PMID- 33249527
OWN - NLM
STAT- MEDLINE
DCOM- 20220615
LR  - 20220615
IS  - 0171-2004 (Print)
IS  - 0171-2004 (Linking)
VI  - 273
DP  - 2022
TI  - Structure and Function of the Blood-Brain Barrier (BBB).
PG  - 3-31
LID - 10.1007/164_2020_404 [doi]
AB  - The blood-brain barrier (BBB) protects the vertebrate central nervous system from 
      harmful blood-borne, endogenous and exogenous substances to ensure proper 
      neuronal function. The BBB describes a function that is established by 
      endothelial cells of CNS vessels in conjunction with pericytes, astrocytes, 
      neurons and microglia, together forming the neurovascular unit (NVU). Endothelial 
      barrier function is crucially induced and maintained by the Wnt/beta-catenin pathway 
      and requires intact NVU for proper functionality. The BBB and the NVU are 
      characterized by a specialized assortment of molecular specializations, providing 
      the basis for tightening, transport and immune response functionality.The present 
      chapter introduces state-of-the-art knowledge of BBB structure and function and 
      highlights current research topics, aiming to understanding in more depth the 
      cellular and molecular interactions at the NVU, determining functionality of the 
      BBB in health and disease, and providing novel potential targets for therapeutic 
      BBB modulation. Moreover, we highlight recent advances in understanding BBB and 
      NVU heterogeneity within the CNS as well as their contribution to CNS physiology, 
      such as neurovascular coupling, and pathophysiology, is discussed. Finally, we 
      give an outlook onto new avenues of BBB research.
CI  - (c) 2020. Springer Nature Switzerland AG.
FAU - Benz, Fabienne
AU  - Benz F
AD  - Institute of Neurology (Edinger Institute), University Hospital, Goethe 
      University Frankfurt, Frankfurt am Main, Germany.
FAU - Liebner, Stefan
AU  - Liebner S
AD  - Institute of Neurology (Edinger Institute), University Hospital, Goethe 
      University Frankfurt, Frankfurt am Main, Germany. Stefan.Liebner@kgu.de.
AD  - Excellence Cluster Cardio Pulmonary System (CPI), Partner Site Frankfurt, 
      Frankfurt, Germany. Stefan.Liebner@kgu.de.
AD  - German Center for Cardiovascular Research (DZHK), Partner Site Frankfurt/Mainz, 
      Frankfurt, Germany. Stefan.Liebner@kgu.de.
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Handb Exp Pharmacol
JT  - Handbook of experimental pharmacology
JID - 7902231
SB  - IM
MH  - Astrocytes
MH  - Biological Transport
MH  - *Blood-Brain Barrier/metabolism
MH  - *Endothelial Cells/metabolism
MH  - Humans
MH  - Pericytes/metabolism
OTO - NOTNLM
OT  - BBB development
OT  - Blood-brain barrier
OT  - Circumventricular organs
OT  - Neurovascular unit
OT  - Vascular heterogeneity
OT  - Wnt signalling
EDAT- 2020/11/30 06:00
MHDA- 2022/06/16 06:00
CRDT- 2020/11/29 20:35
PHST- 2020/11/30 06:00 [pubmed]
PHST- 2022/06/16 06:00 [medline]
PHST- 2020/11/29 20:35 [entrez]
AID - 10.1007/164_2020_404 [doi]
PST - ppublish
SO  - Handb Exp Pharmacol. 2022;273:3-31. doi: 10.1007/164_2020_404.