PMID- 33251635
OWN - NLM
STAT- MEDLINE
DCOM- 20210917
LR  - 20210917
IS  - 1521-4095 (Electronic)
IS  - 0935-9648 (Linking)
VI  - 33
IP  - 2
DP  - 2021 Jan
TI  - Tailored Mesoporous Inorganic Biomaterials: Assembly, Functionalization, and Drug 
      Delivery Engineering.
PG  - e2005215
LID - 10.1002/adma.202005215 [doi]
AB  - Infectious or immune diseases have caused serious threat to human health due to 
      their complexity and specificity, and emerging drug delivery systems (DDSs) have 
      evolved into the most promising therapeutic strategy for drug-targeted therapy. 
      Various mesoporous biomaterials are exploited and applied as efficient 
      nanocarriers to loading drugs by virtue of their large surface area, high 
      porosity, and prominent biocompatibility. Nanosized mesoporous nanocarriers show 
      great potential in biomedical research, and it has become the research hotspot in 
      the interdisciplinary field. Herein, recent progress and assembly mechanisms on 
      mesoporous inorganic biomaterials (e.g., silica, carbon, metal oxide) are 
      summarized systematically, and typical functionalization methods (i.e., 
      hybridization, polymerization, and doping) for nanocarriers are also discussed in 
      depth. Particularly, structure-activity relationship and the effect of 
      physicochemical parameters of mesoporous biomaterials, including morphologies 
      (e.g., hollow, core-shell), pore textures (e.g., pore size, pore volume), and 
      surface features (e.g., roughness and hydrophilic/hydrophobic) in DDS application 
      are overviewed and elucidated in detail. As one of the important development 
      directions, advanced stimuli-responsive DDSs (e.g., pH, temperature, redox, 
      ultrasound, light, magnetic field) are highlighted. Finally, the prospect of 
      mesoporous biomaterials in disease therapeutics is stated, and it will open a new 
      spring for the development of mesoporous nanocarriers.
CI  - (c) 2020 Wiley-VCH GmbH.
FAU - Zou, Yidong
AU  - Zou Y
AUID- ORCID: 0000-0002-3549-8430
AD  - Institute of Translational Medicine, Shanghai University, Shanghai, 200444, 
      China.
FAU - Huang, Biaotong
AU  - Huang B
AD  - Institute of Translational Medicine, Shanghai University, Shanghai, 200444, 
      China.
FAU - Cao, Liehu
AU  - Cao L
AD  - Department of Orthopedics, Shanghai Changhai Hospital, Second Military Medical 
      University, Shanghai, 200433, China.
AD  - Department of Orthopedics Trauma, Shanghai Luodian Hospital, Baoshan District, 
      Shanghai, 201908, China.
FAU - Deng, Yonghui
AU  - Deng Y
AUID- ORCID: 0000-0002-0657-9397
AD  - Department of Chemistry, State Key Laboratory of Molecular Engineering of 
      Polymers, Department of Gastroenterology and Hepatology, Zhongshan Hospital, 
      Fudan University, Shanghai, 200433, China.
AD  - State Key Lab of Transducer Technology, Shanghai Institute of Microsystem and 
      Information Technology, Chinese Academy of Sciences, Shanghai, 200050, China.
FAU - Su, Jiacan
AU  - Su J
AD  - Institute of Translational Medicine, Shanghai University, Shanghai, 200444, 
      China.
AD  - Department of Orthopedics, Shanghai Changhai Hospital, Second Military Medical 
      University, Shanghai, 200433, China.
LA  - eng
GR  - 91749204/NSF of China/
GR  - 81771491/NSF of China/
GR  - 21673048/NSF of China/
GR  - 21875044/NSF of China/
GR  - 2018YFA0209401/National Key Research and Development Program of China/
GR  - 20JC1415300/Science and Technology Commission of Shanghai Municipality/
GR  - 19XD1420300/Program of Shanghai Academic Research Leader/
GR  - SKT1904/state key laboratory of Transducer Technology of China/
GR  - Youth Top-notch Talent Support Program of China/
PT  - Journal Article
PT  - Review
DEP - 20201130
PL  - Germany
TA  - Adv Mater
JT  - Advanced materials (Deerfield Beach, Fla.)
JID - 9885358
RN  - 0 (Biocompatible Materials)
RN  - 0 (Drug Carriers)
RN  - 0 (Inorganic Chemicals)
SB  - IM
MH  - Biocompatible Materials/*chemistry
MH  - Drug Carriers/*chemistry
MH  - *Engineering
MH  - Inorganic Chemicals/*chemistry
MH  - Porosity
OTO - NOTNLM
OT  - disease therapy
OT  - drug delivery
OT  - mesoporous nanocarriers
OT  - stimuli-responsive system
EDAT- 2020/12/01 06:00
MHDA- 2021/09/18 06:00
CRDT- 2020/11/30 05:57
PHST- 2020/07/31 00:00 [received]
PHST- 2020/08/18 00:00 [revised]
PHST- 2020/12/01 06:00 [pubmed]
PHST- 2021/09/18 06:00 [medline]
PHST- 2020/11/30 05:57 [entrez]
AID - 10.1002/adma.202005215 [doi]
PST - ppublish
SO  - Adv Mater. 2021 Jan;33(2):e2005215. doi: 10.1002/adma.202005215. Epub 2020 Nov 
      30.