PMID- 33251334
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201201
IS  - 2372-7705 (Print)
IS  - 2372-7705 (Electronic)
IS  - 2372-7705 (Linking)
VI  - 19
DP  - 2020 Dec 16
TI  - Regulation of Glycolysis by Non-coding RNAs in Cancer: Switching on the Warburg 
      Effect.
PG  - 218-239
LID - 10.1016/j.omto.2020.10.003 [doi]
AB  - The "Warburg effect" describes the reprogramming of glucose metabolism away from 
      oxidative phosphorylation toward aerobic glycolysis, and it is one of the 
      hallmarks of cancer cells. Several factors can be involved in this process, but 
      in this review, the roles of non-coding RNAs (ncRNAs) are highlighted in several 
      types of human cancer. ncRNAs, including microRNAs, long non-coding RNAs, and 
      circular RNAs, can all affect metabolic enzymes and transcription factors to 
      promote glycolysis and modulate glucose metabolism to enhance the progression of 
      tumors. In particular, the 5'-AMP-activated protein kinase (AMPK) and the 
      phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) 
      pathways are associated with alterations in ncRNAs. A better understanding of the 
      roles of ncRNAs in the Warburg effect could ultimately lead to new therapeutic 
      approaches for suppressing cancer.
CI  - (c) 2020 The Author(s).
FAU - Mirzaei, Hamed
AU  - Mirzaei H
AD  - Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute 
      for Basic Sciences, Kashan University of Medical Sciences, Kashan, I.R. Iran.
FAU - Hamblin, Michael R
AU  - Hamblin MR
AD  - Laser Research Centre, Faculty of Health Science, University of Johannesburg, 
      Doornfontein, Johannesburg 2028, South Africa.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20201010
PL  - United States
TA  - Mol Ther Oncolytics
JT  - Molecular therapy oncolytics
JID - 101666776
PMC - PMC7666327
OTO - NOTNLM
OT  - Warburg effect
OT  - cancer
OT  - glycolysis
OT  - non-coding RNAs
EDAT- 2020/12/01 06:00
MHDA- 2020/12/01 06:01
PMCR- 2020/10/10
CRDT- 2020/11/30 05:55
PHST- 2020/11/30 05:55 [entrez]
PHST- 2020/12/01 06:00 [pubmed]
PHST- 2020/12/01 06:01 [medline]
PHST- 2020/10/10 00:00 [pmc-release]
AID - S2372-7705(20)30154-6 [pii]
AID - 10.1016/j.omto.2020.10.003 [doi]
PST - epublish
SO  - Mol Ther Oncolytics. 2020 Oct 10;19:218-239. doi: 10.1016/j.omto.2020.10.003. 
      eCollection 2020 Dec 16.