-reported 
      outcome measures, including activities of daily living of the Knee Outcome Survey 
      (KOS-ADL), Marx Activity Scale, International Knee Documentation Committee 
      (IKDC), and visual analogue scale (VAS) pain were all collected. The minimal 
      clinically important difference (MCID) for each outcome was quantified using a 
      distribution-based method. Independent t tests were used to compare 
      patient-reported outcome measures between those with and without self-reported 
      allergies, while chi-square analysis of association was used to compare rates of 
      MCID achievement. RESULTS: Of 245 patients included, 83 (33.9%) reported having 
      at least one drug allergy at the time of OCA. There were no statistically 
      significant differences with regard to patient demographics, including age, body 
      mass index, gender, or sports participation between those with and without a 
      reported allergy. Similarly, there were no significant differences found between 
      baseline preoperative patient-reported outcomes. Overall, both cohorts 
      demonstrated a significant improvement from baseline scores at 2 years 
      postoperatively. There were no differences found between any patient-reported 
      outcome at 2 years postoperatively. The presence of at least one self-reported 
      drug allergy was not a significant risk factor for failing to achieve the MCID in 
      any specific outcome measure. CONCLUSIONS: The presence of one or more drug 
      allergy was not associated with worse patient-reported outcomes or lower rates of 
      clinically significant outcome improvement after OCA.
FAU - Wright-Chisem, Joshua I
AU  - Wright-Chisem JI
AUID- ORCID: 0000-0002-3760-388X
AD  - Hospital for Special Surgery, New York, NY, USA.
FAU - Cohn, Matthew R
AU  - Cohn MR
AUID- ORCID: 0000-0002-2647-0524
AD  - Rush University, Chicago, IL, USA.
FAU - Kunze, Kyle N
AU  - Kunze KN
AUID- ORCID: 0000-0002-0363-3482
AD  - Hospital for Special Surgery, New York, NY, USA.
FAU - Wright-Chisem, Adam
AU  - Wright-Chisem A
AD  - Cedars-Sinai Medical Center, Los Angeles, CA, USA.
FAU - Warner, Tyler
AU  - Warner T
AD  - Harvard Medical School, Brookline, MA, USA.
FAU - Hicks, Justin J
AU  - Hicks JJ
AD  - Washington University, Saint Louis, MO, USA.
FAU - Williams, Riley J
AU  - Williams RJ
AD  - Hospital for Special Surgery, New York, NY, USA.
LA  - eng
PT  - Journal Article
DEP - 20201127
PL  - United States
TA  - Cartilage
JT  - Cartilage
JID - 101518378
SB  - IM
MH  - Activities of Daily Living
MH  - Adult
MH  - Aged
MH  - Allografts/surgery
MH  - Bone Transplantation/adverse effects/*methods
MH  - Cartilage/*transplantation
MH  - Cartilage, Articular/*surgery
MH  - Cohort Studies
MH  - *Drug Hypersensitivity
MH  - Female
MH  - Humans
MH  - *Intra-Articular Fractures
MH  - Knee Joint/*pathology/*surgery
MH  - Male
MH  - Middle Aged
MH  - Patient Reported Outcome Measures
MH  - Prospective Studies
MH  - Self Report
MH  - Treatment Outcome
PMC - PMC8808784
OTO - NOTNLM
OT  - allergies
OT  - cartilage
OT  - osteochondral allograft
OT  - patient-reported allergies
COIS- Declaration of Conflicting Interests: The author(s) declared no potential 
      conflicts of interest with respect to the research, authorship, and/or 
      publication of this article.
EDAT- 2020/11/29 06:00
MHDA- 2022/03/30 06:00
PMCR- 2022/06/01
CRDT- 2020/11/28 05:22
PHST- 2020/11/29 06:00 [pubmed]
PHST- 2022/03/30 06:00 [medline]
PHST- 2020/11/28 05:22 [entrez]
PHST- 2022/06/01 00:00 [pmc-release]
AID - 10.1177_1947603520976770 [pii]
AID - 10.1177/1947603520976770 [doi]
PST - ppublish
SO  - Cartilage. 2021 Dec;13(1_suppl):868S-872S. doi: 10.1177/1947603520976770. Epub 
      2020 Nov 27.