PMID- 33246558
OWN - NLM
STAT- MEDLINE
DCOM- 20210419
LR  - 20210419
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 534
DP  - 2021 Jan 1
TI  - Effects of magnesium sulfate administration in attenuating chronic postsurgical 
      pain in rats.
PG  - 395-400
LID - S0006-291X(20)32113-6 [pii]
LID - 10.1016/j.bbrc.2020.11.069 [doi]
AB  - Chronic postsurgical pain (CPSP) is a serious issue for many postoperative 
      patients. Though there are numerous treatment options for the prevention of CPSP, 
      none of them is optimal as the mechanisms of the transition from acute to chronic 
      postoperative pain have not been elucidated. Ketamine and opioids have been 
      administered for chronic postoperative pain treatment but induce severe adverse 
      reactions and/or physical dependency. Here, we examined whether 
      pre-administration of the nonselective N-methyl-d-aspartate (NMDA) receptor 
      antagonist magnesium sulfate attenuates CPSP behavior and alters the expression 
      of glutamate ionotropic receptor NMDA type subunit 1a (Grin1 mRNA) in a rat 
      skin/muscle incision and retraction (SMIR) model. We assessed the effects of a 
      single subcutaneous magnesium sulfate injection on nociceptive behaviors 
      including guarding pain, mechanical hyperalgesia, and heat hypersensitivity in 
      rats after SMIR surgery. We used reverse transcription-quantitative PCR (RT-qPCR) 
      to evaluate Grin1 mRNA expression in the dorsal horn of the spinal cord on 
      postoperative day 14. Compared with the vehicle, magnesium sulfate administration 
      before SMIR surgery reduced mechanical hyperalgesia for 17 d Grin1 gene 
      expression was significantly higher on the ipsilateral side than the 
      contralateral side (P = 0.001) on postoperative day 14. The magnesium sulfate 
      injection prevented Grin1 mRNA upregulation in the spinal cord dorsal horn. A 
      single magnesium sulfate injection mitigated SMIR-induced mechanical hyperalgesia 
      possibly by modulating Grin1 expression. Preoperative magnesium sulfate 
      administration could prove to be a simple and safe CPSP treatment.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Kido, Kanta
AU  - Kido K
AD  - Department of Anesthesiology, Kanagawa Dental University Hospital, Yokosuka, 
      Kanagawa, Japan. Electronic address: kido@kdu.ac.jp.
FAU - Katagiri, Norika
AU  - Katagiri N
AD  - Department of Anesthesiology, Kanagawa Dental University Hospital, Yokosuka, 
      Kanagawa, Japan.
FAU - Kawana, Hiromasa
AU  - Kawana H
AD  - Department of Oral and Maxillofacial Implantology, Kanagawa Dental University 
      Hospital, Yokosuka, Kanagawa, Japan.
FAU - Sugino, Shigekazu
AU  - Sugino S
AD  - Department of Anesthesiology and Perioperative Medicine, Tohoku University School 
      of Medicine, Sendai, Miyagi, Japan.
FAU - Konno, Daisuke
AU  - Konno D
AD  - Department of Anesthesiology and Perioperative Medicine, Tohoku University School 
      of Medicine, Sendai, Miyagi, Japan.
FAU - Suzuki, Jun
AU  - Suzuki J
AD  - Department of Anesthesiology and Perioperative Medicine, Tohoku University School 
      of Medicine, Sendai, Miyagi, Japan.
FAU - Yamauchi, Masanori
AU  - Yamauchi M
AD  - Department of Anesthesiology and Perioperative Medicine, Tohoku University School 
      of Medicine, Sendai, Miyagi, Japan.
FAU - Sanuki, Takuro
AU  - Sanuki T
AD  - Department of Anesthesiology, Kanagawa Dental University Hospital, Yokosuka, 
      Kanagawa, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201125
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Analgesics)
RN  - 0 (NMDA receptor A1)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 7487-88-9 (Magnesium Sulfate)
SB  - IM
MH  - Analgesics/*administration & dosage
MH  - Animals
MH  - Disease Models, Animal
MH  - Drug Administration Schedule
MH  - Gene Expression/drug effects
MH  - Hyperalgesia/genetics/physiopathology/prevention & control
MH  - Injections, Subcutaneous
MH  - Magnesium Sulfate/*administration & dosage
MH  - Male
MH  - Pain, Postoperative/genetics/physiopathology/*prevention & control
MH  - Preoperative Period
MH  - RNA, Messenger/genetics/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, N-Methyl-D-Aspartate/genetics
MH  - Spinal Cord/drug effects/metabolism
MH  - Up-Regulation/drug effects
OTO - NOTNLM
OT  - Chronic postsurgical pain
OT  - Magnesium
OT  - N-methyl-d-aspartate receptor
OT  - Skin/muscle incision and retraction
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2020/11/29 06:00
MHDA- 2021/04/20 06:00
CRDT- 2020/11/28 05:27
PHST- 2020/11/03 00:00 [received]
PHST- 2020/11/16 00:00 [accepted]
PHST- 2020/11/29 06:00 [pubmed]
PHST- 2021/04/20 06:00 [medline]
PHST- 2020/11/28 05:27 [entrez]
AID - S0006-291X(20)32113-6 [pii]
AID - 10.1016/j.bbrc.2020.11.069 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2021 Jan 1;534:395-400. doi: 
      10.1016/j.bbrc.2020.11.069. Epub 2020 Nov 25.