PMID- 33251195
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201201
IS  - 2296-4185 (Print)
IS  - 2296-4185 (Electronic)
IS  - 2296-4185 (Linking)
VI  - 8
DP  - 2020
TI  - Immunomodulation of MSCs and MSC-Derived Extracellular Vesicles in 
      Osteoarthritis.
PG  - 575057
LID - 10.3389/fbioe.2020.575057 [doi]
LID - 575057
AB  - Osteoarthritis (OA) has become recognized as a low-grade inflammatory state. 
      Inflammatory infiltration of the synovium by macrophages, T cells, B cells, and 
      other immune cells is often observed in OA patients and plays a key role in the 
      pathogenesis of OA. Hence, orchestrating the local inflammatory microenvironment 
      and tissue regeneration microenvironment is important for the treatment of OA. 
      Mesenchymal stem cells (MSCs) offer the potential for cartilage regeneration 
      owing to their effective immunomodulatory properties and anti-inflammatory 
      abilities. The paracrine effect, mediated by MSC-derived extracellular vehicles 
      (EVs), has recently been suggested as a mechanism for their therapeutic 
      properties. In this review, we summarize the interactions between MSCs or 
      MSC-derived EVs and OA-related immune cells and discuss their therapeutic effects 
      in OA. Additionally, we discuss the potential of MSC-derived EVs as a novel 
      cell-free therapy approach for the clinical treatment of OA.
CI  - Copyright (c) 2020 Zhao, Zhao, Sun, Xing, Wang and Yang.
FAU - Zhao, Xige
AU  - Zhao X
AD  - Stomatological Hospital of Tianjin Medical University, Tianjin, China.
FAU - Zhao, Yanhong
AU  - Zhao Y
AD  - Stomatological Hospital of Tianjin Medical University, Tianjin, China.
FAU - Sun, Xun
AU  - Sun X
AD  - Department of Spine Surgery, Tianjin Hospital, Tianjin University, Tianjin, 
      China.
FAU - Xing, Yi
AU  - Xing Y
AD  - Stomatological Hospital of Tianjin Medical University, Tianjin, China.
FAU - Wang, Xing
AU  - Wang X
AD  - Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, 
      Chinese Academy of Sciences, Beijing, China.
AD  - University of Chinese Academy of Sciences, Beijing, China.
FAU - Yang, Qiang
AU  - Yang Q
AD  - Department of Spine Surgery, Tianjin Hospital, Tianjin University, Tianjin, 
      China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20201029
PL  - Switzerland
TA  - Front Bioeng Biotechnol
JT  - Frontiers in bioengineering and biotechnology
JID - 101632513
PMC - PMC7673418
OTO - NOTNLM
OT  - MSCs
OT  - exosomes
OT  - immunomodulatory
OT  - macrophage
OT  - osteoarthritis
EDAT- 2020/12/01 06:00
MHDA- 2020/12/01 06:01
PMCR- 2020/01/01
CRDT- 2020/11/30 05:54
PHST- 2020/06/22 00:00 [received]
PHST- 2020/09/21 00:00 [accepted]
PHST- 2020/11/30 05:54 [entrez]
PHST- 2020/12/01 06:00 [pubmed]
PHST- 2020/12/01 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fbioe.2020.575057 [doi]
PST - epublish
SO  - Front Bioeng Biotechnol. 2020 Oct 29;8:575057. doi: 10.3389/fbioe.2020.575057. 
      eCollection 2020.