PMID- 33248780 OWN - NLM STAT- MEDLINE DCOM- 20210112 LR - 20210112 IS - 1879-1026 (Electronic) IS - 0048-9697 (Linking) VI - 758 DP - 2021 Mar 1 TI - Human biomonitoring of persistent organic pollutants in elderly people from the Canary Islands (Spain): A temporal trend analysis from the PREDIMED and PREDIMED-Plus cohorts. PG - 143637 LID - S0048-9697(20)37168-0 [pii] LID - 10.1016/j.scitotenv.2020.143637 [doi] AB - The population of the Canary Islands has been exposed to high levels of persistent organic pollutants (POPs). Biomonitoring studies are essential to know the temporal trend in residue levels, particularly of substances banned decades ago. The purpose of this study was to analyze the distribution of plasma concentrations of 59 POPs in 175 participants from the PREDIMED-Plus trial (2014-2016), and to compare them with the distribution of these POPs in 343 participants in the PREDIMED trial (2006-2009). All participants had metabolic syndrome. No difference in the distribution of age, gender or BMI was observed between trials. POPs were determined by gas chromatography-mass spectrometry. Density plots -POP Geoffrey Rose curves- were used to represent the full population distribution of each compound. Three out of 59 POPs were detected and quantified in >/=95% of the samples (p,p'-DDE, median = 694.7 ng/g lipid; HCB, median = 57.0 ng/g lipid; and beta-HCH, median = 75.7 ng/g lipid). PCB congeners 138, 153 and 180 were detected in 64.6, 40.0 and 88.0% of the samples. Females showed highest concentrations of organochlorine pesticides and those subjects who lost > 5 kg showed significant higher plasma concentrations of POPs. In a range of 6-14 years, plasma concentrations of POPs decreased 3.3-21.6 fold, being notable the decrease of 28.7-fold observed for HCB among women. Despite this sharp decline, levels of POPs are still higher than those reported in other regions, since one third of the subjects included in the present report had high concentration of more than three pollutants. Continuous biomonitoring studies are required to know the evolution of the levels of residues and to evaluate the effectiveness of environmental policies. CI - Copyright (c) 2020 Elsevier B.V. All rights reserved. FAU - Henriquez-Hernandez, L A AU - Henriquez-Hernandez LA AD - Research Institute of Biomedical and Health Sciences (IUIBS), Universidad de Las Palmas de Gran Canaria, Paseo Blas Cabrera s/n, 35016, Las Palmas de Gran Canaria, Spain; CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Clinical Sciences Department, Universidad de Las Palmas de Gran Canaria, Canary Islands, Spain. Electronic address: luis.henriquez@ulpgc.es. FAU - Ortiz-Andrelluchi, A AU - Ortiz-Andrelluchi A AD - Research Institute of Biomedical and Health Sciences (IUIBS), Universidad de Las Palmas de Gran Canaria, Paseo Blas Cabrera s/n, 35016, Las Palmas de Gran Canaria, Spain; CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Clinical Sciences Department, Universidad de Las Palmas de Gran Canaria, Canary Islands, Spain. FAU - Alvarez-Perez, J AU - Alvarez-Perez J AD - Research Institute of Biomedical and Health Sciences (IUIBS), Universidad de Las Palmas de Gran Canaria, Paseo Blas Cabrera s/n, 35016, Las Palmas de Gran Canaria, Spain; CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Clinical Sciences Department, Universidad de Las Palmas de Gran Canaria, Canary Islands, Spain. FAU - Acosta-Dacal, A AU - Acosta-Dacal A AD - Research Institute of Biomedical and Health Sciences (IUIBS), Universidad de Las Palmas de Gran Canaria, Paseo Blas Cabrera s/n, 35016, Las Palmas de Gran Canaria, Spain; CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Clinical Sciences Department, Universidad de Las Palmas de Gran Canaria, Canary Islands, Spain. FAU - Zumbado, M AU - Zumbado M AD - Research Institute of Biomedical and Health Sciences (IUIBS), Universidad de Las Palmas de Gran Canaria, Paseo Blas Cabrera s/n, 35016, Las Palmas de Gran Canaria, Spain; CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Clinical Sciences Department, Universidad de Las Palmas de Gran Canaria, Canary Islands, Spain. FAU - Martinez-Gonzalez, M A AU - Martinez-Gonzalez MA AD - CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; University of Navarra, Department of Preventive Medicine and Public Health, IDISNA, 31008 Pamplona, Spain; Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, USA. FAU - Boada, L D AU - Boada LD AD - Research Institute of Biomedical and Health Sciences (IUIBS), Universidad de Las Palmas de Gran Canaria, Paseo Blas Cabrera s/n, 35016, Las Palmas de Gran Canaria, Spain; CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Clinical Sciences Department, Universidad de Las Palmas de Gran Canaria, Canary Islands, Spain. FAU - Salas-Salvado, J AU - Salas-Salvado J AD - CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Human Nutrition Unit, Biochemistry and Biotechnology Department, IISPV, Hospital Universitari de Sant Joan, Universitat Rovira i Virgili, 43201 Reus, Spain. FAU - Luzardo, O P AU - Luzardo OP AD - Research Institute of Biomedical and Health Sciences (IUIBS), Universidad de Las Palmas de Gran Canaria, Paseo Blas Cabrera s/n, 35016, Las Palmas de Gran Canaria, Spain; CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Clinical Sciences Department, Universidad de Las Palmas de Gran Canaria, Canary Islands, Spain. FAU - Serra-Majem, L AU - Serra-Majem L AD - Research Institute of Biomedical and Health Sciences (IUIBS), Universidad de Las Palmas de Gran Canaria, Paseo Blas Cabrera s/n, 35016, Las Palmas de Gran Canaria, Spain; CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Preventive Medicine Service, Centro Hospitalario Universitario Insular Materno Infantil (CHUIMI), Canarian Health Service, Las Palmas, Spain; Clinical Sciences Department, Universidad de Las Palmas de Gran Canaria, Canary Islands, Spain. LA - eng PT - Journal Article DEP - 20201120 PL - Netherlands TA - Sci Total Environ JT - The Science of the total environment JID - 0330500 RN - 0 (Environmental Pollutants) RN - 0 (Hydrocarbons, Chlorinated) RN - 0 (Pesticides) RN - DFC2HB4I0K (Polychlorinated Biphenyls) SB - IM MH - Aged MH - Biological Monitoring MH - *Environmental Pollutants MH - Female MH - Humans MH - *Hydrocarbons, Chlorinated MH - Persistent Organic Pollutants MH - *Pesticides MH - *Polychlorinated Biphenyls MH - Spain OTO - NOTNLM OT - Elderly people OT - Human biomonitoring OT - Organochlorine pesticides OT - Persistent organic pollutants OT - Polychlorinated biphenyls OT - Temporal trend COIS- Declaration of competing interest There are no actual or potential conflicts of interest to be declared for any author. EDAT- 2020/11/30 06:00 MHDA- 2021/01/13 06:00 CRDT- 2020/11/29 20:26 PHST- 2020/08/07 00:00 [received] PHST- 2020/11/02 00:00 [revised] PHST- 2020/11/08 00:00 [accepted] PHST- 2020/11/30 06:00 [pubmed] PHST- 2021/01/13 06:00 [medline] PHST- 2020/11/29 20:26 [entrez] AID - S0048-9697(20)37168-0 [pii] AID - 10.1016/j.scitotenv.2020.143637 [doi] PST - ppublish SO - Sci Total Environ. 2021 Mar 1;758:143637. doi: 10.1016/j.scitotenv.2020.143637. Epub 2020 Nov 20.