PMID- 33250836
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201201
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 11
DP  - 2020
TI  - Preferentially Disrupted Core Hubs Within the Default-Mode Network in Patients 
      With End-Stage Renal Disease: A Resting-State Functional Magnetic Resonance 
      Imaging Study.
PG  - 1032
LID - 10.3389/fneur.2020.01032 [doi]
LID - 1032
AB  - Neuroimaging evidence implies that cognitive impairment in patients with 
      end-stage renal disease (ESRD) is related to the disruption of the default-mode 
      network (DMN). The DMN can be divided into three functionally independent 
      subsystems, which include the cortical hub subsystem [consisting of the posterior 
      cingulate cortex (PCC) and the anterior medial prefrontal cortex (aMPFC)], the 
      dorsal medial prefrontal cortex (dMPFC) subsystem, and the medial temporal lobe 
      (MTL) subsystem. However, it is unknown how the functional connectivity (FC) in 
      DMN subsystems is differentially impaired in ESRD. This prospective study was 
      carried out at the Affiliated Hospital of Qingdao University, China, between 
      August 2018 and July 2020. Thirty-two ESRD patients and forty-five healthy 
      controls (HCs) were recruited for this study and received resting-state 
      functional magnetic resonance imaging (rs-fMRI) scanning, and FCs on predefined 
      regions of interest (ROIs) were individually calculated in three DMN subsystems 
      using both ROI- and seed-based FC analyses to examine FC alterations within and 
      between DMN subsystems. The two-sample t-test was used for the comparisons 
      between groups. We also tested the associations between FC changes and clinical 
      information using Pearson's correlation analysis. The results demonstrated that 
      ESRD patients, compared with HCs, exhibit reduced FC specifically within the 
      cortical hubs and between the DMN hubs and two subsystems (the dMPFC and MTL 
      subsystems). Moreover, the FC values between the aMPFC and PCC were positively 
      correlated with creatinine and urea levels in the ESRD patients. Our results 
      suggest that the cortical hubs (PCC and aMPFC) are preferentially disrupted and 
      that other subsystems may be progressively damaged to a certain degree as the 
      disease develops.
CI  - Copyright (c) 2020 Ma, Tian, Ma, Su, Fan, Li and Ren.
FAU - Ma, Chi
AU  - Ma C
AD  - Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, 
      China.
FAU - Tian, Fen
AU  - Tian F
AD  - Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, 
      China.
FAU - Ma, Min-Ge
AU  - Ma MG
AD  - Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, 
      China.
FAU - Su, Hua-Wei
AU  - Su HW
AD  - Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, 
      China.
FAU - Fan, Jian-Cong
AU  - Fan JC
AD  - College of Computer Science and Engineering, Shandong University of Science and 
      Technology, Qingdao, China.
FAU - Li, Zhan-Hui
AU  - Li ZH
AD  - College of Computer Science and Engineering, Shandong University of Science and 
      Technology, Qingdao, China.
FAU - Ren, Yan-de
AU  - Ren YD
AD  - Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20201105
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC7674924
OTO - NOTNLM
OT  - cognitive impairment
OT  - default-mode network
OT  - end-stage renal disease
OT  - functional connectivity
OT  - resting-state functional magnetic resonance imaging
EDAT- 2020/12/01 06:00
MHDA- 2020/12/01 06:01
PMCR- 2020/11/05
CRDT- 2020/11/30 05:53
PHST- 2020/04/30 00:00 [received]
PHST- 2020/08/07 00:00 [accepted]
PHST- 2020/11/30 05:53 [entrez]
PHST- 2020/12/01 06:00 [pubmed]
PHST- 2020/12/01 06:01 [medline]
PHST- 2020/11/05 00:00 [pmc-release]
AID - 10.3389/fneur.2020.01032 [doi]
PST - epublish
SO  - Front Neurol. 2020 Nov 5;11:1032. doi: 10.3389/fneur.2020.01032. eCollection 
      2020.