PMID- 33249336
OWN - NLM
STAT- MEDLINE
DCOM- 20211103
LR  - 20230302
IS  - 1873-281X (Electronic)
IS  - 1472-9792 (Linking)
VI  - 126
DP  - 2021 Jan
TI  - Human leukocyte antigen associations with protection against tuberculosis 
      infection and disease in human immunodeficiency virus-1 infected individuals, 
      despite household tuberculosis exposure and immune suppression.
PG  - 102023
LID - S1472-9792(20)30190-6 [pii]
LID - 10.1016/j.tube.2020.102023 [doi]
AB  - BACKGROUND: To determine the association of human leukocyte antigen (HLA) alleles 
      as correlates of risk for and protection against tuberculin skin test (TST) 
      positivity and active TB disease amongst HIV-infected adults. METHODS: Genomic 
      DNA was extracted from 754 HIV-infected adults whole-blood. HLA-A, -B, -C and 
      -DRB1 loci were genotyped by next generation sequencing methods. HLA alleles were 
      analysed by the presence/absence of TST immune conversion and active TB disease 
      and further stratified by exposure to a household TB contact, CD4(+) T-cell count 
      and, for active TB disease, TST-positivity. RESULTS: HLA-A*29:11 and - B*45:01/07 
      were associated with TST-positivity, while HLA-A*24:02, -A*29:02 and -B*15:16 
      with TST-negativity. In participants with a household TB contact, HLA-A*66:01, 
      -A*68:02 and -B*49:01 were associated with TST-negativity. For TB disease, 
      HLA-B*41:01, -C*06:02, -DRB1*04:01 and -DRB1*15:01 were associated with 
      susceptibility, while HLA-B*07:02 and -DRB1*11:01 were protective, even for 
      CD4(+) T-cell count <350 cells/mm(3). For initial TST-positivity and subsequent 
      TB disease, HLA-A*01:01 and -DRB1*11:01 conveyed protection including for those 
      with CD4(+) T-cell count <350 cells/mm(3). CONCLUSION: Several HLA alleles are 
      noted as correlates of TB infection, risk and natural protection in HIV-infected 
      individuals. HLA associations may enable risk stratification of those with HIV 
      infection. Protective alleles may assist in future TB vaccine development.
CI  - Copyright (c) 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Seedat, Faheem
AU  - Seedat F
AD  - Department of Internal Medicine, Klerksdorp Tshepong Hospital Complex, Benji 
      Oliphant Road, North West Province Department of Health, University of the 
      Witwatersrand, South Africa. Electronic address: faheem@global.co.za.
FAU - James, Ian
AU  - James I
AD  - Institute for Immunology and Infectious Diseases, 90 South Street, Murdoch 
      University, Western Australia, Australia.
FAU - Loubser, Shayne
AU  - Loubser S
AD  - Centre for HIV and STIs, National Institute for Communicable Diseases, National 
      Health Laboratory Services, 1 Modderfontein Road and Faculty of Health Sciences, 
      University of the Witwatersrand, 1 Jan Smuts Avenue, Johannesburg, South Africa.
FAU - Waja, Ziyaad
AU  - Waja Z
AD  - Perinatal HIV Research Unit (PHRU), MRC Soweto Matlosana Collaborating Centre for 
      HIV/AIDS and TB, Chris Hani Road, Chris Hani Baragwanath Academic Hospital, 
      University of the Witwatersrand, South Africa.
FAU - Mallal, Simon A
AU  - Mallal SA
AD  - Department of Pathology, Microbiology and Immunology, 2201, West End Avenue, 
      Vanderbilt University, Nashville, TN, USA.
FAU - Hoffmann, Christopher
AU  - Hoffmann C
AD  - Johns Hopkins University Centre for TB Research, Charles Street, John Hopkins 
      University, Baltimore, MD, USA.
FAU - Tiemessen, Caroline T
AU  - Tiemessen CT
AD  - Centre for HIV and STIs, National Institute for Communicable Diseases, National 
      Health Laboratory Services, 1 Modderfontein Road and Faculty of Health Sciences, 
      University of the Witwatersrand, 1 Jan Smuts Avenue, Johannesburg, South Africa.
FAU - Chaisson, Richard E
AU  - Chaisson RE
AD  - Johns Hopkins University Centre for TB Research, Charles Street, John Hopkins 
      University, Baltimore, MD, USA.
FAU - Martinson, Neil A
AU  - Martinson NA
AD  - Perinatal HIV Research Unit (PHRU), MRC Soweto Matlosana Collaborating Centre for 
      HIV/AIDS and TB, Chris Hani Road, Chris Hani Baragwanath Academic Hospital, 
      University of the Witwatersrand, South Africa.
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20201119
PL  - Scotland
TA  - Tuberculosis (Edinb)
JT  - Tuberculosis (Edinburgh, Scotland)
JID - 100971555
RN  - 0 (DNA, Viral)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - CD4 Lymphocyte Count
MH  - Comorbidity
MH  - DNA, Viral/analysis
MH  - *Family Characteristics
MH  - Female
MH  - Follow-Up Studies
MH  - HIV Infections/epidemiology/*immunology/*virology
MH  - HIV-1/*genetics
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - Incidence
MH  - Latent Tuberculosis/epidemiology/*immunology/microbiology
MH  - Male
MH  - Mycobacterium tuberculosis/*immunology
MH  - Prospective Studies
MH  - South Africa/epidemiology
MH  - Tuberculin Test
OTO - NOTNLM
OT  - Active TB disease
OT  - Correlates of protection
OT  - HLA alleles
OT  - Latent TB infection
OT  - TST immune conversion
EDAT- 2020/11/30 06:00
MHDA- 2021/11/04 06:00
CRDT- 2020/11/29 20:31
PHST- 2020/09/03 00:00 [received]
PHST- 2020/11/04 00:00 [revised]
PHST- 2020/11/15 00:00 [accepted]
PHST- 2020/11/30 06:00 [pubmed]
PHST- 2021/11/04 06:00 [medline]
PHST- 2020/11/29 20:31 [entrez]
AID - S1472-9792(20)30190-6 [pii]
AID - 10.1016/j.tube.2020.102023 [doi]
PST - ppublish
SO  - Tuberculosis (Edinb). 2021 Jan;126:102023. doi: 10.1016/j.tube.2020.102023. Epub 
      2020 Nov 19.