PMID- 33249032
OWN - NLM
STAT- MEDLINE
DCOM- 20210830
LR  - 20210830
IS  - 1090-2430 (Electronic)
IS  - 0014-4886 (Linking)
VI  - 336
DP  - 2021 Feb
TI  - Intra-arterial anti-oxidant power negatively correlates with white matter injury, 
      and oxidative stress positively correlates with disability in daily activities.
PG  - 113539
LID - S0014-4886(20)30370-8 [pii]
LID - 10.1016/j.expneurol.2020.113539 [doi]
AB  - Oxidative stress influences many kinds of diseases. Our hypothesis is that 
      oxidative stress and antioxidant potentials correlate with cognitive function, 
      activities of daily life and white matter injury. (UMIN-CTR R000016770) 
      Thirty-two consecutive patients participated to this study after informed 
      consent. A routine biochemical analysis, modified-Rankin Scale (m-RS), revised 
      Hasegawa Dementia Scale (HDS-R), Mini-Mental State Examination (MMSE) and 
      fluid-attenuated-inversion-recovery imaging (FLAIR) were performed before 
      admission. Derivatives of reactive oxygen metabolites (d-ROMs) and biological 
      antioxidant potential (BAP) were measured photometrically using arterial blood. 
      Statistical analyses were done by analysis variance or logistic regression 
      analysis. Median age was 72 (IQR: 64.3 -- 75.8). The d-ROMS were 367 +/- 55.4, and 
      BAP was 1967 +/- 284. HDS-R and m-RS deteriorated with d-ROMs elevation (p < 0.05). 
      Uric acid and creatinine decreased with d-ROMs elevation (p < 0.05). Both 
      periventricular hyperintensity grade and deep and subcortical white matter 
      hyperintensity grade worsened with BAP reduction (p < 0.05). Oxidative stress 
      correlates negatively with cognitive function and activities of daily life. Low 
      antioxidative potentials correlate with aggravation of white matter injury. We 
      should control both oxidative stress and antioxidative potential to maintain 
      healthy lives.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Norihito Shimamura
AU  - Norihito Shimamura
AD  - Department of Neurosurgery, Hirosaki University Graduate School of Medicine, 
      Japan. Electronic address: shimab@hirosaki-u.ac.jp.
FAU - Katagai, Takeshi
AU  - Katagai T
AD  - Department of Neurosurgery, Hirosaki University Graduate School of Medicine, 
      Japan.
FAU - Fujiwara, Nozomi
AU  - Fujiwara N
AD  - Department of Neurosurgery, Hirosaki University Graduate School of Medicine, 
      Japan.
FAU - Ueno, Kouta
AU  - Ueno K
AD  - Department of Neurosurgery, Hirosaki University Graduate School of Medicine, 
      Japan.
FAU - Watanabe, Ryouta
AU  - Watanabe R
AD  - Department of Neurosurgery, Hirosaki University Graduate School of Medicine, 
      Japan.
FAU - Fumoto, Toshio
AU  - Fumoto T
AD  - Department of Neurosurgery, Hirosaki University Graduate School of Medicine, 
      Japan.
FAU - Naraoka, Masato
AU  - Naraoka M
AD  - Department of Neurosurgery, Hirosaki University Graduate School of Medicine, 
      Japan.
FAU - Ohkuma, Hiroki
AU  - Ohkuma H
AD  - Department of Neurosurgery, Hirosaki University Graduate School of Medicine, 
      Japan.
LA  - eng
PT  - Journal Article
DEP - 20201127
PL  - United States
TA  - Exp Neurol
JT  - Experimental neurology
JID - 0370712
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Reactive Oxygen Species)
RN  - 268B43MJ25 (Uric Acid)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - *Activities of Daily Living
MH  - Aged
MH  - Antioxidants/*metabolism
MH  - Biomarkers
MH  - Cognition
MH  - Creatinine/blood
MH  - *Disability Evaluation
MH  - Female
MH  - Humans
MH  - Male
MH  - Mental Status and Dementia Tests
MH  - Middle Aged
MH  - *Oxidative Stress
MH  - Reactive Oxygen Species/analysis/metabolism
MH  - Uric Acid/blood
MH  - White Matter/*diagnostic imaging
OTO - NOTNLM
OT  - Activities of daily life
OT  - Antioxidative potential
OT  - Cognitive function
OT  - Oxidative stress
OT  - White matter lesion
EDAT- 2020/11/30 06:00
MHDA- 2021/08/31 06:00
CRDT- 2020/11/29 20:28
PHST- 2020/09/10 00:00 [received]
PHST- 2020/11/09 00:00 [revised]
PHST- 2020/11/22 00:00 [accepted]
PHST- 2020/11/30 06:00 [pubmed]
PHST- 2021/08/31 06:00 [medline]
PHST- 2020/11/29 20:28 [entrez]
AID - S0014-4886(20)30370-8 [pii]
AID - 10.1016/j.expneurol.2020.113539 [doi]
PST - ppublish
SO  - Exp Neurol. 2021 Feb;336:113539. doi: 10.1016/j.expneurol.2020.113539. Epub 2020 
      Nov 27.