PMID- 33250412
OWN - NLM
STAT- MEDLINE
DCOM- 20211126
LR  - 20211126
IS  - 1472-6491 (Electronic)
IS  - 1472-6483 (Linking)
VI  - 42
IP  - 2
DP  - 2021 Feb
TI  - The relationship between a novel evaluation parameter of premature luteinization 
      and IVF outcomes.
PG  - 323-331
LID - S1472-6483(20)30574-5 [pii]
LID - 10.1016/j.rbmo.2020.10.009 [doi]
AB  - RESEARCH QUESTION: Can premature luteinization of granulosa cells (PLGC) act as a 
      novel parameter of premature luteinization and affect IVF outcomes? STUDY DESIGN: 
      In this retrospective cohort study, infertile patients undergoing fresh IVF 
      cycles between January 2006 and December 2016 at the Reproductive Medicine Center 
      in Tongji Hospital were included. A total of 42,468 cycles were conducted. 
      Propensity score matching was carried out to match the baseline characteristics, 
      and participants were assigned to the PLGC group and control group. The main 
      outcomes were pregnancy rate and live birth rate. RESULTS: Patient 
      characteristics and clinical outcomes were compared before and after matching. In 
      general, the fate of oocytes in the PLGC group was much worse than those in the 
      control group after matching, including metaphase II rate, two-pronuclei rate, 
      available embryo rate, blastocyst formation rate, high-quality blastocyst rate, 
      pregnancy rate, implantation rate and live birth rate. Among those potential risk 
      factors, gonadotrophin duration, oestradiol and progesterone on HCG day were 
      positively associated with the occurrence of PLGC in the multivariate logistic 
      regression model, with gonadotrophin dosage negatively related. Moreover, 
      cumulus-oocyte complexes with PLGC showed a high correlation with elevated 
      progesterone levels over 1.5 ng/ml. CONCLUSIONS: Our findings demonstrated the 
      adverse effect of PLGC on oocyte competency. In evaluating cumulus-oocyte 
      complexes, PLGC provide an available novel parameter for premature luteinization 
      judgement in clinical and individualized precise treatment. Close monitoring of 
      progesterone level as well as critical analysis of progesterone elevation can 
      reduce the occurrence of premature luteinization.
CI  - Copyright (c) 2020 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All 
      rights reserved.
FAU - Wang, Meng
AU  - Wang M
AD  - Reproductive Medicine Centre, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan 430000, 
      China.
FAU - Xi, Qingsong
AU  - Xi Q
AD  - Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Yang, Qiyu
AU  - Yang Q
AD  - Reproductive Medicine Centre, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan 430000, 
      China.
FAU - Li, Zhou
AU  - Li Z
AD  - Reproductive Medicine Centre, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan 430000, 
      China.
FAU - Yang, Liu
AU  - Yang L
AD  - Reproductive Medicine Centre, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan 430000, 
      China.
FAU - Zhu, Lixia
AU  - Zhu L
AD  - Reproductive Medicine Centre, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan 430000, 
      China. Electronic address: zhulixia027@foxmail.com.
FAU - Jin, Lei
AU  - Jin L
AD  - Reproductive Medicine Centre, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan 430000, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20201022
PL  - Netherlands
TA  - Reprod Biomed Online
JT  - Reproductive biomedicine online
JID - 101122473
RN  - 4G7DS2Q64Y (Progesterone)
SB  - IM
MH  - Adult
MH  - Female
MH  - Fertilization in Vitro/*statistics & numerical data
MH  - Humans
MH  - *Luteinization
MH  - Oocytes/*growth & development
MH  - Pregnancy
MH  - Progesterone/*blood
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Granulosa cells
OT  - Oocyte competence
OT  - Premature LH surge
OT  - Premature luteinisation
OT  - Progesterone evaluation
EDAT- 2020/12/01 06:00
MHDA- 2021/11/27 06:00
CRDT- 2020/11/30 05:33
PHST- 2020/07/15 00:00 [received]
PHST- 2020/09/23 00:00 [revised]
PHST- 2020/10/15 00:00 [accepted]
PHST- 2020/12/01 06:00 [pubmed]
PHST- 2021/11/27 06:00 [medline]
PHST- 2020/11/30 05:33 [entrez]
AID - S1472-6483(20)30574-5 [pii]
AID - 10.1016/j.rbmo.2020.10.009 [doi]
PST - ppublish
SO  - Reprod Biomed Online. 2021 Feb;42(2):323-331. doi: 10.1016/j.rbmo.2020.10.009. 
      Epub 2020 Oct 22.