PMID- 33250080
OWN - NLM
STAT- MEDLINE
DCOM- 20210317
LR  - 20210317
IS  - 1471-4981 (Electronic)
IS  - 1471-4906 (Linking)
VI  - 41
IP  - 12
DP  - 2020 Dec
TI  - Decoding the Heterogeneity of Human Dendritic Cell Subsets.
PG  - 1062-1071
LID - S1471-4906(20)30231-3 [pii]
LID - 10.1016/j.it.2020.10.002 [doi]
AB  - Dendritic cells (DCs) have been classified into distinct subsets based on 
      phenotype and ontogeny. In the past few years, high throughput single-cell 
      approaches have revealed further heterogeneity of human DCs, in particular at the 
      transcriptomic level. Herein examined, are recent studies describing new human DC 
      populations based on single-cell RNA-seq analysis, and a unified view of these 
      emerging DC populations is presented. Also assessed are the features that define 
      bona fide DC lineages, as opposed to cell states of the same lineage. Finally, 
      where these newly described DC populations fit in the ontogeny-based 
      classification of human DCs is examined.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Villar, Javiera
AU  - Villar J
AD  - Institut Curie, PSL Research University, INSERM, U932, 26 rue d'Ulm, Paris, 
      France.
FAU - Segura, Elodie
AU  - Segura E
AD  - Institut Curie, PSL Research University, INSERM, U932, 26 rue d'Ulm, Paris, 
      France. Electronic address: elodie.segura@curie.fr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20201023
PL  - England
TA  - Trends Immunol
JT  - Trends in immunology
JID - 100966032
SB  - IM
MH  - *Dendritic Cells/classification/cytology
MH  - Humans
MH  - Phenotype
MH  - *Transcriptome
EDAT- 2020/12/01 06:00
MHDA- 2021/03/18 06:00
CRDT- 2020/11/30 05:26
PHST- 2020/06/10 00:00 [received]
PHST- 2020/09/30 00:00 [revised]
PHST- 2020/10/07 00:00 [accepted]
PHST- 2020/11/30 05:26 [entrez]
PHST- 2020/12/01 06:00 [pubmed]
PHST- 2021/03/18 06:00 [medline]
AID - S1471-4906(20)30231-3 [pii]
AID - 10.1016/j.it.2020.10.002 [doi]
PST - ppublish
SO  - Trends Immunol. 2020 Dec;41(12):1062-1071. doi: 10.1016/j.it.2020.10.002. Epub 
      2020 Oct 23.