PMID- 33247145
OWN - NLM
STAT- MEDLINE
DCOM- 20210322
LR  - 20210322
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 10
IP  - 1
DP  - 2020 Nov 27
TI  - Changes in hemodynamics, renal blood flow and urine output during continuous 
      renal replacement therapies.
PG  - 20797
LID - 10.1038/s41598-020-77435-x [doi]
LID - 20797
AB  - Continuous renal replacement therapies (CRRT) affect hemodynamics and urine 
      output. Some theories suggest a reduced renal blood flow as the cause of the 
      decreased urine output, but the exact mechanisms remain unclear. A prospective 
      experimental study was carried out in 32 piglets (2-3 months old) in order to 
      compare the impact of CRRT on hemodynamics, renal perfusion, urine output and 
      renal function in healthy animals and in those with non-oliguric acute kidney 
      injury (AKI). CRRT was started according to our clinical protocol, with an 
      initial blood flow of 20 ml/min, with 10 ml/min increases every minute until a 
      goal flow of 5 ml/kg/min. Heart rate, blood pressure, central venous pressure, 
      cardiac output, renal blood flow and urine output were registered at baseline and 
      during the first 6 h of CRRT. Blood and urine samples were drawn at baseline and 
      after 2 and 6 h of therapy. Blood pressure, cardiac index and urine output 
      significantly decreased after starting CRRT in all piglets. Renal blood flow, 
      however, steadily increased throughout the study. Cisplatin piglets had lower 
      cardiac index, higher vascular resistance, lower renal blood flow and lower urine 
      output than control piglets. Plasma levels of ADH and urine levels of aquaporin-2 
      were lower, whereas kidney injury biomarkers were higher in the cisplatin group 
      of piglets. According to our findings, a reduced renal blood flow doesn't seem to 
      be the cause of the decrease in urine output after starting CRRT.
FAU - Fernandez, S N
AU  - Fernandez SN
AD  - Pediatric Intensive Care Department, Gregorio Maranon General University 
      Hospital, Madrid, Spain. sarahlafever@gmail.com.
AD  - Department of Pediatrics. School of Medicine, Complutense University of Madrid, 
      Madrid, Spain. sarahlafever@gmail.com.
AD  - Health Research Institute of the Gregorio Maranon Hospital, Madrid, Spain. 
      sarahlafever@gmail.com.
FAU - Santiago, M J
AU  - Santiago MJ
AD  - Pediatric Intensive Care Department, Gregorio Maranon General University 
      Hospital, Madrid, Spain.
AD  - Department of Pediatrics. School of Medicine, Complutense University of Madrid, 
      Madrid, Spain.
AD  - Health Research Institute of the Gregorio Maranon Hospital, Madrid, Spain.
FAU - Gonzalez, R
AU  - Gonzalez R
AD  - Pediatric Intensive Care Department, Gregorio Maranon General University 
      Hospital, Madrid, Spain.
AD  - Department of Pediatrics. School of Medicine, Complutense University of Madrid, 
      Madrid, Spain.
AD  - Health Research Institute of the Gregorio Maranon Hospital, Madrid, Spain.
FAU - Lopez, J
AU  - Lopez J
AD  - Pediatric Intensive Care Department, Gregorio Maranon General University 
      Hospital, Madrid, Spain.
AD  - Department of Pediatrics. School of Medicine, Complutense University of Madrid, 
      Madrid, Spain.
AD  - Health Research Institute of the Gregorio Maranon Hospital, Madrid, Spain.
FAU - Solana, M J
AU  - Solana MJ
AD  - Pediatric Intensive Care Department, Gregorio Maranon General University 
      Hospital, Madrid, Spain.
AD  - Department of Pediatrics. School of Medicine, Complutense University of Madrid, 
      Madrid, Spain.
AD  - Health Research Institute of the Gregorio Maranon Hospital, Madrid, Spain.
FAU - Urbano, J
AU  - Urbano J
AUID- ORCID: 0000-0002-3511-2905
AD  - Pediatric Intensive Care Department, Gregorio Maranon General University 
      Hospital, Madrid, Spain.
AD  - Department of Pediatrics. School of Medicine, Complutense University of Madrid, 
      Madrid, Spain.
AD  - Health Research Institute of the Gregorio Maranon Hospital, Madrid, Spain.
FAU - Lopez-Herce, J
AU  - Lopez-Herce J
AD  - Pediatric Intensive Care Department, Gregorio Maranon General University 
      Hospital, Madrid, Spain.
AD  - Department of Pediatrics. School of Medicine, Complutense University of Madrid, 
      Madrid, Spain.
AD  - Health Research Institute of the Gregorio Maranon Hospital, Madrid, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201127
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Biomarkers)
SB  - IM
MH  - Acute Kidney Injury/physiopathology/therapy
MH  - Animals
MH  - Biomarkers/blood/urine
MH  - Blood Pressure
MH  - Child
MH  - Continuous Renal Replacement Therapy/*adverse effects
MH  - Disease Models, Animal
MH  - Female
MH  - *Hemodynamics
MH  - Humans
MH  - Male
MH  - Prospective Studies
MH  - *Renal Circulation
MH  - Swine
MH  - Swine, Miniature
MH  - *Urodynamics
MH  - Vascular Resistance
PMC - PMC7695709
COIS- The authors declare no competing interests.
EDAT- 2020/11/29 06:00
MHDA- 2021/03/23 06:00
PMCR- 2020/11/27
CRDT- 2020/11/28 05:32
PHST- 2018/12/18 00:00 [received]
PHST- 2020/11/09 00:00 [accepted]
PHST- 2020/11/28 05:32 [entrez]
PHST- 2020/11/29 06:00 [pubmed]
PHST- 2021/03/23 06:00 [medline]
PHST- 2020/11/27 00:00 [pmc-release]
AID - 10.1038/s41598-020-77435-x [pii]
AID - 77435 [pii]
AID - 10.1038/s41598-020-77435-x [doi]
PST - epublish
SO  - Sci Rep. 2020 Nov 27;10(1):20797. doi: 10.1038/s41598-020-77435-x.